Journal Club

Crystals of a computationally designed protein
Crystals of a computationally designed protein Image by Lindsey Doyle

2018-2019 FHCRC Structural Biology and Molecular Biophysics Journal Club

Fred Hutch's Structural Biology and Molecular Biophysics Journal Club is held in Weintraub Building, room A3M-015.

Date Presenter Topic
October 11 Barry Stoddard "Characterization and engineering of a plastic-degrading aromatic polyesteraseAustin et al. (2018) PNAS 115 (19): E4350-E4357.    PUBMED  PUBMEDCENTRAL
October 25 Roland Strong "Specific Amyloid Binding of Polybasic Peptides In Vivo Is Retained by β-Sheet Conformers but Lost in the Disrupted Coil and All D-Amino Acid Variants" Wall, JS et al. (2017)  Mol. Imagining Biol. (19)5: 714-722.  PUBMED   PUBMEDCENTRAL   DOI
November 8 Marie Pancera "CryoEM structure of P. falciparum circumsporozoite protein with a vaccine-elicited antibody is stabilized by somatically mutated inter-FAB contacts" Oyen et al. (2018) Sci. Adv. 4 (10): eaau852. PUBMED    PUBMEDCENTRAL   DOI
November 15 Julian Simon "TMC1 forms the pore of mechanosensory transduction channels in vertebrate inner ear hair cells" Pan et al. (2018) Neuron 99: 736 - 753.   PUBMED      DOI
November 22 — Happy Thanksgiving!
November 29 Phil Bradley "Protein structure determination using metagenome sequence data" Ovchinnikov et al.  (2017) Science 355: 294 - 298.  PUBMED   DOI
December 13 Abigail Lambert (Stoddard Lab) "The cryo-electron microscopy structure of huntingtin" Guo et al. Nature 555: 117 - 120.   DOI     PUBMED
December 13/20/27 — No Meetings...Happy Christmas, Hannakah, Kwanzaa, Festivus, etc.
January 3 — Still No Meeting...Happy New Year
January 10 Mesfin Gewe/ Colin Correnti (Olson Lab and FHCRC Molecular Therapeutics/Protein Core) "BiTEs and SMITEs: Improving Bispecific Therapies Through T Cell Costimulation”  (NO READING)
January 24 Peter Rupert (Strong Lab) "Structural insight into the photochemistry of split green fluorescent proteins: a unique role for a His-tag" (2018) J. Amer. Chem. Soc.140: 375 - 381.  DOI  PUBMED
February 7 No meeting  
February 21 Connor Weidle (Pancera/Stamatatos Lab)
Batra et al. (2018) Cell (epub 18-Dec-2018) "Protein Interaction Mapping Identifies RBBP6 as a Negative Regulator of Ebola Virus Replication"
March 7 Lindsey Doyle (Stoddard Lab) An overview of Vault Ribonucleoprotein. "Solution Structures of Engineered Vault Particles" Ding et al (2018) Structure 26: 619-626.  DOI  
March 21 Nick Hurlburt (Stamatatos/Pancera Lab) "Crystal structure of plant vacuolar iron transporter VIT1" Kato et al. (2019) Nature Plants 5: 308-315. DOI  PUBMED
April 3  (NOTE: WEDNESDAY, NOT THURSDAY) Barry Stoddard (Stoddard Lab) Grinberg et al. (2018) “Novel ATP-con-driven allosteric regulation of ribonucleotide reductase via the radical-generating subunit” eLIFE DOI: 10.7554/eLife.31529  PubMed 29388911
April 18 Rachel Werther (Stoddard Lab) Liu, Qingbo et al. “Improvement of antibody functionality by structure-guided paratope engraftment” Nature communications vol. 10,1 721. 13 Feb. 2019  DOI   PMCID
May 2 OPEN  
May 16 OPEN  
May 30 Suruchi Singh (Pancera/Stamatatos Lab) Coleman, Jonathan A. et al. "Serotonin transporter–ibogaine complexes illuminate mechanisms of inhibition and transport" Nature 569, 141–145 (2019). DOI
June 13 Shen Hao Hao Shen, et.al. “De novo design of self-assembling helical protein filaments”. (2018) Sci. Vol. 362 issue 6415, pp 705 - 709. DOI PMID