Saha Lab

Saha Lab

Saha Lab members in lab coats

Our Research

Cancers of the liver and intrapehatic bile ducts are the fastest growing cancers in the United States. In order to address this growing menace, we have developed a robust panel of liver cancer model systems that properly reflect both the genetic and epigenetic diversity of these human diseases. Our laboratory uses a combination of both functional genomic screens and small molecular inhibitors as chemical probes to identify previously unrecognized pathways and targets in these diseases with the hopes of translating our findings into new therapeutic avenues for patients. More fundamentally, our genetically engineered mouse models are used to elucidate pathogenic mechanisms driving liver cancer, including how these cancers effectively evade our immunosurveillance mechanisms as well as how epigenetic dysregulation contributes to biological outcomes and impact the response to targeted therapies currently being explored in the clinic.  
 

Dr. Supriya Saha describes his research and explains how philanthropic donations propel his work forward.