2018 | 2017 | 2016 | 2015 | 2014 | 2013 | 2012 | 2011 | 2010 | 2009 | 2008 | 2005 | 2003 | 2002


Preprint: A Highly Efficient and Faithful MDS Patient-Derived Xenotransplantation Model for Pre-Clinical Studies. Y. Song, A. Rongvaux, A. Taylor, T. Jiang, T. Tebaldi, K. Balasubramanian, A. Bagale, Y.K. Terzi, R. Gbyli, X. Wang, J. Zhao, N. Podoltsev, M. Xu, N. Neparidze, E. Wong, R. Torres, E.M. Bruscia, Y. Kluger, M.G. Manz, R.A. Flavell, S. Halene. Nature Communications. In press.

Innate immunity and tolerance toward mitochondria. A. Rongvaux. Mitochondrion. 2018 Jul;41:14-20.


The fate and lifespan of human monocyte subsets in steady state and systemic inflammation. A.A. Patel, Y. Zhang, J.N. Fullerton, L. Boelen, A. Rongvaux, A.A. Maini, V. Bigley, R.A. Flavell, D.W. Gilroy, B. Asquith, D. Macallan, S. Yona. J Exp Med. 2017 Jul 3;214(7):1913-1923. 


Glioma-induced inhibition of caspase-3 in microglia promotes a tumor-supportive phenotype. X. Shen, M.A. Burguillos, A.M. Osman, J. Frijhoff, A. Carrillo-Jiménez, S. Kanatani, M. Augsten, D. Saidi, J. Rodhe, E. Kavanagh, A. Rongvaux, V. Rraklli, U. Nyman, J. Holmberg, A. Östman, R.A. Flavell, A. Barragan, J.L. Venero, K. Blomgren, B. Joseph. Nat Immunol. 2016 Nov;17(11):1282-1290.

Activity of Uncleaved Caspase-8 Controls Anti-bacterial Immune Defense and TLR-Induced Cytokine Production Independent of Cell Death. N.H. Philip, A. DeLaney, L.W. Peterson, M. Santos-Marrero, J.T. Grier, Y. Sun, M.A. Wynosky-Dolfi, E.E. Zwack, B. Hu, T.M. Olsen, A. Rongvaux, S.D. Pope, C.B. López, A. Oberst, D.P. Beiting, J. Henao-Mejia, I.E. Brodsky. PLoS Pathog. 2016 Oct 13;12(10):e1005910. doi: 10.1371/journal.ppat. 

Peripheral blood CD34(+) cells efficiently engraft human cytokine knock-in mice. Y. Saito, J.M. Ellegast, A. Rafiei, Y. Song, D. Kull, M. Heikenwalder, A. Rongvaux, S. Halene, R.A. Flavell, M.G. Manz. Blood. 2016 Oct 6;128(14):1829-1833.

Generation of Genetically Modified Mice Using the CRISPR-Cas9 Genome-Editing System. J. Henao-Mejia, A. Williams, A. Rongvaux, J. Stein, C. Hughes, R.A. Flavell. Cold Spring Harbor Protocols. 2016 Feb 1; doi: 10.1101/pdb.prot090704.

Intracellular nicotinamide adenine dinucleotide promotes TNF-induced necroptosis in a sirtuin-dependent manner. N. Preyat, M. Rossi, J. Kers, L. Chen, J. Bertin, P.J. Gough, A. Le Moine, A. Rongvaux, F. Van Gool, O. Leo. Cell Death and Differentiation. 2016 Jan;23(1):29-40.

Humanized hemato-lymphoid system mice. A.P. Theocharides, A. Rongvaux, K. Fritsch, R.A. Flavell, M.G. Manz. Haematologica. 2016. 101(1):5-19. 


Nlrp6 regulates intestinal antiviral innate immunityP. Wang, S. Zhu, L. Yang, S. Cui, W. Pan, R. Jackson, Y. Zheng, A. Rongvaux, Q. Sun, G. Yang, S. Gao, P. Lin, F. You, R. Flavell, E. Fikrig. Science. 2015 Nov 13;350(6262):826-30.

Executioner Caspase-3 and 7 Deficiency Reduces Myocyte Number in the Developing Mouse Heart. M. Cardona, J.A. López, A. Serafín, A. Rongvaux, J. Inserte, D. García-Dorado, R. Flavell, M. Llovera, X. Cañas, J. Vázquez, D. Sanchis. PLoS One. 2015 Jun 29;10(6):e0131411.

Improvement of human multilineage hematopoietic engraftment by cytokine knockin replacement in human-hemato-lymphoid system mice. A. Rongvaux, M.G. Manz, R.A. Flavell. In: L.Y. Poluektova, J.V. Garcia-Martinez, Y. Koyanagi, M.G. Manz, A.M. Tager, editors. Humanized mice for HIV research. 2015. Springer.

Broad CTL response is required to clear latent HIV-1 due to dominance of escape mutations. K. Deng, M. Pertea, A. Rongvaux, L. Wang, C.M. Durand, G. Ghiaur, J. Lai, H. Hao, C. Gurer, A.J. Murphy, D.M. Valenzuela, G.D. Yancopoulos, T. Strowig, P. Kumar, S.G. Deeks, J.D. Siliciano, S.L. Salzberg, R.A. Flavell, L. Shan, R.F. Siliciano. Nature. 2015. 517(7534):381-5.


Apoptotic caspases prevent the induction of type I interferons by mitochondrial DNA. A. Rongvaux, R. Jackson, C. Harman, T. Li, A.P. West, M.R. de Zoete, Y. Wu, B. Yordy, S.A. Lakhani, C.Y. Kuan, T. Taniguchi, G.S. Shadel, Z.J. Chen, A. Iwasaki, R.A. Flavell. Cell. 2014. 159(7):1563-77. 
Highlight by: K. Minton. Cell death: Silencing the immune response of apoptotic cells. Nature Reviews in Immunology. 15(2):68-9

PARP12, an Interferon-stimulated Gene Involved in the Control of Protein Translation and Inflammation. I. Welsby, D. Hutin, C. Gueydan, V. Kruys, A. Rongvaux, O. Leo. Journal of Biological Chemistry. 2014. 289:26642-57.

Development and function of human innate immune cells in a humanized mouse model. A. Rongvaux, Tim Willinger, J. Martinek, T. Strowig, S.V. Gearty, L.L. Teichmann, Y. Saito, F. Marches, S. Halene, A.K. Palucka, M.G. Manz, R.A. Flavell. 2014. Nature Biotechnology. 32(4):364-72.
News and Views by: H. Spits. New models of human immunity. Nature Biotechnology. 32:335-6.

Procaspase-3 regulates fibronectin secretion and influences adhesion, migration and survival independently of catalytic function. M. Brentnall, D.B. Weir, A. Rongvaux, A.I. Marcus, L.H. Boise. Journal of Cell Science. 2014. 127:2217-26.


Human Hemato-Lymphoid System Mice: Current use and future potential for medicine. A. Rongvaux, H. Takizawa, T. Strowig, T. Willinger, E.E. Eynon, R.A. Flavell, M.G. Manz. Annual Review of Immunology. 2013. 31:635-74.

A pathway involving HDAC5, cFLIP and caspases regulates expression of the splicing regulator polypyrimidine tract binding protein in the heart. J. Ye, M. Llorian, M. Cardona, A. Rongvaux, R.S. Moubarak, J.X. Comella, R. Bassel-Duby, R.A. Flavell, E.N. Olson, C.W. Smith, D. Sanchis D. Journal of Cell Science. 2013. 126:1682-91.


NLRP10 is a NOD-like receptor essential to initiate adaptive immunity by dendritic cells. S.C. Eisenbarth, A. Williams, O.R. Colegio, H. Meng, T. Strowig, A. Rongvaux, J. Henao-Mejia, C.A. Thaiss, S. Joly, D.G. Gonzalez, L. Xu, L.A. Zenewicz, A.M. Haberman, E. Elinav, S.H. Kleinstein, F.S. Sutterwala, R.A. Flavell. Nature. 2012. 484(7395):510-3.


Improving human hemato-lymphoid-system mice by cytokine knock-in gene replacement. T. Willinger, A. Rongvaux, T. Strowig, M.G. Manz, R.A. Flavell. Trends in Immunology. 2011. 32(7):321-7.

Efficient differentiation and function of human macrophages in humanized CSF-1 mice. C. Rathinam, W.T. Poueymirou, J. Rojas, A.J. Murphy, D.M. Valenzuela, G.D. Yancopoulos, A. Rongvaux, E.E. Eynon, M.G. Manz, R.A. Flavell. Blood. 2011. 118(11):3119-28.

Transgenic expression of human signal regulatory protein alpha in Rag2-/-gamma(c)-/- mice improves engraftment of human hematopoietic cells in humanized mice. T. Strowig, A. Rongvaux, C. Rathinam, H. Takizawa, C. Borsotti, W. Philbrick, E.E. Eynon, M.G. Manz, R.A. Flavell. Proceedings of the National Academy of Sciences USA. 2011. 108(32):13218-23. 

Control of TH17 cells occurs in the small intestine. E. Esplugues, S. Huber, N. Gagliani, A.E. Hauser, T. Town, Y.Y. Wan, W. O'Connor Jr, A. Rongvaux, N. Van Rooijen, A.M. Haberman, Y. Iwakura, V.K. Kuchroo, J.K. Kolls, J.A. Bluestone, K.C. Herold, R.A. Flavell. Nature. 2011. 475(7357):514-8.

Metabolic stress boosts humoral responses in vivo independently of inflammasome and inflammatory reaction. F. Andris, S. Denanglaire, E. Baus, A. Rongvaux, J. Steuve, R.A. Flavell, O. Leo. Journal of Immunology. 2011. 186(4):2245-53.

Human thrombopoietin knockin mice efficiently support human hematopoiesis in vivo. A. Rongvaux, T. Willinger, H. Takizawa, C. Rathinam, W. Auerbach, A.J. Murphy, D.M. Valenzuela, G.D. Yancopoulos, E.E. Eynon, S. Stevens, M.G. Manz, R.A. Flavell. Proceedings of the National Academy of Sciences USA. 2011. 108(6):2378-83.

Human IL-3/GM-CSF knock-in mice support human alveolar macrophage development and human immune responses in the lung. T. Willinger, A. Rongvaux, H. Takizawa, G.D. Yancopoulos, D.M. Valenzuela, A.J. Murphy, W. Auerbach, E.E. Eynon, S. Stevens, M.G. Manz, R.A. Flavell. Proceedings of the National Academy of Sciences USA. 2011. 108(6):2390-5. 


A mouse model for the human pathogen Salmonella typhi. J. Song, T. Willinger, A. Rongvaux, E.E. Eynon, S. Stevens, M.G. Manz, R.A. Flavell, J.E. Galán. Cell Host & Microbe. 2010. 8(4):369-76. 

The nicotinamide phosphoribosyltransferase: a molecular link between metabolism, inflammation, and cancer. M. Gallí, F. Van Gool, A. Rongvaux, F. Andris, O. Leo. Cancer Research. 2010. 70(1):8-11.


Apoptosis is not required for mammalian neural tube closure. V. Massa, D. Savery, P. Ybot-Gonzalez, E. Ferraro, A. Rongvaux, F. Cecconi, R.A. Flavell R, N.D. Greene, A.J. Copp. Proceedings of the National Academy of Sciences USA. 2009. 106(20):8233-8238.

Humanized mice for modeling human infectious disease: challenges, progress, and outlook. N. Legrand, A. Ploss, R. Balling, P.D. Becker, C. Borsotti, N. Brezillon, J. Debarry, Y. de Jong, H. Deng, J.P. Di Santo, S. Eisenbarth, E. Eynon, R.A. Flavell, C.A. Guzman, N.D. Huntington, D. Kremsdorf, M.P. Manns, M.G. Manz, J.J. Mention, M. Ott, C. Rathinam, C.M. Rice, A. Rongvaux, S. Stevens, H. Spits, H. Strick-Marchand, H. Takizawa, A.U. van Lent, C. Wang, K. Weijer, T. Willinger, P. Ziegler. Cell Host & Microbe. 2009. 6(1):5-9. 


Nicotinamide phosphoribosyl transferase/Pre-B Cell Colony-Enhancing Factor/Visfatin is required for lymphocyte development and cellular resistance to genotoxic stress. A. Rongvaux, M. Galli, S. Denanglaire, F. Van Gool, P.L. Dreze, C. Szpirer, F. Bureau, F. Andris, O. Leo. Journal of Immunology. 2008. 181(7):4685-4695. 

Granzyme B-induced cell death exerted by ex vivo CTL: discriminating requirements for cell death and some of its signs. J. Pardo, R. Wallich, P. Martin, C. Urban, A. Rongvaux, R.A. Flavell, A. Müllbacher, C. Borner, M.M. Simon. Cell Death and Differentiation. 2008. 15(3):567-579.


Pro-inflammatory properties for thiazolidinediones. C. Desmet, B. Warzee, P. Gosset, D. Melotte, A. Rongvaux, L. Gillet, L. Fievez, G. Seumois, A. Vanderplasschen, B. Staels, P. Lekeux, F. Bureau. Biochemical Pharmacology. 2005. 69(2):255-265.


Reconstructing eukaryotic NAD metabolism. A. Rongvaux, F. Andris, F. Van Gool, O. Leo. Bioessays. 2003. 25(7): 683-690. 


Pre-B-cell colony-enhancing factor, whose expression is up-regulated in activated lymphocytes, is a nicotinamide phosphoribosyltransferase, a cytosolic enzyme involved in NAD biosynthesis. A. Rongvaux, R. J. Shea, M. H. Mulks, D. Gigot, J. Urbain, O. Leo F. Andris. European Journal of Immunology. 2002. 32: 3225-3234.