Overbaugh/Lehman Lab Members

Julie Overbaugh, PhD

Julie Overbaugh, PhD

Title: Principal Investigator

Member, Human Biology and Public Health Sciences Division
Associate Director for Education and Career Enhancement
Endowed Chair of Graduate Studies
Affiliate Professor, University of Washington
Director, Office of Education and Training, Fred Hutch/UW Cancer Consortium
Director, Viral Pathogenesis and Evolution Training Program

Dara Lehman, PhD

Dara Lehman, PhD

Title: Senior Staff Scientist

2003-present

Daryl Humes, PhD

Daryl Humes, PhD

Title: Staff Scientist

2006-present
My major project involves using CRISPR-Cas9 technology to define the dominant effectors of the type-I interferon response against HIV-1 in primary target CD4+T cells.  I have also been involved in projects involving the type I interferon response against ZIKA virus and chimeric SIV/HIV viruses (SHIVs).

Adam Dingens, PhD

Adam Dingens, PhD

Title: Staff Scientist

2014-present
I am interested in identifying immune correlates of susceptibility to superinfection. I am also working on developing new approaches to comprehensive epitope mapping of monoclonal antibodies and plasma responses.

Laura Doepker, PhD

Laura Doepker, PhD

Title: Postdoctoral Fellow

2016-present
I study the evolution of human antibody responses directed against HIV-1 infection.  We sequence antibody genes from B cells within longitudinal patient blood samples to estimate how their HIV-specific antibody lineages developed.

Joshua Marceau, PhD

Joshua Marceau, PhD

Title: Postdoctoral Fellow

2018-present
I am interested in defining which interferon-stimulated genes are involved in the restriction of lentiviruses.

Mackenzie Shipley, PhD

Mackenzie Shipley, PhD

Title: Postdoctoral Fellow

2019-present
I am currently working on isolating and characterizing HIV-specific broadly neutralizing antibodies from women who are superinfected with HIV-1. Superinfection with two distinct viral strains generates a broad polyclonal repertoire of neutralizing antibodies targeted to HIV. Understanding how these antibodies evolve and develop may assist future vaccine design.

Meghan Garrett

Meghan Garrett

Title: Graduate Research Assistant

2017-present
I am interested in studying the function and epitope of antibodies that potentially mediate protection from HIV, with the goal of informing HIV vaccine design.

Ted Gobillot

Ted Gobillot

Title: Graduate Research Assistant

2015-present
I am examining Zika virus as a cause of fever in Kenya and studying the role of type-I interferon in restricting Zika virus replication.

 

Hannah Itell

Hannah Itell

Title: Graduate Research Assistant

2019-present
I am interested in applying high-throughput techniques to identify interferon-induced genes that are potent inhibitors of early viral infection and replication (restriction factors).

Zak Yaffe

Zak Yaffe

Title: Graduate Research Assistant

2019-present
I am interested in studying the evolution of both neutralizing and non-neutralizing antibodies in HIV-1 infected individuals. I would also like to better understand how effector functions influence whether a given antibody will be beneficial or detrimental in the context of HIV infection.

Noah Cassidy

Noah Cassidy

Title: Research Technician

2018-present
I am interested in the characterization of viral diversity and evolution in HIV infected infants as well as the ability to quantify the HIV-1 latent reservoir with novel ddPCR methods.

Vrasha Chohan

Vrasha Chohan

Title: Research Technician

2008-present
I perform Gen Probe QC HIV viral RNA loads and population based sequencing for resistant mutations for women on ARV for the QRS cohort. I’ve also been involved with neutralization assays using the PBMC and TZM methods for PBMC and 293T-passaged chimeras with monoclonal antibodies.

 

Sonja Danon

Sonja Danon

Title: Research Technician

2019-present
I am studying the evolution of antibodies that mediate antibody-dependent cellular cytotoxicity; I am focused specifically on characterizing gp120-directed antibodies.

Carolyn Fish

Carolyn Fish

Title: Research Technician

2019-present
I am interested in studying the diversity and evolution of HIV-1 in Kenyan infants to understand the timing of infection.

 

Caroline Kikawa

Caroline Kikawa

Title: Research Technician

2018-present
Currently, I'm involved in projects designed to study the interface between Zika virus and type-I interferon, a critical component of the innate immune response. Additionally, I'm interested in characterizing Zika virus presence in eastern Africa and its contribution to febrile illness.

Stephanie Rainwater

Stephanie Rainwater

Title: Research Technician

1993-present
I've been a member of Julie's lab since 1993; first as an undergraduate then as a tech. I've been involved in a number of different projects over the years, most pertaining to cloning and characterizing HIV-1 envelopes. I'm also currently working on cloning HIV-1 specific antibodies.

Vera Okolo

Vera Okolo

Title: Research Intern

2019-present
I’m interested in exploring viral diversity and evolution in HIV-1 infected Kenyan infants and how it relates to antibody breadth.

Shama Samant

Shama Samant

Title: Research Administrator
Phone: 206.667.5409

2015-present

Jasmine Gonzalez

Jasmine Gonzalez

Title: Research Administrator
Phone: 206.667.4923

2018-present