The McGuire lab in the Vaccine and Infectious Disease Division of Fred Hutch seeks enthusiastic, organized, and independent graduate students and post-doctoral research fellows who are interested in developing immunology, biochemistry or vaccinology skills.
The successful candidate will design and execute prime-boost immunization regimens in a humanized murine model which will serve as a surrogate for human vaccine trials. The candidate will perform endpoint analyses including antigen-specific B cell sorting and serum antibody binding and neutralization assays to gain a high-resolution understanding of the immune response to immunization. To complement this analysis the candidate will perform single B cell sorting of human PBMC samples ascertain the identity of antigen-reactive naïve B cells.
The successful candidate will design and execute antibody-mediated protection studies in in small animals and non-human primates to evaluate the efficacy of antibodies, both passively delivered and vaccine-elicited, to prevent infection and/or EBV-associated cancers. The incumbent will perform endpoint analyses including serum antibody neutralizing titers, assays for detecting viral infection, and analyzing immune responses to treatment/vaccination.