Lee Lab

Lee Lab

Heatmap of RNA-seq gene expression data showing differential gene expression in prostate cancer samples

Heatmap of RNA-seq gene expression data showing differential gene expression in prostate cancer samples

Fluorescent imaging of a 384-well screening plate seeded with GFP reporter cells and treated with a small molecule inhibitor library

Fluorescent imaging of a 384-well screening plate seeded with GFP reporter cells and treated with a small molecule inhibitor library

Photomicrograph of the immunohistochemical staining of a normal human tissue microarray

Photomicrograph of the immunohistochemical staining of a normal human tissue microarray

Brightfield and fluorescent images of a prostate cancer bone metastasis involving a mouse femur

Brightfield and fluorescent images of a prostate cancer bone metastasis involving a mouse femur

Our Research


Welcome to the Lee laboratory. Our aim is to identify molecular drivers and biological properties of prostate and bladder cancer that may be exploited for the development of new and effective treatments. In our research we employ cutting-edge technologies including mouse and human epithelial transformation systems; functional genomics; multi-omic data integration; high-throughput screening; small molecule drug discovery; and immuno-oncology to develop new approaches to stratify and treat prostate and bladder cancer.
 

Publications

Science 2018

Reprogramming normal human epithelial tissues to a common, lethal neuroendocrine cancer lineage. Park JW, Lee JK, Sheu KM, Wang L, Balanis NG, Nguyen K, Smith BA, Cheng C, Tsai BL, Cheng D, Huang J, Kurdistani SK, Graeber TG, Witte ON.

Proceedings of the National Academy of Sciences 2018

Systemic surfaceome profiling identifies target antigens for immune-based therapy in subtypes of advanced prostate cancer. Lee JK, Bangayan NJ, Chai T, Smith BA, Pariva TE, Yun S, Vashisht A, Zhang Q, Park JW, Corey E, Huang J, Graeber TG, Wohlschlegel J, Witte ON.

Cancer Cell 2016

N-Myc Drives Neuroendocrine Prostate Cancer Initiated from Human Prostate Epithelial Cells. Lee JK, Phillips JW, Smith BA, Park JW, Stoyanova T, McCaffrey EF, Baertsch R, Sokolov A, Meyerowitz JG, Mathis C, Cheng D, Stuart JM, Shokat KM, Gustafson WC, Huang J, Witte ON.

 

News from the Lab

October 23, 2019

Shan and Diana both receive word that their Department of Defense Prostate Cancer Research Program Early Research Investigator Award applications are recommended for funding! Congratulations!

August 16, 2019

We bid farewell to Tanushri who finished the summer off strong by winning a Lee Hartwell Award! We look forward to following your growth and success in science.

 

August 1, 2019

The Lee Lab and a team of investigators from Fred Hutch (Nelson Lab and Vicky Wu) and Seattle Children's Hospital (Jensen Lab, Julie Park, and Navin Pinto) are awarded a Movember Foundation-PCF Challenge Award to pursue preclinical and clinical studies related to therapeutic targeting of L1CAM in neuroendocrine prostate cancer with chimeric antigen receptor T cell immunotherapy.