Lee Lab

Lee Lab

Heatmap of RNA-seq gene expression data showing differential gene expression in prostate cancer samples

Heatmap of RNA-seq gene expression data showing differential gene expression in prostate cancer samples

Fluorescent imaging of a 384-well screening plate seeded with GFP reporter cells and treated with a small molecule inhibitor library

Fluorescent imaging of a 384-well screening plate seeded with GFP reporter cells and treated with a small molecule inhibitor library

Photomicrograph of the immunohistochemical staining of a normal human tissue microarray

Photomicrograph of the immunohistochemical staining of a normal human tissue microarray

Brightfield and fluorescent images of a prostate cancer bone metastasis involving a mouse femur

Brightfield and fluorescent images of a prostate cancer bone metastasis involving a mouse femur

Our Research


Welcome to the Lee laboratory. Our aim is to identify molecular drivers and biological properties of prostate and bladder cancer that may be exploited for the development of new and effective treatments. In our research we employ cutting-edge technologies including mouse and human epithelial transformation systems; functional genomics; multi-omic data integration; high-throughput screening; small molecule drug discovery; and immuno-oncology to develop new approaches to stratify and treat prostate and bladder cancer.
 

Publications

Science 2018

Reprogramming normal human epithelial tissues to a common, lethal neuroendocrine cancer lineage. Park JW, Lee JK, Sheu KM, Wang L, Balanis NG, Nguyen K, Smith BA, Cheng C, Tsai BL, Cheng D, Huang J, Kurdistani SK, Graeber TG, Witte ON.

Proceedings of the National Academy of Sciences 2018

Systemic surfaceome profiling identifies target antigens for immune-based therapy in subtypes of advanced prostate cancer. Lee JK, Bangayan NJ, Chai T, Smith BA, Pariva TE, Yun S, Vashisht A, Zhang Q, Park JW, Corey E, Huang J, Graeber TG, Wohlschlegel J, Witte ON.

Cancer Cell 2016

N-Myc Drives Neuroendocrine Prostate Cancer Initiated from Human Prostate Epithelial Cells. Lee JK, Phillips JW, Smith BA, Park JW, Stoyanova T, McCaffrey EF, Baertsch R, Sokolov A, Meyerowitz JG, Mathis C, Cheng D, Stuart JM, Shokat KM, Gustafson WC, Huang J, Witte ON.

 

News from the Lab

February 27, 2019

John is awarded a Career Development Award from the Department of Defense Peer Reviewed Cancer Research Program for multiplex functional interrogation of oncogenic networks in bladder cancer.

February 14, 2019

Diana and Shan are selected to present posters at the 12th Annual Multi-Institutional Prostate Cancer Retreat in Ft. Lauderdale, FL on March 4, 2019. Congratulations!

December 6, 2018

John gives a presentation detailing the transformation of human prostate epithelial cells to variant prostate cancer differentiation states at the National Cancer Institute Workshop on Lineage Plasticity and AR-independent Prostate Cancer held at the National Institutes of Health in Bethesda, MD.