Lee Lab

Lee Lab

Heatmap of RNA-seq gene expression data showing differential gene expression in prostate cancer samples

Heatmap of RNA-seq gene expression data showing differential gene expression in prostate cancer samples

Fluorescent imaging of a 384-well screening plate seeded with GFP reporter cells and treated with a small molecule inhibitor library

Fluorescent imaging of a 384-well screening plate seeded with GFP reporter cells and treated with a small molecule inhibitor library

Photomicrograph of the immunohistochemical staining of a normal human tissue microarray

Photomicrograph of the immunohistochemical staining of a normal human tissue microarray

Brightfield and fluorescent images of a prostate cancer bone metastasis involving a mouse femur

Brightfield and fluorescent images of a prostate cancer bone metastasis involving a mouse femur

Our Research


Welcome to the Lee laboratory. Our aim is to identify molecular drivers and biological properties of prostate and bladder cancer that may be exploited for the development of new and effective treatments. In our research we employ cutting-edge technologies including mouse and human epithelial transformation systems; functional genomics; multi-omic data integration; high-throughput screening; small molecule drug discovery; and immuno-oncology to develop new approaches to stratify and treat prostate and bladder cancer.
 

Publications

Science 2018

Reprogramming normal human epithelial tissues to a common, lethal neuroendocrine cancer lineage. Park JW, Lee JK, Sheu KM, Wang L, Balanis NG, Nguyen K, Smith BA, Cheng C, Tsai BL, Cheng D, Huang J, Kurdistani SK, Graeber TG, Witte ON.

Proceedings of the National Academy of Sciences 2018

Systemic surfaceome profiling identifies target antigens for immune-based therapy in subtypes of advanced prostate cancer. Lee JK, Bangayan NJ, Chai T, Smith BA, Pariva TE, Yun S, Vashisht A, Zhang Q, Park JW, Corey E, Huang J, Graeber TG, Wohlschlegel J, Witte ON.

Cancer Cell 2016

N-Myc Drives Neuroendocrine Prostate Cancer Initiated from Human Prostate Epithelial Cells. Lee JK, Phillips JW, Smith BA, Park JW, Stoyanova T, McCaffrey EF, Baertsch R, Sokolov A, Meyerowitz JG, Mathis C, Cheng D, Stuart JM, Shokat KM, Gustafson WC, Huang J, Witte ON.

 

News from the Lab

June 4, 2018

The Lee Lab moves to the Eastlake Building to join the shared Prostate Cancer Laboratory with the Nelson and Vasioukhin Labs.

April 23, 2018

Our manuscript describing the surfaceome profiling of advanced prostate cancer is published in PNAS. 

March 1, 2018

The Lee Lab opens!