Lee Lab

Lee Lab

Heatmap of RNA-seq gene expression data showing differential gene expression in prostate cancer samples

Heatmap of RNA-seq gene expression data showing differential gene expression in prostate cancer samples

Fluorescent imaging of a 384-well screening plate seeded with GFP reporter cells and treated with a small molecule inhibitor library

Fluorescent imaging of a 384-well screening plate seeded with GFP reporter cells and treated with a small molecule inhibitor library

Photomicrograph of the immunohistochemical staining of a normal human tissue microarray

Photomicrograph of the immunohistochemical staining of a normal human tissue microarray

Brightfield and fluorescent images of a prostate cancer bone metastasis involving a mouse femur

Brightfield and fluorescent images of a prostate cancer bone metastasis involving a mouse femur

Our Research


Welcome to the Lee laboratory. Our aim is to identify molecular drivers and biological properties of prostate and bladder cancer that may be exploited for the development of new and effective treatments. In our research we employ cutting-edge technologies including mouse and human epithelial transformation systems; functional genomics; multi-omic data integration; high-throughput screening; small molecule drug discovery; and immuno-oncology to develop new approaches to stratify and treat prostate and bladder cancer.
 

Publications

Science 2018

Reprogramming normal human epithelial tissues to a common, lethal neuroendocrine cancer lineage. Park JW, Lee JK, Sheu KM, Wang L, Balanis NG, Nguyen K, Smith BA, Cheng C, Tsai BL, Cheng D, Huang J, Kurdistani SK, Graeber TG, Witte ON.

Proceedings of the National Academy of Sciences 2018

Systemic surfaceome profiling identifies target antigens for immune-based therapy in subtypes of advanced prostate cancer. Lee JK, Bangayan NJ, Chai T, Smith BA, Pariva TE, Yun S, Vashisht A, Zhang Q, Park JW, Corey E, Huang J, Graeber TG, Wohlschlegel J, Witte ON.

Cancer Cell 2016

N-Myc Drives Neuroendocrine Prostate Cancer Initiated from Human Prostate Epithelial Cells. Lee JK, Phillips JW, Smith BA, Park JW, Stoyanova T, McCaffrey EF, Baertsch R, Sokolov A, Meyerowitz JG, Mathis C, Cheng D, Stuart JM, Shokat KM, Gustafson WC, Huang J, Witte ON.

 

News from the Lab

May 21, 2019

John is awarded a New Investigator Idea Development Award from the Department of Defense Prostate Cancer Research Program to optimize chimeric antigen receptor T cell therapy using autologous human prostate cancer tissue slice co-cultures with collaborators at the City of Hope and the University of Washington.

May 8, 2019

Alicia receives a Human Biology Division Conference Travel Award to present her work at the AACR Special Conference on Bladder Cancer: Transforming the Field in Denver, CO from May 18-21, 2019. Congratulations!

March 29, 2019

The lab is awarded a Safeway Early Career Award in Cancer Research from the Fred Hutch/University of Washington Cancer Consortium to target prostate cancer with chimeric antigen receptor T cell therapy.