Diet and Systemic Inflammation (DASI)

Low-grade chronic systemic inflammation is a risk factor for type 2 diabetes mellitus (T2DM), cardiovascular disease (CVD), and several types of cancer. While it is known that obesity is associated with inflammation, the cause of low-grade inflammation in humans is not well understood. Data from a previous pilot study by our group as well as several experiments in rodent models indicated that the consumption of large amounts of fructose- but not glucose-sweetened beverages induces low-grade systemic inflammation in a manner largely independent of increased adiposity. The DASI study was designed to test whether fructose-sweetened beverages trigger low-grade systemic inflammation in healthy men and women who are normal weight to obese. Twenty-five participants were enrolled into this double-blind randomized cross-over design trial where every subject completed three 8-day standardized dietary periods that differed only in the type of sweetened beverage administered. Specifically, we compared how consumption of four servings daily of a beverage sweetened with glucose, fructose, or high fructose corn syrup impacted markers of systemic low-grade inflammation (C-reactive protein, interleukin-6, and adiponectin), intestinal permeability, adipose tissue inflammation, and ad libitum energy intake from a standardized diet.

Status: completed, additional statistical analyses in progress (as of April 2016)
Clinicaltrials.gov: NCT01424306
Publications:

Kuzma JN, Cromer G, Hagman DK, Breymeyer K, Bates P, Roth CL, Foster-Schubert KE, Holte S, Callahan HS, Weigle DS, Kratz M. No difference in ad libitum energy intake in healthy men and women consuming beverages sweetened with fructose, glucose, or high-fructose corn syrup: a randomized trial. American Journal of Clinical Nutrition 2015; 102: 1373-80. (with link to PubMed site)