Siobhan Pattwell


Postdoctoral Fellow

BS, Neuroscience (2006)
Lafayette College, Easton, PA

PhD, Neuroscience (2012)
Weill School of Biomedical Sciences, Cornell University, NY

Research Interests

With a background in neuroscience, I have long been interested in the brain's capacity for change - both in normal and abnormal plasticity.  Combining my interests in neuroscience and cancer, I am now utilizing mouse models of glioma to study how intrinsic properties of specific glioma subtypes, particularly GBM, prohibit successful treatment outcomes. By exploring the role of growth factor receptors in brain tumor development, I hope to gain a better understanding of what makes certain tumors more aggressive and subsequently treatment resistant.



  • Pattwell, S. S., Bath, K.G. (2017) Emotional learning, stress, and development: An ever-changing landscape shaped by early-life experience. Neurobiol Learn & Mem, 143: 36 – 48. PMCIDPMC5540880 
  • Pattwell, S.S., Holland, E.C. (2017) Putting glioblastoma in its place: IRF3 inhibits invasion. Trends Mol Med, 23(9): 773-776. PMID: 28774478
  • Pattwell, S. S., Liston, C., Jing, D. Q., Ninan, I., Yang, R. R., Casey, B. J., Deisseroth, K., Lee, F. S. Dynamic changes in neural circuitry during adolescence are associated with persistent attenuation of fear memories. (2016) Nature Communications, 7: 11475.  PMCID: PMC4890178
  • Pitter, K. L., Tamagno, I., Hosni-Ahmed, A., Pattwell, S. S., Donnola, S., Dai, C., Ozawa, T., Chang, M., Chan, T. A., Beal, K., Bishop, A. J., Barker, C. A., Jones, T. S., Hentschel, B., Gorlia, T., Schlegel, U., Stupp, R., Weller, M., Holland, E. C., Hambardzumyan, D. (2016) Corticosteroids compromise survival in glioblastoma. Brain, PMID: 27020328
  • Halliday, J., Helmy, K., Pattwell, S. S., Pitter, K. L., Laplant, Q., Ozawa, T., Holland, E. C. (2014) In vivo radiation response of proneural glioma characterized by protective p53 transcriptional program and proneural-mesenchymal shift. PNAS, 111(14):5248-53. PMCID: PMC3986190
  • Dincheva, I*., Pattwell, S. S.,* Tessarollo, L., Casey, B. J., Lee, F. S. (2014) Role of the BDNF Val66Met polymorphism in modulating contextual fear learning during adolescence. Dev Neurosci, 36(3-4):269-76. (*Co-first author) PMCID: PMC4150737
  • King, E. C., Pattwell, S. S., Sun, A., Glatt, C. E., Lee, F.S. (2013) Nonlinear developmental trajectory of fear learning and memory. Ann NY Acad Sci, 1304:62-9. PMCID: PMC4155981
  • Drysdale, A. T., Hartley, C. A., Pattwell, S. S., Ruberry, E. J., Somerville, L. H., Lee, F. S., Casey, B. J., Walkup, J. T. (2014) Fear and Anxiety from Principle to Practice: Implications for when to treat youth with anxiety disorders. Biol Psychiatry, 75(11). PMCID: PMC4372462
  • King, E. C., Pattwell, S. S., Glatt, C. E. Lee, F. S. (2014) “Sensitive Periods in Fear Learning and Memory.” Stress, 17(1):13-21. PMCID: PMC4336785
  • Pattwell, S. S., Mouly, A. M., Sullivan, R. M., Lee, F. S. (2013) Developmental components of fear and anxiety in animal models. Neurobiology of Mental Illness, 4th Edition, Edited by Dennis S. Charney, Joseph D. Buxbaum, Pamela Sklar, and Eric J. NestlerISBN: 9780199934959
  • Pattwell, S. S., Lee, F. S., Casey, B. J. (2013) Fear learning and memory across development. Hormones and Behavior, Special Issue: Puberty and Adolescence, 64(2):380-9. PMID: 23998679
  • Pattwell, S. S., Casey, B.J., Lee, F. S. (2013) The teenage brain: Altered fear in humans and mice. Curr Dir Psychol Sci. 22(2):146-151. PMCID: PMC4415656
  • Riddle, M. C., McKenna, M. C., Yoon, Y. J., Pattwell, S. S., Santos, P. M., Casey, B. J., Glatt, C. E. (2013). Caloric Restriction Enhances Fear Extinction Learning in Mice. Neuropsychopharmacology, 38(6): 930-37. PMCID: PMC3629393
  • Casey, B. J., Pattwell, S. S., Glatt, C. E., Lee, F. S. (2013). Treating the developing brain: implications from human imaging and mouse genetics. Annu Rev Med 64: 427-39. PMID: 23190151
  • Pattwell, S. S., Duhoux, S., Hartley, C. A., Johnson, D. C., Jing, D. Q., Ruberry, E. J., Powers, A., Mehta, N., Soliman, F., Glatt, C. E., Casey, B. J., Ninan, I., Lee, F. S. (2012). Altered fear learning across development in both mouse and human. PNAS, 109(40):16318-23. PMCID: PMC3479553
  • Pattwell, S. S., Bath, K. G., Perez-Castro, R., Lee, F. S., Chao, M. V., & Ninan, I. (2012). The BDNF Val66Met polymorphism impairs synaptic transmission and plasticity in the infralimbic medial prefrontal cortex. The Journal of Neuroscience, 32(7), 2410-21. PMCID: PMC3532006
  • Bath, K. G., Jing, D. Q., Dincheva, I., Neeb, C. C., Pattwell, S. S., Chao, M. V., Lee, F. S., & Ninan, I. (2012). BDNF impairs fluoxetine-induced enhancement of adult hippocampus plasticity. Neuropsychopharmacology37(5):1297-304PMCID: PMC3306891
  • Pattwell, S. S., Bath, K. G., Casey, B. J., Ninan, I., Lee, F. S. (2011). Selective early-acquired fear memories undergo temporary suppression during adolescence. PNAS, 108(3): 1182-1187. PMCID: PMC3024661
  • Casey, B. J., Jones, R. M., Levita, L., Libby, V., Pattwell, S. S., Ruberry, E. J., Soliman, F., Sommerville, L. H. (2010). The storm and stress of adolescence: insights from human imaging and mouse genetics.  Devopmental Psychobiology, 52(3): 225-235. PMCID: PMC2850961
  • Soliman F., Glatt C. E., Bath K. G., Levita L., Jones R. M., Pattwell, S. S., Jing, D., Tottenham, N., Amso, D., Somerville, L. H., Voss, H. U., Glover, G., Ballon, D. J., Liston, C., Teslovich, T., Van Kempen, T., Lee, F. S., Casey, B.J. (2010) A genetic variant BDNF polymorphism alters extinction learning in both mouse and human.  Science, 327(5967): 863-866. PMCID: PMC2829261
  • Casey, B. J., Glatt, C. E., Tottenham, N., Soliman, F., Bath, K., Amso, D., Altemus, M., Pattwell, S., Jones, R., Levita, L., McEwen, B., Magariños, A. M., Gunnar, M., Thomas, K. M., Mezey, J., Clark, A. G., Hempstead, B. L., Lee, F. S.  (2009) Brain-derived neurotrophic factor as a model system for examining gene by environment interactions across development. Neuroscience, 164(1): 108-120. PMCID: PMC2760671
  • Yu, H*., Wang, Y*., Pattwell, S*., Jing, D., Liu, T., Zhang, Y., Bath, K., Lee, F., Chen, Z.  (2009). Variant BDNF Val66Met polymorphism affects extinction of conditioned aversive memory.  The Journal of Neuroscience, 29(13): 4056-4064. PMCID: PMC2668145 (Co-first author)