Welcome to the Holland Lab

The Holland lab works at the intersection of multiple disciplines to address the molecular basis of brain tumors and develop new approaches to their treatment. Our research focuses on developing mouse models of brain cancer that mimic the behavior of the disease in patients. Our work with mouse models has led to clinical trials in glioma patients. We also have developed imaging strategies to follow mouse brain tumors as they develop—a powerful system that is used to test promising new drugs with potential benefit for patients.

The Holland Lab's research focuses on:

  • using a system of postnatal gene transfer to study brain cancer formation in mice, providing a model for the development of gliomas and medulloblastomas;

  • demonstrating that stem-like cells are more sensitive to changes that can lead to cancer, providing clues to cancer development and its ability to evade treatment;

  • demonstrating the activity of a protein called Akt is elevated in human glioblastomas—a  finding that provided major insights into the development of this cancer.

  • and understanding the biology of therapeutic resopnse to radiation and chemotherapy.