Nicolas headshot_square

Nicolas R. Chuvin

Post-Doctoral Research Fellow

Ph.D., Molecular & Cellular Biology
Universite Claude Bernard Lyon 1, Lyon, France

M.S., Molecular & Cellular Biology
Ecole Normale Superieure de Lyon, Lyon, France

B.S., Fundamental Biology
Ecole Normale Superieure de Lyon, Lyon, France

nchuvin@fredhutch.org


RESEARCH INTERESTS

My background in the use of genetically engineered mouse models drives my research in pancreatic cancer.  I work to decipher the effect of newly developed therapeutic strategies and to find new drug combinations that are beneficial at a preclinical stage.

 

PUBLICATIONS

Chuvin N, Vincent DF, Pommier RM, Alcaraz LB, Gout J, Yacoub K, Caligaris C, Roger E, Cardot V, Kaniewski B, Martel S, Cintas C, Goddard-Léon S, Colombe A, Valantin J, Gadot N, Servoz E, Morton J, Goddard I, Guillermet J, Sansom OJ, Treilleux I, Valcourt U, Sentis S, Dubus P, Bartholin L. Acinar-to-ductal metaplasia induced by TGFβ facilitates KrasG12D-driven pancreatic tumorigenesis. In revision.

Pommier RM, Gout J, Vincent DF, Alcaraz LB, Chuvin N, Arfi V, Martel S, Kaniewski B, Devailly G, Fourel G, Bernard P, Moyret-Lalle C, Ansieau S, Puisieux A, Valcourt U, Sentis S, Bartholin L. TIF1γ suppresses tumor progression by regulating mitotic checkpoints and chromosomal stability. Cancer Res. 2015 Oct 15;75(20):4335-50.

Fitamant J, Kottakis F, Benhamouche S, Tian HS, Chuvin N, Parachoniak CA, Nagle JM, Perera RM, Lapouge M, Deshpande V, Zhu AX, Lai A, Min B, Hoshida Y, Avruch J, Sia D, Campreciós G, McClatchey AI, Llovet JM, Morrissey D, Raj L, Bardeesy N. YAP inhibition restores hepatocyte differentiation in advanced HCC, leading to tumor regression. Cell Rep. 2015 Mar 10. pii: S2211-1247(15)00173-4. PMCID: PMC4565791

Alcaraz LB, Exposito JY, Chuvin N, Pommier RM, Cluzel C, Martel S, Sentis S, Bartholin L, Lethias C, Valcourt U. Tenascin-X promotes epithelial-to-mesenchymal transition by activating latent TGF-β. J Cell Biol. 2014 May 12;205(3):409-28. PMCID: PMC4018787

Vincent DF, Gout J, Chuvin N, Arfi V, Pommier RM, Bertolino P, Jonckheere N, Ripoche D, Kaniewski B, Martel S, Langlois JB, Goddard-Léon S, Colombe A, Janier M, Van Seuningen I, Losson R, Valcourt U, Treilleux I, Dubus P, Bardeesy N, Bartholin L. Tif1γ suppresses murine pancreatic tumoral transformation by a Smad4-independent pathway. Am J Pathol. 2012 Jun;180(6):2214-21. PMCID: PMC3378851