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Christopher C. Dufort

Post-Doctoral Research Associate

Ph.D., Analytical Chemistry
Indiana University, Bloomington, IN

B.S., Chemistry
Western Washington University, Bellingham, WA

cdufort@fredhutch.org


RESEARCH INTERESTS

By exploring the role of the tumor microenvironment in pancreas cancer, I hope to gain a better understanding of what makes this cancer uniquely lethal and resistant to treatment.  I am interested in understanding the fundamental biophysics inherent to pancreas cancer and determining how these can be exploited to design novel therapeutic strategies with translational impact.

 

PUBLICATIONS

Wu L, Wu IC, DuFort CC, Carlson MA, Wu X, Chen L, Kuo CT, Qin Y, Yu J, Hingorani SR, Chiu DT. Photostable ratiometric Pdot probe for in vitro and in vivo imaging of hypochlorous acid. Journal of the American Chemical Society. 2017 May 24;139(20):6911-18.

Ou G, Tung J, Miroshnikova Y, DuFort C, Gutierrez E, Groisman A, Weaver VM. Visualizing mechanical modulation of nanoscale organization of cell-matrix adhesions. Integr Biol (Camb). 2016 Jul 11;8(7):795-804. PMCID: PMC4980125

DuFort C, Hingorani SR. Tension and transformation in pancreas cancer: Can phenotype break free from the chrysalis of genotype? Cancer Cell. 2016 Jun 13;29(6):780-2.

DuFort C, DelGiorno K, Hingorani SR. Mounting pressure in the microenvironment: Fluids, solids, and cells in pancreatic ductal adenocarcinoma. Gastroenterology. 2016 Jun;150(7):1545-1557.e2. PMCID: PMC4957812

DuFort C*, DelGiorno K*, Carlson M, Osgood R, Zhao C, Huang Z, Thompson C, Connor R, Thanos C, Brockenbrough J, Provenzano P, Frost G, Shepard H, Hingorani SR. Interstitial pressure in pancreatic ductual adenocarcinoma is dominated by a gel-fluid phase. Biophys J. 2016 May 10;110(9):2106-19. PMCID: PMC4939548

Kuo C, Thompson A, Elena Gallina M, Ye F, Johnson E, Sun W, Zhao M, Yu J, Wu I, Fujimoto B, DuFort C, Carlson M, Hingorani S, Paguirigan A, Radich J, Chiu D. Optical painting and fluorescence-activated sorting of single adherent cells labeled with photoswitchable Pdots. Nat Commun. 2016 Apr 27;7:11468. PMCID: PMC4853474

Rys J*, DuFort C*, Monteiro D, Baird M, Oses-Prieto J, Shreya C, Burlingame A, Davidson M, Alliston T. Discrete spatial organization of TGFbeta receptors couples receptor multimerization and signaling to cellular tension. Elife. 2015 Dec 10;4:e09300.PMCID: PMC4728123

Rubashkin M, Cassereau L, Bainer R, DuFort C, Yui Y, Oakes P, Ou G, Paszek M, Davidson M, Chen Y, Gardel M, Weaver VM. Force engages vinculin and promotes tissue transformation by enhancing PI3-kinase activation of Phosphatidylinositol (3,4,5)-triphosphate. Cancer Res. 2014 Sep 1;74(17):4597-611. PMCID: PMC4191931

Paszek M, DuFort C, Rossier O, Bainer R, Mouw J, Godula K, Hudak J, Lakins J, Wijekoon A, Cassereau L, Rubashkin M, Magbanua M, Thorn K, Davidson M, Rugo H, Park J, Hammer D, Giannone G, Bertozzi C, Weaver VM. The cancer cell glycocalyx mechanically primes integrin-dependent growth and survival. Nature. 2014 Jul 17;511(7509):319-25. PMCID: PMC4487551

DuFort C, Paszek M. Nanoscale cellular imaging with scanning angle interference microscopy. Methods Cell Biol. 2014;123:235-52.

Maller O, DuFort C, and Weaver VM. YAP forces fibroblasts to feel the tension. Nat Cell Biol. 2013 Jun;15(6):570-2.

Paszek M, DuFort C, Rubashkin M, Davidson M, Thorn K, Liphardt J, Weaver VM. Scanning angle interference microscopy reveals cell dynamics at the nanoscale. Nat Methods. 2012 Jul 1;9(8):825-7. PMCID: PMC3454456

Cassereau L, DuFort C, Weaver, WM. Morphogenesis: laying down the tracks. Nat Mater. 2012 May 22;11(6):490-2.

DuFort C, Paszek MJ, Weaver VM. Balancing forces: architectural control of mechanotransduction. Nat Rev Mol Cell Biol. 2011 May;12(5):308-19. PMCID: PMC3564968

DuFort C, Dragnea B. Bio-enabled synthesis of metamaterials. Annu Rev Phys Chem. 2010;61:323-44.

Aniagyei S, DuFort C, Kao CC, Dragnea B. Self-assembly approaches to nanomaterial encapsulation in viral protein cages. J Mater Chem. 2008 Jan 1;18(32):3763-3774. PMCID: PMC2756705

Sun J, DuFort C, Daniel MC, Murali A, Chen C, Gopinath K, Stein B, De M, Rotello VM, Holzenburg A, Kao CC, Dragnea B. Core-controlled polymorphism in virus-like particles. Proc Natl Acad Sci U S A. 2007 Jan 23;104(4):1354-9. PMCID: PMC1783121

Onuta TD, Waegele M, DuFort C, Schaich WL, Dragnea B. Optical field enhancement at cusps between adjacent nanoapertures. Nano Lett. 2007 Mar;7(3):557-64.

Huang XL, Bronstein LM, Retrum J, DuFort C, Tsvetkova I, Aniagyei S, Stein B, Stucky G, McKenna B, Remmes N, Baxter D, Kao CC, Dragnea B. Self-assembled virus-like particles with magnetic cores. Nano Lett. 2007 Aug;7(8):2407-16.

*These authors contributed equally to this work.