Saint Martin's University, Lacey, WA
I am interested in preclinical treatment studies that explore the role of the immune system in genetically engineered mouse models of pancreas cancer as well as the development of molecular imaging modalities to improve early detection in pancreas cancer patients.
Stromnes IM, Schmitt TM, Hulbert A, Brockenbrough JS, Nguyen HN, Cuevas C, Dotson AM, Tan X, Hotes JL, Greenberg PD, Hingorani SR. T cells engineered against a native antigen can surmount immunologic and physical barriers to treat pancreatic ductal adenocarcinoma. Cancer Cell. 2015 Nov 9;28(5):638-52. PMCID: PMC4724422
DuFort CC, DelGiorno KE, Carlson MA, Osgood RJ, Zhao C, Huang Z, Thompson CB, Connor RJ, Thanos CD, Scott Brockenbrough J, Provenzano PP, Frost GI, Michael Shepard H, Hingorani SR. Interstitial pressure in pancreatic ductal adenocarcinoma is dominated by a gel-fluid phase. Biophysical Journal. 2016 May 10;110(9):2106-19. PMCID: PMC4939548
Stromnes IM, Brockenbrough JS, Izeradjene K, Carlson MA, Cuevas C, Simmons RM, Greenberg PD, Hingorani SR. Targeted depletion of an MDSC subset unmasks pancreatic ductal adenocarcinoma to adaptive immunity. Gut. 2014;63(11):1769-81. PMCID: PMC4340484