Given the increased scrutiny and oversight from FDA for cell-based therapies, there is a critical need for improvements in the bench-to-bedside translation process. That is the niche that research activities in this laboratory have focused on. Largely funded through various program project resource cores and/or through associated user fees, our laboratory has been acquiring critical equipment and pre-clinical process development expertise, primarily in the areas of specific cell subset selection, culturing of therapeutic cells in large-scale closed systems, cryopreservation, and storage.