Signaling Networks as the Keys to Drug Discovery

Our lab is focused on understanding the details of how cells respond to external stimuli, both stimuli that are physiological and those that contribute to disease. Cells in multicellular organisms are functionally distinct, and their behavior is influenced by the surrounding cells and tissue, which is referred to as the microenvironment. The molecular networks that let cells respond to stimuli are complex, dynamic, and interconnected. Therefore, studying these networks requires multiple approaches. In addition to using systems biology and computational biology along with cell biology and pharmacology approaches, we are developing new techniques to investigate tissue-specific signaling networks, identify molecular targets for drug discovery, and identify new uses for existing medicines.