The Human Microbiome: What factors determine the constituents of the human genital tract, and how do microbial communities on mucosal surfaces impact health? We use molecular and cultivation approaches to study the ecology of human microbial communities with the goal of improving human health.
Pathogen Discovery: Many microbes have not been successfully cultivated in the laboratory, therefore molecular cultivation-independent methods are needed to detect them. We develop and deploy nucleic acid sequence-based methods for discovering novel pathogens linked to human disease.
Molecular Diagnostics: We seek to improve the detection of human pathogens by developing sensitive and specific diagnostic tests. These assays rely on the detection of microbial nucleic acid sequences in human tissue or body fluids. Our main focus is the use of PCR for the diagnosis of fungal infections in cancer patients, but we also develop assays for detecting other pathogen groups such as bacteria and viruses.
Treatment of Fungal Infections: We participate in clinical trials of new antifungal therapies for the treatment of fungal infections in cancer patients.