Corey Lab

Corey Lab

Corey lab group photo

Our Research


Welcome to the Corey Lab. Our lab focuses on the pathogenesis of chronic viral infections and host immune responses. This includes herpes simplex virus type 2 (HSV-2) and HIV. We use HSV as a model to study the tissue based immune system of the genital tract. Our studies indicate a diverse and unique set of tissue resident cells populate the genital tract and our work is devoted to identifying and understanding the role of these cells in disease pathogenesis. The ultimate goal for these projects is to develop immunotherapeutic methods to control subclinical HSV-2 reactivation and reduce the transmission to sexual partners. Our lab has also initiated several preclinical studies to use adoptive transfer of genetically engineered T cells to traffic to and be effectors in lymphoid follicles with a goal to eradicate HIV infections.

 

Publications

The Journal of Experimental Medicine 2017

Keratinocytes produce IL-17c to protect peripheral nervous systems during human HSV-2 reactivation. Peng T, Chanthaphavong RS, Sun S, Trigilio JA, Phasouk K, Jin L, Layton ED, Li AZ, Correnti CE, De van der Schueren W, Vazquez J, O'Day DR, Glass IA, Knipe DM, Wald A, Corey L, Zhu J. 

Procedings of the National Academy of Sciences 2017

Preventing acquisition of HIV is the only path to an AIDS-free generation. Corey L, Gray GE.

Mucosal Immunology 2017

Enrichment of herpes simplex virus type 2 (HSV-2) reactive mucosal T cells in the human female genital tract. Posavad CM, Zhao L, Dong L, Jin L, Stevens CE, Magaret AS, Johnston C, Wald A, Zhu J, Corey L, Koelle DM.

Recent News

HVTN 100 clinical trial findings advance HIV vaccine research and development

VIDD News | Aziel Gangerdine | June 26, 2018
An HIV vaccine regimen tested in an early-phase clinical trial elicited robust immune responses that appeared to be stronger than those observed in a landmark 2009 study showing that a vaccine can protect people from HIV infection.

When scientific hypotheses don’t pan out

Hutch News | Rachel Tompa | Feb. 16, 2018
Research studies are often built around an educated guess. What happens when those guesses are wrong?

10 highlights of Fred Hutch science in 2017

Hutch News | Sabin Russell and Susan Keown | Dec. 28, 2017
A look back at notable discoveries in cancer immunotherapy, HIV prevention and more