Smoking is a major cause of lung cancer, the most common fatal cancer worldwide. However, most people who smoke do not develop lung cancer. Dr. Chen's goal is to figure out if certain people develop lung cancer because of a lower ability to repair DNA damage from smoking in their lungs. Dr. Chen and her team also explored how this could be related to other risk factors for lung cancer, such as smoking and a low intake of antioxidant-rich fruits and vegetables.
1) Sakoda LC, Loomis MM, Doherty JA, Neuhouser ML, Barnett MJ, Thornquist MD, Weiss NS, Goodman GE, Chen C. Chromosome 15q24-25.1 variants, diet, and lung cancer susceptibility in cigarette smokers. Cancer Causes Control, 22(3):449-61, 2011. PMCID: PMC3042523.
2) Sakoda LC, Loomis ML, Doherty JA, Julianto L, Barnett, MJ, Neuhouser ML, Thornquist MD, Weiss NS, Goodman GE, Chen C. Germ line variation in nucleotide excision repair genes and lung cancer risk in smokers. Int J Mol Epidemio Genet, 3(1):1-17, 2012. PMCID: PMC3316453.
3) Doherty JA, Sakoda LC, Loomis MM, Barnett, MJ, Julianto L, Thornquist MD, Neuhouser ML, Weiss NS, Goodman GE, Chen C. DNA repair genotype and lung cancer risk in the Beta-Carotene and Retinal Efficacy Trial. Int J Mol Epidemio Genet. 2013; 4(1):11-34. PMID: 23565320, PMCID: PMC3612452.
ILCCO was established in 2004 to share data from case-control and cohort studies from around the world to evaluate genetic and environmental factors that may influence lung cancer risk and survival.
The Women's Health Initiative (WHI) is a long term national health study involving postmenopausal participants in 40 study centers in the U.S. Dr. Chen is a member of its Clinical Coordinating Center housed at the Fred Hutchinson Cancer Research Center and collaborates with WHI investigators who shared similar scientific interest.
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