Dr. Chapuis is an expert in hematopoietic stem cell transplantation and in developing novel ways to help a patient’s immune system target life-threatening viral infections and various malignancies. Building on positive results with adoptive transfer of T cells targeting specific antigens in HIV and melanoma, her Program in Immunology laboratory is focused on understanding the factors associated with successful therapies so that adoptive T cells therapies can be further optimized to better eliminate tumors.

With particular expertise in obtaining and validating T cell receptors (TCRs) that bind specific target antigens, generating antigen-specific T cells and preparing certified T cell products for patients, ongoing studies in the Chapuis lab aim to 1) improve the survival and intrinsic antitumor activity of adoptively transferred T cells and 2) modulate the immune “microenvironment” in the patient to improve therapeutic T cell activity. Clinical trials and correlative laboratory studies are underway for patients with myeloid leukemia, lung cancer and Merkel cell carcinoma.