Research in the Campbell Lab is focused on understanding how cells communicate and interact with their surroundings. We study a family of receptors that are critical for accurate cell communication: they transverse the cell membrane and relay external signal into the cell, as well as internal signal out. These receptors must be strictly regulated: dysregulation is associated with a myriad of pathologies including autoimmune, cardiac, pulmonary and blood diseases as well as cancer and infectious diseases. Our lab utilizes a broad range of strategies in biophysics, protein engineering, biochemistry, and cell biology. Concurrently, we are developing cryo-electron microscopy (cryoEM) methods — both computational and biochemical — to enhance structural detail and characterize the dynamics of membrane protein receptors.
"Cryo-EM reveals a mechanism of integrin-mediated TGF-β activation within the latent TGF-β complex." Campbell MG, Cormier A, Ito S, Seed RI, Bondesson AJ, Lou J, Marks JD, Baron JL, Cheng Y, Nishimura SL. Cell. 2020 Feb 6;180(3):490-501.e16.
"Movies of ice-embedded particles enhance resolution in electron cryo-microscopy." Campbell MG, Cheng A, Brilot AF, Moeller A, Lyumkis D, Veesler D, Pan J, Harrison SC, Potter CS, Carragher B, Grigorieff N. Structure. 2012; 20(11):1823–1828.