We seek to identify biomarkers that define susceptibility to infectious diseases and can also influence the progression and severity of infection. We are using studies of gene expression, proteomics, cytokine signatures, characterization of prior virologic exposure (VirScan) and genome-wide association studies (GWAS) to identify biomarkers that are associated with an increased or decreased risk of infection and disease progression. Specific associations between biomarkers and infection risk may allow us to design prevention strategies or interventions for high risk patients using surveillance, targeted drug therapy, and vaccination.
Figure to right: Negative (NPV) and positive (PPV) predictive values for different biomarkers by prevalence of Idiopathic pneumonia syndrome (IPS) versus pneumonia caused by human rhinovirus (HRV) or parainfluenza virus (PIV) following hematopoietic stem cell transplant. From: Seo et al. 2018. Diagnostic and Prognostic Plasma Biomarkers for Idiopathic Pneumonia Syndrome after Hematopoietic Cell Transplantation. Biology of Blood and Marrow Transplantation. 24(4): 678-686