Biggins Lab

Biggins Lab

Biggins lab group shot

Biggins lab members on top of a mountain

Biggins lab members_Hutch picnic

Our Research

Welcome to the Biggins Lab. Our goal is to understand the mechanisms that ensure accurate chromosome segregation and thus maintain genomic stability and prevent human disease. Sue Biggins, our Principal Investigator, is the Senior Vice President and Director of the Basic Sciences Division at Fred Hutch and an Investigator with The Howard Hughes Medical Institute.

We aim to understand how cells get the right chromosomes. Aneuploidy is the condition where cells contain the wrong number of chromosomes and it is the most common chromosomal abnormality in cancers and the cause of birth defects and other diseases. We therefore study the underlying mechanisms that regulate cell division and chromosome segregation to ensure accurate self-renewal, proliferation and development. We take an interdisciplinary approach that combines biochemical, biophysical, cell biological, genetic and structural approaches using yeast and human cells as model systems.

Publications

PNAS 2019

Koch LB, Opoku KN, Deng Y, Barber A, Littleton AJ, London, N, Biggins S, Asbury CL. Autophosphorylation is sufficient to release Mps1 kinase from native kinetochores.

Current Biology 2019

Leontiou I, London, N, May KM, Ma Y, Grzesiak L, Medina-Pritchard B, Amin P, Jevaprakash AA, Biggins S, Hardwich KG. The Bub1-TPR Domain Interacts Directly with Mad3 to Generate Robust Spindle Checkpoint Arrest.

Current Biology 2018

Suzuki A, Gupta A, Long SK, Evans R, Badger BL, Salmon ED, Biggins S, Bloom K. A Kinesin-5, Cin8, Recruits Protein Phosphatase 1 to Kinetochores and Regulates Chromosome Segregation.

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