Our research is focused on human acute myeloid leukemia (AML). We are particularly interested in the delineation of the clonal origin of AML, the molecular and phenotypic characterization of AML stem and progenitor cells, and the interaction between AML cells and their environment. An overarching goal of these laboratory-based studies is the development of targeted treatments aimed to eradicate disease-relevant AML cells, with CD33-directed therapies being one important example for our efforts. We are also involved in the early testing of novel drugs and innovative care approaches in patients with AML. Finally, we participate in collaborative projects utilizing large datasets that aim to improve diagnostic and prognostic tools in AML or, together with epidemiologists, study risk factors for the development of this hematological malignancy.