Publications

2020

Augert A, Mathsyaraja H, Ibrahim AH, Freie B, Geuenich MJ, Cheng P, Alibeckoff SP, Wu N, Hiatt JB, Basom R, Gazdar A, Sullivan LB, Eisenman RN, MacPherson D. MAX Functions as a Tumor Suppressor and Rewires Metabolism in Small Cell Lung Cancer. Cancer Cell. 2020 Jul 13;38:1-18.

Li Z, Ji BW, Dixit PD, Lien EC, Tchourine K, Hosios AM, Abbott KL, Westermark AM, Gorodetsky EF, Sullivan LB, Vander Heiden MG, Vitkup D. Cancer cells depend on environmental lipids for proliferation when electron acceptors are limited. bioRxiv. 2020, June 9.

Luengo A, Li Z, Gui DY, Sullivan LB, Zagorulya M, Do BT, Ferriera R, Naamati A, Ali A, Lewis CA, Thomas CJ, Spranger S, Matheson NJ, Vander Heiden MG. Increased demand for NAD+ relative to ATP drives aerobic glycolysis. bioRxiv. 2020, June 9.

Quon E, Hart ML, Sullivan LB. Redox debt leads to metabolic bankruptcy in tumors. Trends Cancer. 2020 May 1; 6(5):359-61.

2018

Sullivan LB. Metabolic frugality marks cancer cells for immune targeting. Cell. 2018 Sep 6; 275(6):1344-1346.

Sullivan LB*, Luengo A, Danai LV, Bush LB, Diehl FF, Hosios AM, Lau AN, Elmiligy S, Malstrom S, Lewis CA, Vander Heiden MG*. Aspartate is an Endogenous Metabolic Limitation for Tumour GrowthNat Cell Biol. 2018 Jul;20(7):782-788. (*Co-Corresponding Author)

McLellan CA, Vincent BM, Solos NV, Lancaster AK, Sullivan LB, Hartland CL, Youngsaye W, Filler SG, Whitesell L, Lindquist S. Inhibiting mitochondrial phosphate transport as an unexploited antifungal strategy. Nat Chem Biol. 2018 Feb;14(2):135-141.

2017

Sullivan LB. Extracellular Vesicles: Taking Metabolism on the Road. Nat Chem Biol. 2017 Aug 18;13(9):924-925.

2016

Sullivan LB, Gui DY, Vander Heiden MG. Altered metabolite levels in cancer: implications for tumor biology and cancer therapy. Nat Rev Cancer. 2016 Nov;16(11):680-693.

Gui DY*, Sullivan LB*, Luengo A, Davidson SM, Hosios AM, Bush LB, Gitego N, Thomas CJ, Vander Heiden MG. Environment dictates dependence on mitochondrial complex I for NAD+ and aspartate production and determines cancer cell sensitivity to metformin. Cell Metab. 2016 Nov 8;24(5):716-727. (*Co-First Author)

Pacold ME, Brimacombe KR, Chan SH, Rohde JM, Lewis CA, Swier LJ, Possemato R, Chen WW, Sullivan LB, Fiske BP, Cho S, Freinkman E, Birsoy K, Abu-Remaileh M, Shaul YD, Liu CM, Zhou M, Koh MJ, Chung H, Davidson SM, Luengo A, Wang AQ, Xu X, Yasgar A, Liu L, Rai G, Westover KD, Vander Heiden MG, Shen M, Gray NS, Boxer MB, Sabatini DM. A PHGDH inhibitor reveals coordination between serine synthesis and 1-carbon unit utilization. Nat Chem Biol. 2016 Jun; 12(6): 452-8.

Davidson SM, Papagiannakopoulos T, Olenchock BA, Heyman JE, Keibler MA, Luengo A, Bauer MR, Jha AK, O’Brien JP, Pierce KA, Gui DY, Sullivan LB, Wasylenko TM, Subbaraj L, Chin CR, Stephanopolous G, Mott BT, Jacks T, Clish CB, Vander Heiden MG. Environment Impacts the Metabolic Dependencies of Ras-Driven Non-Small Cell Lung Cancer. Cell Metab. 2016 Mar 8;23(3):517-28.

Olenchock BA, Moslehi J, Baik AH, Davidson SM, Williams JL, Gibson WJ, Pierce KA, Miller CM, Hanse EA, Kelekar A, Sullivan LB, Wagers AJ, Clish CB, Vander Heiden MG, Kaelin WG, Jr. EGLN1 Inhibition and Rerouting of α-Ketoglutarate Suffice for Remote Ischemic Protection. Cell. 2016 Feb 25; 164(5):884-95.

Hecht VC*, Sullivan LB*, Kimmerling RJ, Kim DH, Hosios AM, Stockslager MA, Stevens MM, Kang JH, Wirtz D, Vander Heiden MG, Manalis SR. Biophysical changes reduce energetic demand in growth factor-deprived lymphocytes. J Cell Biol. 2016 Feb 15;212(4):439-47. (*Co-First Author)

2015

Sullivan LB*, Gui DY*, Hosios AM, Bush LN, Freinkman E, Vander Heiden MG. Supporting aspartate biosynthesis is an essential function of respiration in proliferating cells. Cell. 2015 Jul 30; 162(3):552-63. (*Co-First Author)

2014

Sullivan LB, Chandel NS. Mitochondrial reactive oxygen species and cancer. Cancer Metab. 2014 Nov 28, 2:17.

Luengo A, Sullivan LB, Vander Heiden MG. Understanding the complex-I-ty of metformin action: limiting mitochondrial respiration to improve cancer therapy. BMC Biol. 2014 Oct 24;12:82.

Mullen AR, Hu Z, Shi X, Jiang L, Buroughs LK, Kovacs Z, Boriak R, Rakheja D, Sullivan LB, Linehan WM, Chandel NS, DeBerardinis RJ. Oxidation of alpha-ketoglutarate is required for reductive carboxylation in cancer cells with mitochondrial defects. Cell Rep. 2014 Jun 12;7(5):1679-90.

Wheaton WW, Weinberg S, Hamanaka RB, Soberanes S, Sullivan LB, Anso E, Glasauer A, Dufour E, Mutlu GM, Budinger GRS, Chandel, NS. Metformin inhibits mitochondrial complex I of cancer cells to reduce tumorigenesis. eLife. 2014 May 13;3

Sullivan LB, Chandel NS. Mitochondrial metabolism in TCA cycle mutant cancer cells. Cell cycle. 2014 Feb 1;13(3):347-8.

2013

Sullivan LB, Garcia-Martinez E, Mullen AR, Nguyen H, Dufour E, Sudarshan S, Yang Y, Linehan WM, Licht JD, Deberardinis RJ, Chandel NS The proto-oncometabolite fumarate binds glutathione to amplify ROS dependent signaling. Mol Cell. 2013 Jul 25;51(2):236-48.

2012

Sullivan LB, Santos JH, Chandel NS. Mitochondria and Telomeres: The promiscuous role of TIN2. Mol Cell. 2012 Sep 28;47(6):823-4.

2011

Mullen AR, Wheaton WW, Jin ES, Chen PH, Sullivan LB, Cheng T, Yang Y, Linehan WM, Chandel NS, DeBerardinis RJ. Reductive carboxylation supports growth in tumour cells with defective mitochondria. Nature. 2011 Nov 20;481(7381):385-8.