Journal Club

Crystals of a computationally designed protein
Crystals of a computationally designed protein Image by Lindsey Doyle

2019-2020 FHCRC Structural Biology and Molecular Biophysics Journal Club

Fred Hutch's Structural Biology and Molecular Biophysics Journal Club is held from 11:00 am - 12:00 pm on Thursdays in the Weintraub Building, room A3M-015.

Date Presenter Topic
November 7 Barry Stoddard

Anzalone, A.V., Randolph, P.B., Davis, J.R. et al. Search-and-replace genome editing without double-strand breaks or donor DNA. Nature (2019) DOI

Baranauskas, A., Paliksa, S., Alzbutas, G. et al. Generation and characterization of new highly thermostable and processive M-MuLV reverse transcriptase variants, PEDS, Volume 25, Issue 10, October 2012, Pages 657–668. DOI

November 21 Julian Simon Seidler et al. (2019) "Structure-based inhibitors halt prion-like seeding by Alzheimer’s disease–and tauopathy–derived brain tissue samples” J. Biol. Chem. 294 (44) 16451 - 16464. DOI
November 28 — Happy Thanksgiving!
December 5 OPEN  
December 12 OPEN  
December 19 Phil Bradley

Zhang, Y., Zhang, X., Ba, Z. et al. The fundamental role of chromatin loop extrusion in physiological V(D)J recombination. Nature 573, 600–604 (2019) DOI

Zhang, X., Zhang, Y., Ba, Z. et al. Fundamental roles of chromatin loop extrusion in antibody class switching. Nature 575, 385–389 (2019) DOI

December 26 — No Meetings...Happy Christmas, Hannakah, Kwanzaa, Festivus, etc.
January 2— Still No Meeting...Happy New Year
January 9 OPEN  
January 16 OPEN (Snow day!  Be safe out there....)
January 23 OPEN  
February 6 Safia Aljedani (Stamatatos/Pancera Lab)  “A bipartite structural organization defines the SERINC family of HIV-1 restriction factors”  (Pye et al. Nature Struct. Mol. Biol. Vol 27 January 2020 pages 78 - 83). DOI
February 20
Brittany Takushi (Stoddard Lab)
"The human coronavirus HCoV-229E S-protein structure and receptor binding" (Li et al. eLife 2019; 8: e51230).
February 27 Connor Weidle (Pancera/Stamatatos Lab) microED workshop review
March 26 - online Lindsey Doyle (Stoddard Lab) Suo et al., Structural Insights into Electrophile Irritant Sensing by the Human TRPA1 Channel, Neuron (2019). DOI
April 10 - online Nick Hurlburt (Stamatatos/Pancera Lab)

Jizong Wang, et al. "Reconstitution and structure of a plant NLR resistosome conferring immunity" Science 05 Apr 2019: Vol. 364, Issue 6435, eaav5870
DOI: 10.1126/science.aav5870

Jizong Wang, et al. "Ligand-triggered allosteric ADP release primes a plant NLR complex" Science 05 Apr 2019: Vol. 364, Issue 6435, eaav5868
DOI: 10.1126/science.aav5868

April 16 - online Rachel Werther (Stoddard Lab)

Yin et al. (2019) “A complex structure of arrestin-2 bound to a G protein-coupled receptor” Cell Research 29971 - 29983.

Wingler et al. (2020) “Angiotensin and biased analogus induce structurally distinct active conformation within a GPCR” Science 367: 888 - 892.  

April 30 - online Natalia Ubilla (Stoddard Lab)
Bart et al. 2020) "Structure of an ancestral mammalian family 1B1 cytochrome P450 with increased thermostability” J. Biol. Chem. epub ahead of print (
May 14 - online Madison Kennedy (Stoddard Lab/UW)

Justin A. Caravella, et al. "Structure-Based Design and Identification of FT-2102 (Olutasidenib), a Potent Mutant-Selective IDH1 Inhibitor" Journal of Medicinal Chemistry 2020 63 (4), 1612-1623  DOI:10.1021/acs.jmedchem.9b01423

Zenon Konteatis, et al. "Vorasidenib (AG-881): A First-in-Class, Brain-Penetrant Dual Inhibitor of Mutant IDH1 and 2 for Treatment of Glioma" ACS Medicinal Chemistry Letters 2020 11 (2), 101-107
DOI: 10.1021/acsmedchemlett.9b00509

May 28 Suruchi Singh (Pancera/Stamatatos Lab) Ho et al. "Bottom-up structural proteomics: cryoEM of protein complexes enriched from the cellular milieu" Nature Methods 17: 79-85 (2020).                                               DOI: 10.1038/s41592-019-0637-y
June 11 Abigail Lambert (Stoddard Lab) Marcandalli et al. (2019) "Induction of Potent Neutralizing Antibody Responses by a Designed Protein Nanoparticle Vaccine for Respiratory Syncytial Virus” Cell 177: 1420 - 1431.                                                                                  doi: 10.1016/j.cell.2019.01.046.