Welcome to the Stamatatos Lab

The Stamatatos Lab, within the Vaccine and Infectious Disease Division of the Fred Hutchinson Cancer Research Center, focuses on developing immunization approaches to expand and guide the maturation of particular B cell lineages along specific evolutionary pathways that result in the production of protective antibodies against infectious agents. We employ a wide range of experimental approaches, including deep sequencing and bioinformatic analysis of B cell receptor repertoires, structure-based immunogen-design, immunological, molecular and cellular biology techniques, crystallography, and knock-in and transgenic animals. Our work includes the pre-clinical and clinical evaluation of candidate vaccines.