Welcome to the Stamatatos Lab
The Stamatatos group works towards the development of a safe and effective vaccine against HIV-1. Our major emphasis is the design of protein immunogens that would induce the production of neutralizing antibodies against diverse HIV-1 strains (commonly referred to as ‘broadly neutralizing antibodies’). Our immunogens target specific germline B cell receptors and induce the activation of the corresponding naïve B cells. Upon immunization we monitor the maturation of these B cell clonal lineages by employing bioinformatic tools and diverse immunological, molecular, and computational approaches. Our ultimate goal is to guide B cell maturation along specific evolutionary pathways.