Viral Infections in Stem Cell Transplant Patients

Viral infections are a major cause of mortality following stem cell transplantation. By measuring double-stranded DNA (dsDNA) virus kinetics in blood during the high-risk weeks immediately following myeloablative therapy, we demonstrated that multi-virus reactivation occurs frequently and persistently in patients during this period, and that cumulative dsDNA viral burden is associated with increased mortality.

Our goal is to determine whether novel antiviral therapies might improve outcomes for transplant recipients. We are also interested in performing similar studies for respiratory viruses, which are also a potentially lethal complication following transplantation.

Viral infections in stem cell transplant patients