SCHIFFER GROUP -- Publications


Human Microbiome

1. Mayer B, Srinivasan S, Fiedler T, Marrazzo J, Fredricks D, Schiffer JT. Rapid and profound shifts in the vaginal microbiota following antibiotic treatment for bacterial vaginosis. J Infect Dis. 2015, Feb 12. pii: jiv079. [Epub ahead of print] PMID: 25676470


Viral Transmission

2. Schiffer JT, Mayer B, Fong Y, Swan D, Wald A. Herpes Simplex Virus-2 transmission probability estimates based on quantity of viral shedding. J R Soc Interface. 2014 Mar 26;11(95):20140160. PMID: 24671939, PMCID: PMC4006256.


Shedding Dynamics

3. Melvin A, Mohan K, Schiffer JT, Drolette L, Magaret A, Corey L, Wald A. Plasma and Cerebrospinal Fluid herpes simplex virus levels at diagnosis and outcome of neonatal infection. J Pediatr. 2014, S0022-3476(14)01063-4. PMID: 25491092, PMCID: PMC4380781.
4.  Dhankani V, Kutz N, Schiffer JT. Herpes Simplex Virus-2 genital tract shedding is not predictable over months or years in infected persons. PLOS Comput Biol, 2014 Nov 6;10(11)e1003922. PMID: 25375183, PMCID: PMC4222642.
5. * Schiffer JT, Swan D, Al Sallaq R, Magaret A, Johnston C, Mark KE, Selke S, Obemichael N, Kuntz S, Zhu J, Robinson B, Huang ML, Jerome KR, Wald A & Corey L.  Rapid localized spread and immunologic containment of herpes simplex virus-2 in the human genital tract. eLife. 2013, Apr 16;2:e00288. PMID: 23606943, PMCID: PMC3629793.
6.  Schiffer JT, Corey L. Rapid host immune response and viral dynamics in herpes simplex virus-2 infection. Nat Med. 2013, 19(3)280-8. PMID: 23467247. PMCID: PMC3981536.
7.  Schiffer JT, Wald A, Selke S, Corey L, and Magaret A. The kinetics of mucosal herpes simplex virus-2 infection in humans: evidence for rapid viral-host interactions. JID. 2011, 204(4):554-61. PMID: 21791657, PMCID: PMC3144170.
8.   * Schiffer JT, Abu-Raddad L, Mark KE, Zhu J, Selke S, Magaret A, Wald A and Corey L.  Frequent release of low amounts of herpes simplex virus from neurons: results of a mathematical model. Science Translational Medicine. 2009, 1(7): 7ra16. PMID: 20161655, PMCID: PMC2818652.
9.   Schiffer JT, and Corey L.  New concepts in understanding genital herpes.  Curr Infect Dis Rep. 2009, 11(6):457-64. PMID: 19857385, PMCID: PMC2804398.



10.   Abu-Raddad L, Schiffer JT, Morrow RA, Alsallaq RA, Akala FA, Riedner G and Wilson D.  HSV-2 serology can be predictive of HIV epidemic potential and hidden sexual risk behavior in the Middle East and North Africa.  Epidemics. 2010, 2(4): 173-182. PMID: 21352788, PMCID: PMC3722433.
11.   Alsallaq RA, Schiffer JT, Longini IM, Wald A, Corey L, and Abu-Raddad L. Population level impact of an imperfect prophylactic HSV-2 vaccine.  Sex Trans Dis. 2010; 36(5):290-7. PMID: 20351622, PMCID: PMC2860045.


Antiviral Therapy

12.  Schiffer, JT, Swan D, Corey L, Wald A.  Rapid viral expansion and short drug half-life explain the incomplete effectiveness of current Herpes Simplex Virus-2 directed antiviral agents. Antimicrob Agents Chemother. 2013 Dec;57(12):5820-9. PMID: 24018260, PMCID: PMC3837890.
13.  Schouten JT, Schiffer JT.  Equal HIV-1 decay kinetics in HSV-2 infected and uninfected clinical trial participants treated with antiretroviral therapy.  JAIDS. 2012, 60(1): 68-71. PMID: 22330608, PMCID: PMC3331968.
14.  Johnston C, Saracino M, Kuntz S, Magaret A, Selke S, Huang ML, Schiffer JT, Koelle DM, Corey L and Wald A.  Ineffectiveness of daily standard and high-dose antiviral therapy in preventing short episodes of genital HSV-2 reactivation: three randomized, open-label cross-over trials. Lancet. 2012, Jan4, 379(9816):641-7. PMID: 22225814, PMCID: PMC3420069.
15.  * Schiffer JT, Magaret A, Selke S, Corey L, and Wald A.  Detailed analysis of mucosal herpes simplex virus-2 kinetics with and without antiviral therapy. J Antimicrob Chemotherapy. 2011, 66(11): 2593-600. PMID: 21865349, PMCID: PMC3191945.


Viral Immunology

16.  Schiffer JT. Mucosal HSV-2 specific CD8+ T-cells represent containment of prior viral shedding rather than a correlate of future protection. Front Immunol. 2013 Jul 29;4:209. PMID: 23908652, PMCID: PMC3725545.
17.  Jing L, Schiffer JT, Chong TM, Bruckner J, Davies DH, Felgner PL, Wald A, Haas J, Verjans GM and Koelle DM.  Specific memory CD4 T-cells are independent of viral persistence and show prolonged maintenance of subdominant specificities. J Virol. 2013, 87(5):2617-27. PMID: 23255792, PMCID: PMC3571405.
18.  Moss NJ, Magaret A, Laing K, Kask AS, Wang M, Mark K, Schiffer JT, Wald A, and Koelle D.  Peripheral blood CD4 T-cell and pDC reactivity to HSV-2 and pDC number do not correlate with the clinical or virologic severity of recurrent genital herpes. J Virol. 2012, 86(18):9952-63. PMID: 22761381, PMCID: PMC3446596.
19.  * Schiffer JT, Abu-Raddad L, Mark KE, Zhu J, Selke, S, Koelle, DM, Wald A and Corey L.  Mucosal host immune response predicts the severity and duration of herpes simplex virus-2 genital tract shedding episodes.  Proc Natl Acad Sci. 2010; 107(44): 18973-8. PMID: 20956313, PMCID: PMC2973882.


Viral Eradication

20. Weber N, Stone D, Sedlak R, De Silva Feelixge H, Roychoudhury P, Schiffer JT, Aubert M, Jerome K. AAV-mediated delivery of zinc finger nucleases targeting hepatitis B virus inhibits active replication. PLoS One. 2014 May 14;9(5):e97579. PMID: 24827459, PMCID: PMC4020843.
21.  Matrajt L, Younan P, Kiem HP, Schiffer JT. The majority of CD4+ T-cell depletion during acute SHIV89.6P infection occurs in uninfected cells. JVI. 2014 Mar;88(6):3202-12. PMID: 24390339. PMCID: PMC3957925.
22.  * Schiffer JT, Swan D, Stone D, Jerome K. Predictors of hepatitis B cure using gene therapy to deliver DNA cleavage enzymes: a mathematical modeling approach. PLoS Comp Bio. 2013 Jul;9(7):e1003131. PMID: 23861664, PMCID: PMC3701691.
23.  * Schiffer JT, Aubert M, Weber N, Mintzer E, Stone D, Jerome KR.  Targeted DNA mutagenesis for the cure of chronic viral infections. J Virol. 2012, 86(17):8920-36. PMID: 22718830, PMCID: PMC3416169.


Infections in Immunocompromised host

24.  Schiffer JT, Scott JT and Corey L.  A siege of hepatitis: fighting a defiant virus.  Nat Med. 2011, 17(3):253-4. PMID: 21383719.
25.  Schiffer JT, Leung J. Rotavirus infection and epidermal necrolysis of the bowel in a patient with AIDS.  BMJ Case Rep. 2009: bcr0920092255-bcr0920092255. PMCID: PMC22125583.
26.  Schiffer JT, Kirby K, Sandmaier B, Maloney D, Storb R, Corey L, and Boeckh M. Timing and severity of community acquired respiratory virus infections after myeloablative versus nonmyeloablative hematopoietic stem cell transplantation.  Haematologica. 2009:94(8):1101-1108. PMID: 19644142, PMCID: PMC2719033.
27.  Schiffer JT, Sterling TR. Timing of antiretroviral therapy initiation in tuberculosis patients with AIDS: a decision analysis. J Acquir Immune Defic Syndr. 2007;44:229–234. PMID: 17159657.
28.  Paulo RZ, Ding L, Hackman J, Reeves-Hammock L, Schiffer JT, Shintani A, Holland SM, Sterling TR. Decreased CD4+ lymphocytes and innate immune responses in adults with prior extrapulmonary tuberculosis. J Allergy Clin Immunol.  2006;117(4):916-23.



29.  Leung J, Schiffer JT. Fever and jaundice, (A case of Weil’s disease). Am J Med. 2009;122(2):129-31. PMID: 19185086.  
30.  Durand C, Schiffer JT. With jaundiced eyes (Sickle cell intrahepatic cholestasis). Am J Med. 2009;122(1):21-3. PMID: 19114165.
31.  Cho E, Schiffer JT, Murphy K, Smith BD. Isolated granulocytic sarcoma: case reports of 3 rare presentations and review. Clinical Leukemia. 2008, 2(4): 275.
32.  Bachmann JM, Brownlee N, Schiffer JT.  Multi-system mystery (A case of microscopic polyangiitis). Am J Med. 2008;121(5):387-9. PMID: 18456032.
33.  Schiffer JT, Jefferson BK. Cases from the Osler Medical Service at Johns Hopkins University: unilateral breast enlargement as a complication of a thrombosed AV fistula. Am J Med. 2003, 1;115(5):04-6. PMID: 14553878.
34.  Schiffer JT, Park C, Jefferson BK. Cases from the Osler Medical Service at Johns Hopkins University. Sister Mary Joseph nodule. Am J Med. 2003;114(1):68-70. PMID: 12638559.