SALAMA LAB -- Publications
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  • Gall A, Gaudet RG, Gray-Owen SD, Salama NR (Aug 2017). TIFA Signaling in Gastric Epithelial Cells Initiates the cag Type 4 Secretion System-Dependent Innate Immune Response to Helicobacter pylori Infection. MBio. doi: 10.1128/mBio.01168-17
  • Keilberg D, Zavros Y, Shepherd B, Salama NR, Ottemann KM. (Oct 2016). Spatial and Temporal Shifts in Bacterial Biogeography and Gland Occupation during the Development of a Chronic Infection. MBio. doi: 10.1128/mBio.01705-16
  • Elhenawy W, Davis RM, Fero J, Salama NR, Felman MF, Ruiz N. (Aug 2016). The O-Antigen Flippase Wzk Can Substitute for MurJ in Peptidoglycan Synthesis in Helicobacter pylori and Escherichia coli. PLOS ONE. doi: 10.1371/journal.pone.0161587
  • Yang DC, Blair KM, Salama NR. (Feb 2016). Staying in Shape: the Impact of Cell Shape on Bacterial Survival in Diverse Environments. Microbiol Mol Biol Rev. doi: 10.1128/MMBR.00031-15
  • Liu Y, Frirdich E, Taylor JA, Chan AC, Blair KM, Vermeulen J, Ha R, Murphy ME, Salama NR, Gaynor EC, Tanner ME. (Jan 2016). A Bacterial Cell Shape-Determining Inhibitor. ACS Chem Biol. doi: 10.1021/acschembio.5b01039
  • Talarico S, Safaeian M, Gonzalez P, Hildesheim A, Herrero R, Porras C, Cortes B, Larson A, Fang FC, Salama NR. (Dec 2015). Quantitative Detection and Genotyping of Helicobacter pylori from Stool using Droplet Digital PCR Reveals Variation in Bacterial Loads that Correlates with cagA Virulence Gene Carriage. Helicobacter. doi: 10.1111/hel.12289
  • Martinez LE, Hardcastle JM, Wang J, Pincus Z, Tsang J, Hoover TR, Bansil R, Salama NR (Sep 2015). Helicobacter pylori strains vary cell shape and flagellum number to maintain robust motility in viscous environments. Mol Microbiol. doi: 10.1111/mmi.13218
  • Gall A, Fero J, McCoy C, Claywell BC, Sanchez CA, Blount PL, Li X, Vaughan TL, Matsen FA, Reid BJ, Salama NR (Jun 2015). Bacterial composition of the human upper gastrointestinal tract microbiome is dynamic and associated with genomic instability in a Barrett's Esophagus cohort. PLOS ONE. 10 (6), e0129055
  • Liu H, Fero JB, Mendez M, Carpenter BM, Servetas SL, Rahman A, Goldman MD, Boren T, Salama NR, Merrell DS, Dubois A (May 2015). Analysis of a single Helicobacter pylori strain over a 10-year period in a primate model. Int J Med Microbiol. 305 (3), 392-403
  • Chan AC, Blair KM, Liu Y, Frirdich E, Gaynor EC, Tanner ME, Salama NR, Murphy ME (Feb 2014). Helical shape of Helicobacter pylori requires an atypical glutamine as a zinc ligand in the carboxypeptidase Csd4. J Biol Chem. 290 (6), 3622-38
  • Sycuro LK, Rule CS, Petersen TW, Wyckoff TJ, Sessler T, Nagarkar DB, Khalid F, Pincus Z, Biboy J, Vollmer W, Salama NR (Nov 2013). Flow-cytometry based enrichment of cell shape mutants identifies multiple genes that influence Helicobacter pylori morphology. Molecular Microbiology, 90 (4), 869-83
  • Salama NR, Hartung ML, Müller A (Jun 2013) Life in the human stomach: persistence strategies of the bacterial pathogen Helicobacter pylori. Nature Reviews Microbiology, 11 (6), 385-99
  • Dorer MS, Cohen IE, Sessler TH, Fero J, Salama NR (Jan 2013) Natural competence promotes Helicobacter pylori chronic infection., Infection and immunity, 81 (1), 209-15
  • Wyckoff TJ, Taylor JA, Salama NR (Nov 2012) Beyond growth: novel functions for bacterial cell wall hydrolases., Trends in microbiology20 (11), 540-7
  • Talarico S, Whitefield SE, Fero J, Haas R, Salama NR (Jun 2012) Regulation of Helicobacter pylori adherence by gene conversion., Molecular microbiology84 (6), 1050-61
  • Sycuro LK, Wyckoff TJ, Biboy J, Born P, Pincus Z, Vollmer W, Salama NR (Mar 2012) Multiple peptidoglycan modification networks modulate Helicobacter pylori's cell shape, motility, and colonization potential., PLoS pathogens8 (3), e1002603
  • Dorer MS, Sessler TH, Salama NR (2011) Recombination and DNA repair in Helicobacter pylori., Annual Review of Microbiology65, 329-48
  • Humbert O, Dorer MS, Salama NR (Jan 2011) Characterization of Helicobacter pylori factors that control transformation frequency and integration length during inter-strain DNA recombination., Molecular microbiology79 (2), 387-401
  • Dorer MS, Fero J, Salama NR (Jul 2010) DNA damage triggers genetic exchange in Helicobacter pylori., PLoS pathogens,6 (7) e1001026
  • Sycuro LK, Pincus Z, Gutierrez KD, Biboy J, Stern CA, Vollmer W, Salama NR (May 2010) Peptidoglycan crosslinking relaxation promotes Helicobacter pylori's helical shape and stomach colonization., Cell141 (5), 822-33
  • Pinto-Santini DM, Salama NR (Dec 2009) Cag3 is a novel essential component of the Helicobacter pylori Cag type IV secretion system outer membrane subcomplex., Journal of bacteriology191 (23), 7343-52
  • Lowenthal AC, Hill M, Sycuro LK, Mehmood K, Salama NR, Ottemann KM (Dec 2009) Functional analysis of the Helicobacter pylori flagellar switch proteins., Journal of bacteriology191 (23), 7147-56
  • Dorer MS, Talarico S, Salama NR (Oct 2009) Helicobacter pylori's unconventional role in health and disease., PLoS pathogens5 (10), e1000544
  • Talarico S, Gold BD, Fero J, Thompson DT, Guarner J, Czinn S, Salama NR (Jun 2009) Pediatric Helicobacter pylori isolates display distinct gene coding capacities and virulence gene marker profiles., Journal of clinical microbiology47 (6), 1680-8
  • Romo-González C, Salama NR, Burgeño-Ferreira J, Ponce-Castañeda V, Lazcano-Ponce E, Camorlinga-Ponce M, Torres J (May 2009) Differences in genome content among Helicobacter pylori isolates from patients with gastritis, duodenal ulcer, or gastric cancer reveal novel disease-associated genes., Infection and immunity77 (5), 2201-11
  • Amundsen SK, Fero J, Salama NR, Smith GR (Apr 2009) Dual nuclease and helicase activities of Helicobacter pylori AddAB are required for DNA repair, recombination, and mouse infectivity., The Journal of biological chemistry 284 (25), 16759-66 
  • Kraemer PS, Mitchell A, Pelletier MR, Gallagher LA, Wasnick M, Rohmer L, Brittnacher MJ, Manoil C, Skerett SJ, Salama NR (Jan 2009) Genome-wide screen in Francisella novicida for genes required for pulmonary and systemic infection in mice., Infection and immunity77 (1), 232-44
  • Baltrus DA, Amieva MR, Covacci A, Lowe TM, Merrell DS, Ottemann KM, Stein M, Salama NR, Guillemin K (Jan 2009) The complete genome sequence of Helicobacter pylori strain G27., Journal of bacteriology191 (1), 447-8
  • Humbert O, Salama NR (Dec 2008) The Helicobacter pylori HpyAXII restriction-modification system limits exogenous DNA uptake by targeting GTAC sites but shows asymmetric conservation of the DNA methyltransferase and restriction endonuclease components., Nucleic acids research36 (21), 6893-906 
  • Amundsen SK, Fero J, Hansen LM, Cromie GA, Solnick JV, Smith GR, Salama NR (Aug 2008) Helicobacter pylori AddAB helicase-nuclease and RecA promote recombination-related DNA repair and survival during stomach colonization.,Molecular microbiology69 (4), 994-1007
  • Salama NR, Gonzalez-Valencia G, Deatherage B, Aviles-Jimenez F, Atherton JC, Graham DY, Torres J (May 2007) Genetic analysis of Helicobacter pylori strain populations colonizing the stomach at different times postinfection.,Journal of bacteriology189 (10), 3834-45
  • Baldwin DN, Shepherd B, Kraemer P, Hall MK, Sycuro LK, Pinto-Santini DM, Salama NR (Feb 2007) Identification of Helicobacter pylori genes that contribute to stomach colonization., Infection and immunity75 (2), 1005-16
  • Baldwin DN, Salama NR (2007) Using genomic microarrays to study insertional/transposon mutant libraries., Methods in enzymology421, 90-110
  • Salama NR, Manoil C (Jun 2006) Seeking completeness in bacterial mutant hunts., Current opinion in microbiology9 (3), 307-11
  • Pinto-Santini D, Salama NR (Aug 2005) The biology of Helicobacter pylori infection, a major risk factor for gastric adenocarcinoma., Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology14 (8), 1853-8
  • Moore JM, Salama NR (Mar 2005) Mutational Analysis of Metronidazole Resistance in Helicobacter Pylori., Antimicrobial Agents and Chemotherapy49 (3), 1236-7
  • Salama NR, Shepherd B, Falkow S (Dec 2004) Global Transposon Mutagenesis and Essential Gene Analysis of Helicobacter Pylori., Journal of Bacteriology186 (23), 7926-35
  • Aviles-Jimenez F, Letley DP, Gonzalez-Valencia G, Salama N, Torres J, Atherton JC (Aug 2004) Evolution of the Helicobacter pylori vacuolating cytotoxin in a human stomach., Journal of Bacteriology186 (15), 5182-5
  • Thompson LJ, Danon SJ, Wilson JE, O'Rourke JL, Salama NR, Falkow S, Mitchell H, Lee A (Aug 2004) Chronic Helicobacter pylori infection with Sydney strain 1 and a newly identified mouse-adapted strain (Sydney strain 2000) in C57BL/6 and BALB/c mice., Infection and Immunity72 (8), 4668-79
  • Solnick JV, Hansen LM, Salama NR, Boonjakuakul JK, Syvanen M (2004) Modification of Helicobacter pylori outer membrane protein expression during experimental infection of rhesus macaques., Proceedings of the National Academy of Sciences of the United States of America101 (7), 2106-11
  • Bjorkholm B, Salama NR (2003) Genomics of helicobacter 2003., Helicobacter8 Suppl 1, 1-7
  • Guillemin K, Salama NR, Tompkins LS, Falkow S (Nov 2002) Cag pathogenicity island-specific responses of gastric epithelial cells to Helicobacter pylori infection., Proceedings of the National Academy of Sciences of the United States of America99 (23), 15136-41
  • Amieva MR, Salama NR, Tompkins LS, Falkow S (Oct 2002) Helicobacter pylori enter and survive within multivesicular vacuoles of epithelial cells., Cellular Microbiology4 (10), 677-90
  • Bjorkholm BM, Guruge JL, Oh JD, Syder AJ, Salama N, Guillemin K, Falkow S, Nilsson C, Falk PG, Engstrand L, Gordon JI (Sep 2002) Colonization of germ-free transgenic mice with genotyped Helicobacter pylori strains from a case-control study of gastric cancer reveals a correlation between host responses and HsdS components of type I restriction-modification systems., Journal of Biological Chemistry277 (37), 34191-7
  • Joyce EA, Chan K, Salama NR, Falkow S (Jun 2002) Redefining bacterial populations: a post-genomic reformation., Nature Reviews. Genetics3 (6), 462-73
  • Bjorkholm B, Lundin A, Sillen A, Guillemin K, Salama N, Rubio C, Gordon JI, Falk P, Engstrand L (Dec 2001) Comparison of genetic divergence and fitness between two subclones of Helicobacter pylori., Infection and Immunity69 (12), 7832-8
  • Israel DA, Salama N, Krishna U, Rieger UM, Atherton JC, Falkow S, Peek RM Jr (Dec 2001) Helicobacter pylori genetic diversity within the gastric niche of a single human host., Proceedings of the National Academy of Sciences of the United States of America98 (25), 14625-30
  • McDaniel TK, Dewalt KC, Salama NR, Falkow S (Mar 2001) New approaches for validation of lethal phenotypes and genetic reversion in Helicobacter pylori., Helicobacter6 (1), 15-23
  • Israel DA, Salama N, Arnold CN, Moss SF, Ando T, Wirth HP, Tham KT, Camorlinga M, Blaser MJ, Falkow S, Peek RM Jr (Mar 2001) Helicobacter pylori strain-specific differences in genetic content, identified by microarray, influence host inflammatory responses., Journal of Clinical Investigation107 (5), 611-20
  • Salama NR, Otto G, Tompkins L, Falkow S (Feb 2001) Vacuolating cytotoxin of Helicobacter pylori plays a role during colonization in a mouse model of infection., Infection and Immunity69 (2), 730-6
  • Salama N, Guillemin K, McDaniel TK, Sherlock G, Tompkins L, Falkow S (2000) A whole-genome microarray reveals genetic diversity among Helicobacter pylori strains., Proceedings of the National Academy of Sciences of the United States of America97 (26), 14668-73
  • Salama NR, Falkow S (Jul 1999) Genomic clues for defining bacterial pathogenicity., Microbes and Infection1 (8), 615-9
  • Salama NR, Chuang JS, Schekman RW (Feb 1997) Sec31 encodes an essential component of the COPII coat required for transport vesicle budding from the endoplasmic reticulum, Molecular Biology of the Cell8 (2), 205-17
  • Salama NR, Schekman RW (Aug 1995) The role of coat proteins in the biosynthesis of secretory proteins., Current Opinion in Cell Biology7 (4), 536-43
  • Barlowe C, Orci L, Yeung T, Hosobuchi M, Hamamoto S, Salama N, Rexach MF, Ravazzola M, Amherdt M, Schekman R (1994) COPII: a membrane coat formed by Sec proteins that drive vesicle budding from the endoplasmic reticulum., Cell77 (6), 895-907
  • Salama NR, Yeung T, Schekman RW (Nov 1993) The Sec13p complex and reconstitution of vesicle budding from the ER with purified cytosolic proteins., EMBO Journal12 (11), 4073-82
  • Pryer NK, Salama NR, Schekman R, Kaiser CA (Feb 1993) Cytosolic Sec13p complex is required for vesicle formation from the endoplasmic reticulum in vitro., Journal of Cell Biology120 (4), 865-75