A hallmark of many diseases and cancers is a dysfunctional cytoskeleton. A properly functioning cytoskeleton is needed for a wide variety of cellular events ranging from cell shape to cell signaling and migration/metastasis. We use multidisciplinary approaches to study these dynamic structural elements in various processes including wound repair and nuclear architecture/organization. Our goal is to understand the role of these elements in regulating normal developmental events and how this regulation goes awry in diseases/cancers, thereby providing new avenues for possible therapeutic targets or to enhance the effectiveness of existing treatment modalities.
Our current research efforts are divided among studies of: (1) Molecular and cellular mechanisms of single cell and multicellular (tissue) wound repair; (2) Actin and microtubule cytoskeleton dynamics mediated by the Rho1 small GTPase and its effectors Wash, Capu, and Spire; and (3) Nuclear architecture and organization.