OLSON LAB

2015

Toledo CM, Ding Y, Hoellerbauer P, Davis RJ, Basom R, Girard EJ, Lee E, Corrin P, Hart T, Bolouri H, Davison J, Zhang Q, Hardcastle J, Aronow BJ, Plaisier CL, Baliga NS, Moffat J, Lin Q, Li XN, Nam DH, Lee J, Pollard SM, Zhu J, Delrow JJ, Clurman BE, Olson JM, Paddison PJ. Genome-wide CRISPR-Cas9 Screens Reveal Loss of Redundancy between PKMYT1 and WEE1 in Glioblastoma Stem-like Cells. Cell Rep. 2015 Dec 22;13(11):2425-39

Moreno-Gonzalez A, Olson JM, Klinghoffer RA. Predicting responses to chemotherapy in the context that matters-the patient. Molecular and Cellular Oncology. 2015 June 10.

Hoffman L, Fouladi M, Olson JM, Daryani VM, Stewart CF, Wetmore C, Kocak M, Onar-Thomas A, Wagner L, Gururangan S, Packer R, Blaney S, Gajjar A, Kun LE, Boyett JM, Gilbertson JR. Phase I Trial of Weekly MK-0752 in Children with Refractory Central Nervous System Malignancies: A Pediatric Brain Tumor Consortium Study. Childs Nerv Syst. 2015 May 1

Parrish-Novak, J, Holland EC, Olson JM.  2015.  Image-Guided Tumor Resection.. Cancer journal (Sudbury, Mass.). 21(3):206-12. Abstract

Klinghoffer, RA, Bahrami BS, Hatton BA, Frazier JP, Moreno-Gonzalez A, Strand AD, Kerwin WS, Casalini JR, Thirstrup DJ, You S et al..  2015.  A technology platform to assess multiple cancer agents simultaneously within a patient's tumor.. Science translational medicine. 7(284):284ra58. Abstract

Herman JA, Toledo CM, Olson JM, DeLuca JG, Paddison PJ. Molecular pathways: regulation and targeting of kinetochore-microtubule attachment in cancer. Clin Cancer Res. 2015 Jan 15;21(2):233-9

2014

Sipione, S, Rigamonti D, Valenza M, Zuccato C, Conti L, Pritchard J, Kooperberg C, Olson JM, Cattaneo E.  2014.  Early transcriptional profiles in huntingtin-inducible striatal cells by microarray analyses.. Human molecular genetics.

Morfouace, M, Shelat A, Jacus M, Freeman BB, Turner D, Robinson S, Zindy F, Wang Y-D, Finkelstein D, Ayrault O et al..  2014.  Pemetrexed and Gemcitabine as Combination Therapy for the Treatment of Group3 Medulloblastoma.. Cancer cell. Abstract

Olson, JM.  2014.  Therapeutic opportunities for medulloblastoma come of age.. Cancer cell. 25(3):267-9. Abstract

Shih, DJH, Northcott PA, Remke M, Korshunov A, Ramaswamy V, Kool M, Luu B, Yao Y, Wang X, Dubuc AM et al..  2014.  Cytogenetic Prognostication Within Medulloblastoma Subgroups.. Journal of clinical oncology : official journal of the American Society of Clinical Oncology. Abstract

Toledo, CM, Herman JA, Olsen JB, Ding Y, Corrin P, Girard EJ, Olson JM, Emili A, Deluca JG, Paddison PJ.  2014.  BuGZ Is Required for Bub3 Stability, Bub1 Kinetochore Function, and Chromosome Alignment.. Developmental cell. 28(3):282-94. Abstract

Kumar, A, Boyle EA, Tokita M, Mikheev AM, Sanger MC, Girard E, Silber JR, Gonzalez-Cuyar LF, Hiatt JB, Adey A et al..  2014.  Deep sequencing of multiple regions of glial tumors reveals spatial heterogeneity for mutations in clinically relevant genes.. Genome biology. 15(12):530. Abstract

2013

Dey, J, Dubuc AM, Pedro KD, Thirstrup D, Mecham B, Northcott PA, Wu X, Shih D, Tapscott SJ, LeBlanc M et al..  2013.  MyoD Is a Tumor Suppressor Gene in Medulloblastoma.. Cancer research. Abstract

Gottardo, NG, Hansford JR, McGlade JP, Alvaro F, Ashley DM, Bailey S, Baker DL, Bourdeaut F, Cho Y-J, Clay M et al..  2013.  Medulloblastoma Down Under 2013: a report from the third annual meeting of the International Medulloblastoma Working Group.. Acta neuropathologica. Abstract

Hubert, CG, Bradley RK, Ding Y, Toledo CM, Herman J, Skutt-Kakaria K, Girard EJ, Davison J, Berndt J, Corrin P et al..  2013.  Genome-wide RNAi screens in human brain tumor isolates reveal a novel viability requirement for PHF5A.. Genes & development. 27(9):1032-45. Abstract

Aref, D, Moffatt CJ, Agnihotri S, Ramaswamy V, Dubuc AM, Northcott PA, Taylor MD, Perry A, Olson JM, Eberhart CG et al..  2013.  Canonical TGF-β Pathway Activity Is a Predictor of SHH-Driven Medulloblastoma Survival and Delineates Putative Precursors in Cerebellar Development.. Brain pathology (Zurich, Switzerland). 23(2):178-91. Abstract

Diede, SJ, Yao Z, Keyes CC, Tyler AE, Dey J, Hackett CS, Elsaesser K, Kemp CJ, Neiman PE, Weiss WA et al..  2013.  Fundamental differences in promoter CpG island DNA hypermethylation between human cancer and genetically engineered mouse models of cancer.. Epigenetics : official journal of the DNA Methylation Society. 8(12):1254-60. Abstract

Hatton, BA, Ellison DW, Gajjar A, Kool M, Fero M, Olson JM.  2013.  Prognostic value and functional consequences of cell cycle inhibitor p27Kip1 loss in medulloblastoma.. Biomarker research. 1(1):14. Abstract

Lee, SJ, Lindsey S, Graves B, Yoo S, Olson JM, Langhans SA.  2013.  Sonic hedgehog-induced histone deacetylase activation is required for cerebellar granule precursor hyperplasia in medulloblastoma.. PloS one. 8(8):e71455. Abstract

• Ding, Y, Hubert CG, Herman J, Corrin P, Toledo CM, Skutt-Kakaria K, Vazquez J, Basom R, Zhang B, Risler JK et al..  2012.  Cancer-specific requirement for BUB1B/BubR1 in human brain tumor isolates and genetically transformed cells.. Cancer discovery.
  
• Lee, MJ, Hatton BA, Villavicencio EH, Khanna PC, Friedman SD, Ditzler S, Pullar B, Robison K, White KF, Tunkey C et al..  2012.  Hedgehog pathway inhibitor saridegib (IPI-926) increases lifespan in a mouse medulloblastoma model.. Proceedings of the National Academy of Sciences of the United States of America. 109(20):7859-64.
• Leary, SES, Olson JM.  2012.  The molecular classification of medulloblastoma: driving the next generation clinical trials.. Current opinion in pediatrics. 24(1):33-9.
• Dey, J, Ditzler S, Knoblaugh SE, Hatton BA, Schelter JM, Cleary MA, Mecham B, Rorke-Adams LB, Olson JM.  2012.  Distinct Smoothened mutation causes severe cerebellar developmental defects and medulloblastoma in a novel transgenic mouse model.. Molecular and cellular biology.
  
• Northcott, PA, Shih DJH, Peacock J, Garzia L, Morrissy SA, Zichner T, Stütz AM, Korshunov A, Reimand J, Schumacher SE et al..  2012.  Subgroup-specific structural variation across 1,000 medulloblastoma genomes.. Nature. 488(7409):49-56.

• Stroud, MR, Hansen, SJ, Olson, JM.  In Vivo Bio-imaging Using Chlorotoxin-based Conjugates. Curr Pharm Dec. 2011 Dec;17(38):4362-71. PMID: 22204434
• Leary SE, Olson, JM. The molecular classification of medulloblastoma: driving the next generation clinical trials. Curr Opin Pediatr. 2011 Dec 20. [Epub ahead of print]. PMID: 22189395
• Paugh BS, Broniscer A, Qu C, Miller CP, Zhang J, Tatevossian RG, Olson JM, Geyer JR, Chi SN, da Silva NS, Onar-Thomas A, Baker JN, Gajjar A, Ellison DW, Baker SJ. Genome-wide analyses identify recurrent amplifications of receptor tyrosine kinases and cell-cycle regulatory genes in diffuse intrinsic pontine glioma. J Clin Oncol. 2011 Oct 20;29(30):3999-4006. Epub 2011 Sep 19.PMID: 21931021
• Fouladi M, Stewart CF, Olson J, Wagner LM, Onar-Thomas A, Kocak M, Packer RJ, Goldman S, Gururangan S, Gajjar A, Demuth T, Kun LE, Boyett JM, Gilbertson RJ. Phase I trial of MK-0752 in children with refractory CNS malignancies: a pediatric brain tumor consortium study. J Clin Oncol. 2011 Sep 10;29(26):3529-34. Epub 2011 Aug 8. PMID: 21825264
• Lee S.J., Krauthauser C., Maduskuie V., Fawcett P.T., Olson J.M., Rajasekaran S.A.  Curcumin-induced HDAC inhibition and attenuation of medulloblastoma growth in vitro and in vivo.  BMC Cancer. 2011 Apr 18;11:144. PMID: 21501498
• Cho YJ, Tsherniak A, Tamayo P, Santagata S, Ligon A, Greulich H, Berhoukim R, Amani V, Goumnerova L, Eberhart CG, Lau CC, Olson JM, Gilbertson RJ, Gajjar A, Delattre O, Kool M, Ligon K, Meyerson M, Mesirov JP, Pomeroy SL. Integrative genomic analysis of medulloblastoma identifies a molecular subgroup that drives poor clinical outcome. J Clin Oncol. 2011 Apr 10;29(11):1424-30. Epub 2010 Nov 22. PMID: 21098324
• Wu C, Hansen SJ, Hou Q, Yu J, Zeigler M, Jin Y, Burnham DR, McNeill JD, Olson JM, Chiu DT. Design of highly emissive polymer dot bioconjugates for in vivo tumor targeting. Angew Chem Int Ed Engl. 2011 Apr 4;50(15):3430-4. doi: 10.1002/anie.201007461. Epub 2011 Mar 4. PMID: 21381164
• Cherry T.J., Wang S., Bormuth I., Schwab M., Olson J., Cepko C.L. NeuroD factors regulate cell fate and neurite stratification in the developing retina. J Neurosci. 2011 May 18;31(20):7365-79. PMID: 21593321
• Akcan M., Stroud M.R., Hansen S.J., Clark R.J., Daly N.L., Craik D.J., Olson J.M.  Chemical re-engineering of chlorotoxin improves bioconjugation properties for tumor imaging and targeted therapy. J Med Chem. 2011 Jan 6. [Epub ahead of print].

• Giussani C, Poliakov A, Ferri RT, Plawner LL, Browd SR, Shaw DW, Filardi TZ, Hoeppner C, Geyer JR, Olson JM, Douglas JG, Villavicencio EH, Ellenbogen RG, Ojemann JG. DTI fiber tracking to differentiate demyelinating diseases from diffuse brain stem glioma. Neuroimage. 2010 Aug 1;52(1):217-23. Epub 2010 Apr 2. PMID: 20363335
• Lee M. J.-E., Veiseh O., Bhattarai N., Sun C., Hansen S.J., Ditzler S., Knoblaugh S., Lee D., Ellenbogen R., Zhang M., Olson J.M.  Rapid pharmacokinetic and biodistribution studies using chlorotoxin-conjugated iron oxide nanoparticles: A novel non-radioactive method. PLoS ONE 5(3): e9536, 2010. PMCID: PMC2832013.
• Benn C.L., Luthi-Carter R., Kuhn A., Sadri-Vakili G., Blankson K.L., Dalai S.C., Goldstein D.L., Spires T.L., Pritchard
  J., Olson, J.M., van Dellen A., Hannan A.H., Cha J.-H.  Environmental enrichment reduces neuronal intranuclear inclusion load but has no effect on messenger RNA expression in a mouse model of Huntington disease. Journal of Neuropathology and Experimental Neurology 69(8):817-827, 2010.
• Ravanpay A.C., Hansen S.J., Olson J.M.  Transcriptional inhibition of REST by NeuroD2 during neuronal differentiation.  Molecular and Cellular Neuroscience 44(2):178-189, 2010. PMCID: PMC2866295 [Available on 2011/6/1].
• Hatton B.A., Villavicencio E.H., Pritchard J., LeBlanc M., Hansen S., Ulrich M., Ditzler S., Pullar B., Stroud M.R., Olson J.M.  Notch signaling is not essential in sonic hedgehog-activated medulloblastoma. Oncogene 29(26):3865-3872, 2010. PMCID: PMC2896441.
• Lee M.J., Veiseh O., Bhattarai N., Sun C., Hansen S.J., Ditzler S., Knoblaugh S., Lee D., Ellenbogen R., Zhang M., Olson J.M.  Rapid pharmacokinetic and biodistribution studies using chlorotoxin-conjugated iron oxide nanoparticles: a novel non-radioactive method. PLoS ONE 5(3): e9536, 2010. PMCID: PMC2832013.

• Veiseh, O., Sun, C., Fang, C.,  Bhattarai, N.,  Gunn, J.,  Kievit, F., Du, K., Pullar, B., Lee, D.,  Ellenbogen, R.G., Olson, J., Zhang, M.  Specific targeting of brain tumors with an optical/magnetic resonance imaging nanoprobe across the blood-brain barrier.  Cancer Res 69:(15), 2009. PMCID: PMC2742601.
• Diede, S.J., Guenthoer, J., Geng, L.N., Mahoney, S.E., Marotta, M., Olson, J.M., Tanaka, H., Tapscott, S.J.  DNA methylation of developmental genes in pediatric medulloblastomas identified by denaturation analysis of methylation differences. Proc Natl Acad Sci U S A. 2010 Jan 5;107(1):234-9. Epub 2009 Dec 4. PMID: 19966297
• Kievit F.M., Veiseh O., Bhattarai N., Fang C., Gunn J.W., Lee D., Ellenbogen R.G., Olson J.M., Zhang M.  PEI-PEG-Chitosan Copolymer Coated Iron Oxid Nanoparticles for Safe Gene Delivery: synthesis, complexation, and transfection.  Adv Funct Mater 19(14):2244-2251, 2009. PMCID: PMC2756666. 

• Sun, C., Fang, C., Stephen, Z., Veiseh, O., Hansen, S., Lee, D., Ellenbogen, R.G., Olson, J., Zhang, M.  Tumor-targeted drug delivery and MRI contrast enhancement by chlorotoxin-conjugated iron oxide nanoparticles.  Nanomedicine 3(4):495-505, 2008.  PMCID: PMC2890026.
• Ravanpay, A., Olson, J.M.  E protein dosage influences brain development more than family member identity.  Journal of Neuroscience Research 86(7):1472-1481, 2008.
• Spiller, S.E., Ditzler, S.H. Pullar, B.J., Olson, J.M.  Response of preclinical medulloblastoma models to combination therapy with 13-cis retinoic acid and suberoylanilide hydroxamic acid (SAHA).  Journal of Neuro-Oncology 87(2):133-141, 2008.
• Hatton, B.A., Villavicencio, E.H., Tsuchiya, K.D., Pritchard, J.I., Ditzler, S., Pullar, B., Hansen, S., Knoblaugh, S.E., Lee, D., Eberhart, C.G., Hallahan, A.R., Olson, J.M.  The Smo/Smo model: Hedgehog-induced medulloblastoma with 90% incidence and leptomeningeal spread.  Cancer Research 68(6): 1768-76, 2008. 
• Sun, C., Veiseh, O., Gunn, J., Fang, C., Hansen, S., Lee, D., Sze, R., Ellenbogen, J., Olson, J., Zhang, M.  In vivo MRI detection of gliomas by chlorotoxin-conjugated superparamagnetic nanoprobes.  Small 4(3):372-379, 2008. PMCID: PMC2692358.
• Pritchard, J.I., Olson, J.M.  Methylation of PTCH1, the Patched-1 gene, in a panel of primary medulloblastomas.  Cancer Genetics and Cytogenetics 180(1):47-50, 2008. PMCID: PMC2219922.

• Strand, A.D., Aragaki, A.K., Baquet, Z.C., Hodges, A., Cunningham, P., Holmans, P., Jones, K.R., Jones, L., Kooperberg, C., Olson, J.M. Conservation of regional gene expression in mouse and human brain. PLoS Genet. 3(4):e59, 2007. Full Text
• Kaltenbach, L.S., Romero, E., Becklin, R.R., Chettier, R., Bell, R., Phansalkar, A., Strand, A., Torcassi, C., Savage, J., Hurlburt, A., Cha, G.H., Ukani, L., Chepanoske, C.L., Zhen, Y., Sahasrabudhe, S., Olson, J., Kurschner, C., Ellerby, L.M., Peltier, J.M., Botas, J., Hughes, R.E. Huntingtin interacting proteins are genetic modifiers of neurodegeneration. PLoS Genet. 3(5):e82, 2007. Full Text
• Veiseh, M., Gabikian, P., Bahrami, S.-B., Veiseh, O., Zhang, M., Hackman, R.C., Ravanpay, A.C., Stroud, M.R., Kusuma, Y., Hansen, S.J., Kwok, D., Muñoz, N.M., Sze, R.W., Grady, W.M., Greenberg, N.M., Ellenbogen, R.G., Olson, J.M. Tumor paint: a chlorotoxin:Cy5.5 bioconjugate for intra-operative visualization of cancer foci. Cancer Research 67(14):6882-88, 2007. PMID: 17638899. Full Text
• Kuhn, A., Goldstein, D.R., Hodges, A., Strand, A.D., Sengstag, T., Kooperberg, C., Becanovic, K., Pouladi, M.A., Sathasivam, K., Cha, J.-H. J., Hannan, A.J., Hayden, M.R., Leavitt, B.R., Dunnett, S.B., Ferrante, R.J., Albin, R., Shelbourne, P., Delorenzi, M., Augood, S.J., Faull, R.L.M., Olson, J.M., Bates, G.P., Jones, L., Luthi-Carter, R. Mutant huntingtin’s effects on striatal gene expression in mice recapitulate changes observed in human Huntington’s disease brain and do not differ with mutant huntingtin length or wild-type huntingtin dosage. Human Molecular Genetics 16(15):1845-61, 2007. Full Text
• Strand A.D., Baquet Z.C., Aragaki, A.K., Holmans, P., Yang, L., Cleren, C., Beal, M.F., Jones, L., Kooperberg, C., Olson, J.M., Jones, K.R. Microarray profiling of animal models supports a link between BDNF loss and Huntington's disease.Journal of Neuroscience, 27(43): 11758-68, 2007
• Strand, A.D., Baquet, Z.C., Aragaki, A.K., Holmans, P., Yang, L., Cleren, C., Beal, M.F., Jones, L., Kopperberg, C., Olson, J.M., Jones, K.R. Expression Profiling of Huntington's disease models suggests that brain-derived neurotrophic factor depletion plays a major role in striatal degeneration. J Neuosci, 27(43):11758-68, 2007.

• Douglas, J.G., Rockhill, J.K., Olson, J.M., Ellenbogen, R.G., Geyer, J.R. Cisplatin-based chemotherapy followed by focal, reduced-dose irradiation for pediatric primary central nervous system germinomas. Journal of Pediatric Hematology 28(1):36-39, 2006. Full Text
• Apostol BL, Illes K, Pallos J, Bodai L, Wu J, Strand A, Schweitzer ES, Olson JM, Kazantsev A, Marsh JL, Thompson LM. Mutant huntingtin alters MAPK signaling pathways in PC12 and striatal cells: ERK1/2 protects against mutant huntingtin-associated toxicity. Human Molecular Genetics 15(2):273-285, 2006. Full Text
• Hodges, A., Strand, A.D., Aragaki, A.K., Kuhn, A., Sengstag, T., Hughes, G., Elliston, L.A., Hartog, C., Goldstein, D.R., Thu, D., Hollingsworth, Z.R., Collin, F., Synek, B., Holmans, P.A., Young, A.B., Wexler, N.S., Delorenzi, M., Kooperberg, C., Augood, S.J., Faull, R.L, Olson, J.M., Jones, L., Luthi-Carter, R. Regional and cellular gene expression changes in human Huntington's disease brain. Human Molecular Genetics 15(6):965-977, 2006. Full Text
• Ince-Dunn, G., Hall, B.J., Hu, S.C., Ripley, B., Huganir, R.L., Olson, J.M., Tapscott, S.J.,Ghosh, A. Regulation of thalamocortical patterning and synaptic maturation by neuroD2. Neuron 49(5):683-695, 2006. Full Text
• Spiller, S.E., Ravanpay, A.C., Hahn, A.W., Olson, J.M. Suberoylanilide hydroxamic acid is effective in preclinical studies of medulloblastoma. Journal of Neuro-Oncology 79(3):259-70, 2006. PMID: 16645722. Full Text
• Lin, C.-H., Tapscott, S.J., Olson, J.M. Congenital hypothyroidism (cretinism) in neuroD2-deficient mice. Molecular and Cellular Biology 26(11):4311-5, 2006 PMID: 16705180. Full Text
• Jones, L., Goldstein, D.R., Hughes, G., Strand, A.D., Collin, F., Dunnett, S.B., Kooperberg, C., Aragaki, A., Olson, J.M., Augood, S.J., Faull, R.L.M., Luthi-Carter, R., Moskvina, V., Hodges, A.K. Assessment of the relationship between pre-chip and post-chip quality measures for Affymetrix GeneChip expression data. BMC Bioinformatics 19(7):211, 2006. Full Text
• Fan, W., Khalid, N., Hallahan, A.R., Olson, J.M., Zhao, L.P. A statistical method for predicting splice variants between two groups of samples using GeneChip expression array data. Theor Biol Med Model 3:19, 2006. PMID: 16603076. Full Text
• Strand, A.D., Aragaki, A.K., Baquet, Z.C., Hodges, A., Cunningham, P., Holmans, P., Jones, K.R., Jones, L., Kooperberg, C., Olson, J.M. Regional and cellular gene expression changes in human Huntington's disease brain. Human Molecular Genetics 15(6):965-77, 2006. Full Text
• Hatton, B.A., Pritchard, J.I., Olson, J.M. Nervous system cancer models: medulloblastoma. Drug Discovery Today: Disease Models 3(2): 167-74, 2006.
• Hatton, B.A., Knoepfler. P.S., Kenney, A.M., Rowitch, D.H., de Alborán, I.M., Olson, J.M., Eisenman, R.N. N-myc is an essential downstream effector of Shh signaling during both normal and neoplastic cerebellar growth. Cancer Research 66(17):8655-61, 2006. PMID: 16951180. Full Text

• Lin, C.-H., Hansen, S., Wang, Z., Storm, D.R., Tapscott, S.J., Olson, J.M. The dosage of the neuroD2 transcription factor regulates amygdala development and emotional learning. Proceedings of the National Academy of Sciences 102(41): 14877-14882, 2005. PMID: 16203979. Full Text 
• Veiseh, O., Sun, C., Gunn, J., Kohler, N., Gabikian, P., Lee, D., Bhattarai, N., Ellenbogen, R., Sze, R., Hallahan, A., Olson, J., Zhang, M. An optical and MRI multifunctional nanoprobe for targeting gliomas. Nano Letters 5(6): 1003-1008, 2005. PMID: 15943433. 
• Strand, A.D., Aragaki, A.K., Shaw, D., Bird, T., Holton, J., Turner, C., Tapscott, S.J., Tabrizi, S.J., Schapira, A.H., Kooperberg, C., Olson, J.M. Gene expression in Huntington’s disease skeletal muscle: a potential biomarker. Human Molecular Genetics 14(13):1863-1876, 2005. Full Text | Abstract
• Kooperberg, C., Aragaki, A., Strand, A.D., Olson, J.M. Significance testing for small microarray experiments. Statistics in Medicine 24:2281-2298, 2005. Full Text
• Fan, W., Pritchard, J.I., Olson, J.M., Khalid, N., and Zhao, L.P. A class of models for analyzing GeneChip® gene expression analysis array data. BMC Genomics 6:16, 2005. PMID: 15710039. Full Text | Abstract
• Valenza, M., Rigamonti, D., Goffredo, D., Zuccato, C., Fenu, S., Jamot, L., Strand, A., Tarditi, A., Woodman, B., Racchi, M., Mariotti, C., DiDonato, S., Corsini, A., Bates, G., Pruss, R., Olson, J.M., Sipione, S., Tartari, M., Cattaneo, E. Dysfunction of the cholesterol biosynthetic pathway in Huntington's Disease. Journal of Neuroscience 25(43):9932-9939, 2005. Full Text
• Benn, C.L., Landles, C., Li, H., Strand, A.D., Woodman, B., Sathasivam, K., Li, S.H., Ghazi-Noori, S., Hockly, E., Faruque, S.M., Cha, J.H., Sharpe, P.T., Olson, J.M., Li, X.J., Bates, G. Contribution of nuclear and extranuclear polyQ to neurological phenotypes in mouse models of Huntington’s disease. Human Molecular Genetics 14(20): 3065-3078, 2005. Full Text

• Hallahan, A.R., Pritchard, J.I., Hansen, S., Benson, M., Stoeck, J., Hatton, B.A., Russell, T.L., Bernstein, I.D., Beachy, P.A., Olson, J.M. The SmoA1 mouse model reveals that Notch signaling is critical for the growth and survival of Sonic Hedgehog-induced medulloblastomas. Cancer Research 64:7794-7800, 2004. PMID: 15520185. Full Text | Abstract
• Olson, J.M. and Hallahan, A.R. P38 MAP Kinase: a convergence point in cancer therapy. Trends in Molecular Medicine 10(3):125-129, 2004. PMID: 15102355. Full Text | Abstract
• Lin, C.H., Stoeck, J., Ravanpay, A.C., Guillemot, F., Tapscott, S.J., and Olson, J.M. Regulation of neuroD2 expression in mouse brain. Developmental Biology 265(1):234-245, 2004. PMID: 14697366. Full Text | Abstract

• Hallahan, A.R., Pritchard, J.I., Chandraratna, R.A., Ellenbogen, R., Geyer, J.R., Overland, R.P., Strand, A.D., Tapscott, S.J., and Olson, J.M. BMP- 2 mediates retinoid-induced apoptosis in medulloblastoma cells through a paracrine effect. Nature Medicine 9(8):1033-1038, 2003. PMID: 12872164. Full Text | Abstract 
• Gilbertson, R.J., Hill, D.A., Hernan, R., Kocak, M., Geyer, R., Olson, J., Gajjar, A, Rush, L., Hamilton, R.L., Finkelstein, S.D., and Pollack, I.F. ERBB1 is amplified and overexpressed in high-grade diffusely infiltrative pediatric brain stem glioma. Clinical Cancer Research 9(10 Pt1): 3620-3624, 2003. Full Text
• Ditzler, S., Stoeck, J., LeBlanc, M., Kooperberg, C., Hansen, S., Coppin, L., Olson, J.M. A rapid neurobehavioral assessment reveals that FK506 delays symptom onset in R6/2 Huntington’s disease mice. PreClinica 1(3):115-126, 2003.  Abstract

• Berman, D.M., Karhadkar, S.S., Hallahan, A.R., Pritchard, J.I., Eberhart, C.G., Watkins, D.N., Chen, J.K., Cooper, M.K., Taipale, J., Olson, J.M., and Beachy, P.A.Medulloblastoma growth inhibition by hedgehog pathway blockade. Science 297:1559-1561, 2002. PMID: 12202832. Full Text | Abstract
• Kooperberg, C., Sipione, S., LeBlanc, M., Strand, A.D., Cattaneo, E., Olson, J.M. Evaluating test statistics to select interesting genes in microarray experiments. Human Molecular Genetics 11(19):2223-2232, 2002. Full Text
• Strand, A.D., Olson, J.M., Kooperberg, C. Estimating the statistical significance of gene expression changes observed with oligonucleotide arrays. Human Molecular Genetics 11(19): 2207-2221, 2002. Full Text | Abstract
• Xu, X.L., Olson, J.M., Zhao, L.P. A regression based method to identify differentially expressed genes in microarray time course studies and its application in an inducible Huntington’s disease transgenic model. Human Molecular Genetics 11(17):1977-1985, 2002. Full Text | Abstract
• Lieberman, A.P., Harmison, G., Strand, A.D., Olson, J.M., Fischbeck, K.H. Altered androgen receptor function due to polyglutamine expansion. Human Molecular Genetics 11(17):1967-1976, 2002.  Abstract
• Sipione, S., Rigamonti, D., Valenza, M., Zuccato, C., Conti, L., Pritchard, J., Kooperberg, C., Olson, J.M., Cattaneo, E. Early transcriptional profiles in huntingtin-inducible striatal cells by microarray analyses. Human Molecular Genetics 11(17):1953-1965, 2002. Full Text | PDF | Abstract
• Chan, E.Y.W., Luthi-Carter, R., Strand, A., Solano, S.M., Hanson, S.A., DeJohn, M.M., Kooperberg, C., Chase, K.O., DiFiglia, M., Young, A.B., Leavitt, B.R., Cha, J.-H.J., Aronin, N., Hayden, M.R., Olson, J.M. Increased huntingtin protein length reduces the severity of polyglutamine-induced gene expression changes in mouse models of Huntington disease. Human Molecular Genetics 11(17):1939-1951, 2002. Full Text | Abstract
• Luthi-Carter, R., Strand, A.D., Hanson, S.A., Kooperberg, C., Schilling, G., LaSpada, A.R., Merry, D.E., Young, A.B., Ross, C.A., Borchelt, D.R., Olson, J.M. Polyglutamine and transcription: gene expression changes shared by DRPLA and Huntington’s disease mouse models reveal context-independent effects. Human Molecular Genetics 11(17):1927-1937, 2002. Full Text | Abstract
• Luthi-Carter R., Hanson S.A., Strand A.D., Bergstrom D.A., Chun W., Peters N.L., Woods A.M., Chan E.Y., Kooperberg C., Krainc D., Young A.B., Tapscott S.J., Olson J.M. Dysregulation of gene expression in the R6/2 model of polyglutamine disease: parallel changes in muscle and brain. Hum Mol Genet 11(17): 1911-26, 2002. Full Text | Abstract
• Pomeroy S.L., Tamayo P., Gaasenbeek M., Sturla L.M., Angelo M., McLaughlin M.E., Kim J.Y., Goumnerova L.C., Black P.M., Lau C., Allen J.C., Zagzag D., Olson J.M., Curran T., Wetmore C., Biegel J.A., Poggio T., Mukherjee S., Rifkin R., Califano A., Stolovitzky G., Louis D.N., Mesirov J.P., Lander E.S., Golub T.R. Prediction of central nervous system embryonal tumour outcome based on gene expression. Nature 415(6870):436-42, 2002. Full Text | Abstract
• Strand, A.D., Olson, J.M., Kooperberg, C. Estimating the statistical significance of gene expression changes observed with oligonucleotide arrays.  Hum Mol Genet. 11(19):2207-21, 2002.  Full Text

• Hughes R.E., Lo R.S., Davis C., Strand A.D., Neal C.L., Olson J.M., Fields S. Altered transcription in yeast expressing expanded polyglutamine. Proc. Natl. Acad. Sci. USA. Nov 6;98(23):13201-6, 2001. Full Text | Abstract
• Kiehl, T.-K., Olson, J.M., and Pulst, S.-M. The Hereditary Disease Array Group (HDAG) - Microarrays, Models and Mechanisms: A Collaboration Update. Current Genomics 2:221-229, 2001.

• J.G., Olson J.M., Tapscott S.J., Zhao L.P.. An efficient and robust statistical modeling approach to discover differentially expressed genes using genomic expression profiles. Genome Res 11(7): 1227-36, 2001. Full Text | Abstract
• Olson J.M., Asakura A., Snider L., Hawkes R., Strand A., Stoeck J., Hallahan A., Pritchard J., Tapscott S.J. NeuroD2 is necessary for development and survival of central nervous system neurons. Dev Biol 234(1): 174-87, 2001. PMID: 11356028. Full Text | Abstract
• Hughes R.E., Olson J.M. Therapeutic opportunities in polyglutamine disease. Nature Med 7(4): 419-23, 2001. Full Text | Abstract
• Johnston, D.L., Benjamin, D.R., and Olson, J.M. Gastrointestinal Stromal Tumor in a Patient with Previous Neuroblastoma. J. Ped. Hem. Oncol. 23:255-256, 2001.

• Luthi-Carter R., Strand A., Peters N.L., Solano S.M., Hollingsworth Z.R., Menon A.S., Frey A.S., Spektor B.S., Penney E.B., Schilling G., Ross C.A., Borchelt D.R., Tapscott S.J., Young A.B., Cha J.H., Olson J.M.. Decreased expression of striatal signaling genes in a mouse model of Huntington's disease. Hum Mol Genet 9(9): 1259-71, 2000. Full Text | Abstract
• Farah M.H., Olson J.M., Sucic H.B., Hume R.I., Tapscott S.J., Turner D.L. Generation of neurons by transient expression of neural bHLH proteins in mammalian cells. Development 127(4): 693-702, 2000. Full Text | Abstract | PDF