2018

Correnti CE, Gewe MM, Mehlin C, Bandaranayake AD, Johnsen, WA, Rupert PB, Brusniak M, Clarke M, Burke SE, de van der Schueren W, Pilat K, Turnbaugh SM, May D, Watson A, Chan MK, Bahl, CD, Olson JM, Strong RK. Multiscale biosynthetic production and global structure-based classification of cystine-dense peptides. Nat Struct Mol Biol 2018 Mar;25(3):270-278.

Correnti CE, Laszlo GS, de van der Schueren W, Godwin CD, Bandaranayake AD, Busch MA, Gudgeon CJ, Bates OM, Olson JM, Mehlin C, Walter RB. Simultaneous multiple interaction T-cell engaging (SMITE) bispecific antibodies overcome bispecific T-cell engager (BiTE) resistance via CD28 co-stimulation. Leukemia 2018 Jan;32:1239–43.

Brabetz S, Leary SES, Gröbner SN, Nakamoto MW, Şeker-Cin H, Girard EJ, Cole B, Strand AD, Bloom KL, Hovestadt V, Mack NL, Schwalm B, Korshunov A, Balasubramanian GP, Northcott PA, Pedro K, Dey J, Hansen S, Ditzler S, Lichter P, Chavez L, Jones DTW, Koster J, Pfister SM, Kool M, Olson JM. A biobank of patient-derived pediatric brain tumor models. Nat Med 2018 (In Press).

Hwang EI, Kool M, Burger PC, Capper D, Chavez L, Brabetz S, Williams-Hughes C, Billups C, Heier L, Jaju A, Michalski J, Li Y, Leary S, Zhou T, von Deimling A, Jones DTW, Fouladi M, Pollack IF, Gajjar A, Packer RJ, Pfister SM, Olson JM. Extensive Molecular and Clinical Heterogeneity in Histologically Diagnosed CNS-PNET Patients Treated as a Single Entity: A Report from the Children’s Oncology Group Randomized ACNS0332 Trial. Jour Clin Onc 2018 (In Press).

2017

Xu T, Zhang H, Park SS, Venneti S, Kuick R, Ha K, Michael LE, Santi M, Uchida C, Uchida T, Srinivasan A, Olson JM, Dlugosz AA, Camelo-Piragua S, Rual JF. Loss of Pin1 suppresses Hedgehog-driven medulloblastoma tumorigenesis. Neoplasia. 2017 Mar;19(3):216-225.

Parrish-Novak J, Byrnes-Blake K, Lalayeva N, Burleson S, Fidel J, Gilmore R, Gayheart-Walsten P, Bricker GA, Crumb WJ Jr, Tarlo KS, Hansen S, Wiss V, Malta E, Dernell WS, Olson JM, Miller DM. Nonclinical Profile of BLZ-100, a Tumor-Targeting Fluorescent Imaging Agent. Int J Toxicol. 2017 Mar/Apr;36(2):104-112.

Frazier JP, Bertout JA, Kerwin WS, Moreno-Gonzalez A, Casalini JR, Grenley MO, Beirne E, Watts KL, Keener A, Thirstrup DJ, Tretyak I, Ditzler SH, Tripp CD, Choy K, Gillings S, Breit MN, Meleo KA, Rizzo V, Herrera CL, Perry JA, Amaravadi RK, Olson JM, Klinghoffer RA. Multidrug Analyses in Patients Distinguish Efficacious Cancer Agents Based on Both Tumor Cell Killing and Immunomodulation. Cancer Res. 2017 Jun;77(11):2869-2880.

Ding Y, Herman JA, Toledo CM, Lang JM, Corrin P, Girard EJ, Basom R, Delrow JJ, Olson JM, Paddison PJ. ZNF131 suppresses centrosome fragmentation in glioblastoma stem-like cells through regulation of HAUS5. Oncotarget. 2017 Jul 25;8(30):48545-48562.

Cavalli FMG, Remke M, Rampasek L, Peacock J, Shih DJH, Luu B, Garzia L, Torchia J, Nor C, Morrissy AS, Agnihotri S, Thompson YY, Kuzan-Fischer CM, Farooq H, Isaev K, Daniels C, Cho BK, Kim SK, Wang KC, Lee JY, Grajkowska WA, Perek-Polnik M, Vasiljevic A, Faure-Conter C, Jouvet A, Giannini C, Nageswara Rao AA, Li KKW, Ng HK, Eberhart CG, Pollack IF, Hamilton RL, Gillespie GY, Olson JM, Leary S, Weiss WA, Lach B, Chambless LB, Thompson RC, Cooper MK, Vibhakar R, Hauser P, van Veelen MC, Kros JM, French PJ, Ra YS, Kumabe T, LÌ_pez-Aguilar E, Zitterbart K, Sterba J, Finocchiaro G, Massimino M, Van Meir EG, Osuka S, Shofuda T, Klekner A, Zollo M, Leonard JR, Rubin JB, Jabado N, Albrecht S, Mora J, Van Meter TE, Jung S, Moore AS, Hallahan AR, Chan JA, Tirapelli DPC, Carlotti CG, Fouladi M, Pimentel J, Faria CC, Saad AG, Massimi L, Liau LM, Wheeler H, Nakamura H, Elbabaa SK, Perezpena-Diazconti M, Chico Ponce de Leon F, Robinson S, Zapotocky M, Lassaletta A, Huang A, Hawkins CE, Tabori U, Bouffet E, Bartels U, Dirks PB, Rutka JT, Bader GD, Reimand J, Goldenberg A, Ramaswamy V, Taylor MD. Intertumoral Heterogeneity within Medulloblastoma Subgroups. Cancer Cell. 2017 Jun 12;31(6):737-754.

Cook Sangar ML, Genovesi LA, Nakamoto MW, Davis MJ, Knobluagh SE, Ji P, Millar A, Wainwright BJ, Olson JM. Inhibition of CDK4/6 by Palbociclib Significantly Extends Survival in Medulloblastoma Patient-Derived Xenograft Mouse Models. Clin Cancer Res. 2017 Jun 21; 23(19):5802-13.

Meehan TF, Conte N, Goldstein T, Inghirami G, Murakami MA, Brabetz S, Gu Z, Wiser JA, Dunn P, Begley DA, Krupke DM, Bertotti A, Bruna A, Brush MH, Byrne AT, Caldas C, Christie AL, Clark DA, Dowst H, Dry JR, Doroshow JH, Duchamp O, Evrard YA, Ferretti S, Frese KK, Goodwin NC, Greenawalt D, Haendel MA, Hermans E, Houghton PJ, Jonkers J, Kemper K, Khor TO, Lewis MT, Kent Lloyd KC, Mason J, Medico E, Neuhauser SB, Olson JM, Peeper DS, Rueda OM, Seong JK, Trusolino L, Vinolo E, Wechsler-Reya RJ, Weinstock DM, Welm A, Weroha SJ, Amant F, Pfister SM, Kool M, Parkinson H, Butte AJ, Bult CJ. PDX-MI: Minimal Information for Patient-Derived Tumor Xenograft Models. Cancer Res. 2017 Nov;77(21):e62–66.

Crook ZR, Sevilla GP, Friend D, Brusniak M, Bandaranayake AD, Clarke M, Gewe M, Mhyre AJ, Baker D, Strong RK, Bradley P, Olson JM. Mammalian Display Screening of Diverse Cystine-Dense Peptides for Difficult to Drug Targets. Nat Comm. 2017 Dec;8:2244.

2016

Rosenthal EL, Warram JM, de Boer E, Basilion JP, Biel MA, Bogyo M, Bouvet M, Brigman BE, Colson YL, DeMeester SR, Gurtner GC, Ishizawa T, Jacobs PM, Keereweer S, Liao JC, Nguyen QT, Olson JM, Paulsen KD, Rieves D, Sumer BD, Tweedle MF, Vahrmeijer AL, Weichert JP, Wilson BC, Zenn MR, Zinn KR, van Dam GM. Successful Translation of Fluorescence Navigation During Oncologic Surgery: A Consensus Report. J Nucl Med. 2016 Jan;57(1):144-50.

Bhardawaj G, Mulligan VK, Bahl CD, Gilmore JM, Harvey PJ, Cheneval O, Buchko GW, Pulavarti SVSRK, Kaas Q, Eletsky A, Huang P-S,  Johnsen WA, Greisen P, Rocklin GJ, Song Y, Linsky TW, Watkins A, Rettie SA, Xu X, Carter LP, Bonneau R, Olson JM, Coutsias E, Correnti C, Szyperski T, Craik DJ, Baker D. Accurate de novo design of hyperstable constrained peptides. Nature. 2016 Oct;538:329-35.

Pei Y, Liu KW, Wang J, Garancher A, Tao R, Esparza LA, Maier DL, Udaka YT, Murad N, Morrissy S, Seker-Cin H, Brabetz S, Qi L, Kogiso M, Schubert S, Olson JM, Cho YJ, Li XN, Crawford JR, Levy ML, Kool M, Pfister SM, Taylor MD, Wechsler-Reya RJ. HDAC and PI3K Antagonists Cooperate to Inhibit Growth of MYC-Driven Medulloblastoma. Cancer Cell. 2016 Mar 14;29(3):311-23.

Baik FM, Hansen S, Knoblaugh SE, Sahetya D, Mitchell RM, Xu C, Olson JM, Parrish-Novak J, Méndez E. Fluorescence Identification of Head and Neck Squamous Cell Carcinoma and High-Risk Oral Dysplasia With BLZ-100, a Chlorotoxin-Indocyanine Green Conjugate. JAMA Otolaryngol Head Neck Surg. 2016 Apr;142(4):330-8.

Ramaswamy V, Hielscher T, Mack SC, Lassaletta A, Lin T, Pajtler KW, Jones DT, Luu B, Cavalli FM, Aldape K, Remke M, Mynarek M, Rutkowski S, Gururangan S, McLendon RE, Lipp ES, Dunham C, Hukin J, Eisenstat DD, Fulton D, van Landeghem FK, Santi M, van Veelen ML, Van Meir EG, Osuka S, Fan X, Muraszko KM, Tirapelli DP, Oba-Shinjo SM, Marie SK, Carlotti CG, Lee JY, Rao AA, Giannini C, Faria CC, Nunes S, Mora J, Hamilton RL, Hauser P, Jabado N, Petrecca K, Jung S, Massimi L, Zollo M, Cinalli G, Bognár L, Klekner A, Hortobágyi T, Leary S, Ermoian RP, Olson JM, Leonard JR, Gardner C, Grajkowska WA, Chambless LB, Cain J, Eberhart CG, Ahsan S, Massimino M, Giangaspero F, Buttarelli FR, Packer RJ, Emery L, Yong WH, Soto H, Liau LM, Everson R, Grossbach A, Shalaby T, Grotzer M, Karajannis MA, Zagzag D, Wheeler H, von Hoff K, Alonso MM, Tuñon T, Schüller U, Zitterbart K, Sterba J, Chan JA, Guzman M, Elbabaa SK, Colman H, Dhall G, Fisher PG, Fouladi M, Gajjar A, Goldman S, Hwang E, Kool M, Ladha H, Vera-Bolanos E, Wani K, Lieberman F, Mikkelsen T, Omuro AM, Pollack IF, Prados M, Robins HI, Soffietti R, Wu J, Metellus P, Tabori U, Bartels U, Bouffet E, Hawkins CE, Rutka JT, Dirks P, Pfister SM, Merchant TE, Gilbert MR, Armstrong TS, Korshunov A, Ellison DW, Taylor MD. Therapeutic Impact of Cytoreductive Surgery and Irradiation of Posterior Fossa Ependymoma in the Molecular Era: A Retrospective Multicohort Analysis. J Clin Oncol. 2016 Jul 20;34(21):2468-77.

2015

Toledo CM, Ding Y, Hoellerbauer P, Davis RJ, Basom R, Girard EJ, Lee E, Corrin P, Hart T, Bolouri H, Davison J, Zhang Q, Hardcastle J, Aronow BJ, Plaisier CL, Baliga NS, Moffat J, Lin Q, Li XN, Nam DH, Lee J, Pollard SM, Zhu J, Delrow JJ, Clurman BE, Olson JM, Paddison PJ. Genome-wide CRISPR-Cas9 Screens Reveal Loss of Redundancy between PKMYT1 and WEE1 in Glioblastoma Stem-like Cells. Cell Rep. 2015 Dec 22;13(11):2425-39

Moreno-Gonzalez A, Olson JM, Klinghoffer RA. Predicting responses to chemotherapy in the context that matters-the patient. Molecular and Cellular Oncology. 2015 June 10.

Hoffman L, Fouladi M, Olson JM, Daryani VM, Stewart CF, Wetmore C, Kocak M, Onar-Thomas A, Wagner L, Gururangan S, Packer R, Blaney S, Gajjar A, Kun LE, Boyett JM, Gilbertson JR. Phase I Trial of Weekly MK-0752 in Children with Refractory Central Nervous System Malignancies: A Pediatric Brain Tumor Consortium Study. Childs Nerv Syst. 2015 May 1

Parrish-Novak, J, Holland EC, Olson JM.  2015.  Image-Guided Tumor Resection.. Cancer journal (Sudbury, Mass.). 21(3):206-12. Abstract

Klinghoffer, RA, Bahrami BS, Hatton BA, Frazier JP, Moreno-Gonzalez A, Strand AD, Kerwin WS, Casalini JR, Thirstrup DJ, You S et al..  2015.  A technology platform to assess multiple cancer agents simultaneously within a patient's tumor.. Science translational medicine. 7(284):284ra58. Abstract

Herman JA, Toledo CM, Olson JM, DeLuca JG, Paddison PJ. Molecular pathways: regulation and targeting of kinetochore-microtubule attachment in cancer. Clin Cancer Res. 2015 Jan 15;21(2):233-9

2014

Sipione, S, Rigamonti D, Valenza M, Zuccato C, Conti L, Pritchard J, Kooperberg C, Olson JM, Cattaneo E.  2014.  Early transcriptional profiles in huntingtin-inducible striatal cells by microarray analyses.. Human molecular genetics.

Morfouace, M, Shelat A, Jacus M, Freeman BB, Turner D, Robinson S, Zindy F, Wang Y-D, Finkelstein D, Ayrault O et al..  2014.  Pemetrexed and Gemcitabine as Combination Therapy for the Treatment of Group3 Medulloblastoma.. Cancer cell. Abstract

Olson, JM.  2014.  Therapeutic opportunities for medulloblastoma come of age.. Cancer cell. 25(3):267-9. Abstract

Shih, DJH, Northcott PA, Remke M, Korshunov A, Ramaswamy V, Kool M, Luu B, Yao Y, Wang X, Dubuc AM et al..  2014.  Cytogenetic Prognostication Within Medulloblastoma Subgroups.. Journal of clinical oncology : official journal of the American Society of Clinical Oncology. Abstract

Toledo, CM, Herman JA, Olsen JB, Ding Y, Corrin P, Girard EJ, Olson JM, Emili A, Deluca JG, Paddison PJ.  2014.  BuGZ Is Required for Bub3 Stability, Bub1 Kinetochore Function, and Chromosome Alignment.. Developmental cell. 28(3):282-94. Abstract

Kumar, A, Boyle EA, Tokita M, Mikheev AM, Sanger MC, Girard E, Silber JR, Gonzalez-Cuyar LF, Hiatt JB, Adey A et al..  2014.  Deep sequencing of multiple regions of glial tumors reveals spatial heterogeneity for mutations in clinically relevant genes.. Genome biology. 15(12):530. Abstract

2013

Dey, J, Dubuc AM, Pedro KD, Thirstrup D, Mecham B, Northcott PA, Wu X, Shih D, Tapscott SJ, LeBlanc M et al..  2013.  MyoD Is a Tumor Suppressor Gene in Medulloblastoma.. Cancer research. Abstract

Gottardo, NG, Hansford JR, McGlade JP, Alvaro F, Ashley DM, Bailey S, Baker DL, Bourdeaut F, Cho Y-J, Clay M et al..  2013.  Medulloblastoma Down Under 2013: a report from the third annual meeting of the International Medulloblastoma Working Group.. Acta neuropathologica. Abstract

Hubert, CG, Bradley RK, Ding Y, Toledo CM, Herman J, Skutt-Kakaria K, Girard EJ, Davison J, Berndt J, Corrin P et al..  2013.  Genome-wide RNAi screens in human brain tumor isolates reveal a novel viability requirement for PHF5A.. Genes & development. 27(9):1032-45. Abstract

Aref, D, Moffatt CJ, Agnihotri S, Ramaswamy V, Dubuc AM, Northcott PA, Taylor MD, Perry A, Olson JM, Eberhart CG et al..  2013.  Canonical TGF-β Pathway Activity Is a Predictor of SHH-Driven Medulloblastoma Survival and Delineates Putative Precursors in Cerebellar Development.. Brain pathology (Zurich, Switzerland). 23(2):178-91. Abstract

Diede, SJ, Yao Z, Keyes CC, Tyler AE, Dey J, Hackett CS, Elsaesser K, Kemp CJ, Neiman PE, Weiss WA et al..  2013.  Fundamental differences in promoter CpG island DNA hypermethylation between human cancer and genetically engineered mouse models of cancer. Epigenetics : official journal of the DNA Methylation Society. 8(12):1254-60. Abstract

Hatton, BA, Ellison DW, Gajjar A, Kool M, Fero M, Olson JM.  2013.  Prognostic value and functional consequences of cell cycle inhibitor p27Kip1 loss in medulloblastoma. Biomarker research. 1(1):14. Abstract

Lee, SJ, Lindsey S, Graves B, Yoo S, Olson JM, Langhans SA.  2013.  Sonic hedgehog-induced histone deacetylase activation is required for cerebellar granule precursor hyperplasia in medulloblastoma. PloS one. 8(8):e71455. Abstract

2012

Ding, Y, Hubert CG, Herman J, Corrin P, Toledo CM, Skutt-Kakaria K, Vazquez J, Basom R, Zhang B, Risler JK et al..  2012.  Cancer-specific requirement for BUB1B/BubR1 in human brain tumor isolates and genetically transformed cells.. Cancer discovery.

Lee, MJ, Hatton BA, Villavicencio EH, Khanna PC, Friedman SD, Ditzler S, Pullar B, Robison K, White KF, Tunkey C et al..  2012.  Hedgehog pathway inhibitor saridegib (IPI-926) increases lifespan in a mouse medulloblastoma model.. Proceedings of the National Academy of Sciences of the United States of America. 109(20):7859-64.

Leary, SES, Olson JM.  2012.  The molecular classification of medulloblastoma: driving the next generation clinical trials.. Current opinion in pediatrics. 24(1):33-9.

Dey, J, Ditzler S, Knoblaugh SE, Hatton BA, Schelter JM, Cleary MA, Mecham B, Rorke-Adams LB, Olson JM.  2012.  Distinct Smoothened mutation causes severe cerebellar developmental defects and medulloblastoma in a novel transgenic mouse model.. Molecular and cellular biology.

Northcott, PA, Shih DJH, Peacock J, Garzia L, Morrissy SA, Zichner T, Stütz AM, Korshunov A, Reimand J, Schumacher SE et al..  2012.  Subgroup-specific structural variation across 1,000 medulloblastoma genomes. Nature. 488(7409):49-56.

2011

Stroud, MR, Hansen, SJ, Olson, JM.  In Vivo Bio-imaging Using Chlorotoxin-based Conjugates. Curr Pharm Dec. 2011 Dec;17(38):4362-71. PMID: 22204434

Leary SE, Olson, JM. The molecular classification of medulloblastoma: driving the next generation clinical trials. Curr Opin Pediatr. 2011 Dec 20. [Epub ahead of print]. PMID: 22189395

Paugh BS, Broniscer A, Qu C, Miller CP, Zhang J, Tatevossian RG, Olson JM, Geyer JR, Chi SN, da Silva NS, Onar-Thomas A, Baker JN, Gajjar A, Ellison DW, Baker SJ. Genome-wide analyses identify recurrent amplifications of receptor tyrosine kinases and cell-cycle regulatory genes in diffuse intrinsic pontine glioma. J Clin Oncol. 2011 Oct 20;29(30):3999-4006. Epub 2011 Sep 19.PMID: 21931021

Fouladi M, Stewart CF, Olson J, Wagner LM, Onar-Thomas A, Kocak M, Packer RJ, Goldman S, Gururangan S, Gajjar A, Demuth T, Kun LE, Boyett JM, Gilbertson RJ. Phase I trial of MK-0752 in children with refractory CNS malignancies: a pediatric brain tumor consortium study. J Clin Oncol. 2011 Sep 10;29(26):3529-34. Epub 2011 Aug 8. PMID: 21825264

Lee S.J., Krauthauser C., Maduskuie V., Fawcett P.T., Olson J.M., Rajasekaran S.A.  Curcumin-induced HDAC inhibition and attenuation of medulloblastoma growth in vitro and in vivo.  BMC Cancer. 2011 Apr 18;11:144. PMID: 21501498

Cho YJ, Tsherniak A, Tamayo P, Santagata S, Ligon A, Greulich H, Berhoukim R, Amani V, Goumnerova L, Eberhart CG, Lau CC, Olson JM, Gilbertson RJ, Gajjar A, Delattre O, Kool M, Ligon K, Meyerson M, Mesirov JP, Pomeroy SL. Integrative genomic analysis of medulloblastoma identifies a molecular subgroup that drives poor clinical outcome. J Clin Oncol. 2011 Apr 10;29(11):1424-30. Epub 2010 Nov 22. PMID: 21098324

Wu C, Hansen SJ, Hou Q, Yu J, Zeigler M, Jin Y, Burnham DR, McNeill JD, Olson JM, Chiu DT. Design of highly emissive polymer dot bioconjugates for in vivo tumor targeting. Angew Chem Int Ed Engl. 2011 Apr 4;50(15):3430-4. doi: 10.1002/anie.201007461. Epub 2011 Mar 4. PMID: 21381164

Cherry T.J., Wang S., Bormuth I., Schwab M., Olson J., Cepko C.L. NeuroD factors regulate cell fate and neurite stratification in the developing retina. J Neurosci. 2011 May 18;31(20):7365-79. PMID: 21593321

Akcan M., Stroud M.R., Hansen S.J., Clark R.J., Daly N.L., Craik D.J., Olson J.M.  Chemical re-engineering of chlorotoxin improves bioconjugation properties for tumor imaging and targeted therapy. J Med Chem. 2011 Jan 6. [Epub ahead of print].

2010

Giussani C, Poliakov A, Ferri RT, Plawner LL, Browd SR, Shaw DW, Filardi TZ, Hoeppner C, Geyer JR, Olson JM, Douglas JG, Villavicencio EH, Ellenbogen RG, Ojemann JG. DTI fiber tracking to differentiate demyelinating diseases from diffuse brain stem glioma. Neuroimage. 2010 Aug 1;52(1):217-23. Epub 2010 Apr 2. PMID: 20363335

Lee M. J.-E., Veiseh O., Bhattarai N., Sun C., Hansen S.J., Ditzler S., Knoblaugh S., Lee D., Ellenbogen R., Zhang M., Olson J.M.  Rapid pharmacokinetic and biodistribution studies using chlorotoxin-conjugated iron oxide nanoparticles: A novel non-radioactive method. PLoS ONE 5(3): e9536, 2010. PMCID: PMC2832013.

Benn C.L., Luthi-Carter R., Kuhn A., Sadri-Vakili G., Blankson K.L., Dalai S.C., Goldstein D.L., Spires T.L., Pritchard
J., Olson, J.M., van Dellen A., Hannan A.H., Cha J.-H.  Environmental enrichment reduces neuronal intranuclear inclusion load but has no effect on messenger RNA expression in a mouse model of Huntington disease. Journal of Neuropathology and Experimental Neurology 69(8):817-827, 2010.

Ravanpay A.C., Hansen S.J., Olson J.M.  Transcriptional inhibition of REST by NeuroD2 during neuronal differentiation.  Molecular and Cellular Neuroscience 44(2):178-189, 2010. PMCID: PMC2866295 [Available on 2011/6/1].

Hatton B.A., Villavicencio E.H., Pritchard J., LeBlanc M., Hansen S., Ulrich M., Ditzler S., Pullar B., Stroud M.R., Olson J.M.  Notch signaling is not essential in sonic hedgehog-activated medulloblastoma. Oncogene 29(26):3865-3872, 2010. PMCID: PMC2896441.

Lee M.J., Veiseh O., Bhattarai N., Sun C., Hansen S.J., Ditzler S., Knoblaugh S., Lee D., Ellenbogen R., Zhang M., Olson J.M.  Rapid pharmacokinetic and biodistribution studies using chlorotoxin-conjugated iron oxide nanoparticles: a novel non-radioactive method. PLoS ONE 5(3): e9536, 2010. PMCID: PMC2832013.

2009

Veiseh, O., Sun, C., Fang, C.,  Bhattarai, N.,  Gunn, J.,  Kievit, F., Du, K., Pullar, B., Lee, D.,  Ellenbogen, R.G., Olson, J., Zhang, M.  Specific targeting of brain tumors with an optical/magnetic resonance imaging nanoprobe across the blood-brain barrier.  Cancer Res 69:(15), 2009. PMCID: PMC2742601.

Diede, S.J., Guenthoer, J., Geng, L.N., Mahoney, S.E., Marotta, M., Olson, J.M., Tanaka, H., Tapscott, S.J.  DNA methylation of developmental genes in pediatric medulloblastomas identified by denaturation analysis of methylation differences. Proc Natl Acad Sci U S A. 2010 Jan 5;107(1):234-9. Epub 2009 Dec 4. PMID: 19966297

Kievit F.M., Veiseh O., Bhattarai N., Fang C., Gunn J.W., Lee D., Ellenbogen R.G., Olson J.M., Zhang M.  PEI-PEG-Chitosan Copolymer Coated Iron Oxid Nanoparticles for Safe Gene Delivery: synthesis, complexation, and transfection.  Adv Funct Mater 19(14):2244-2251, 2009. PMCID: PMC2756666. 

2008

Sun, C., Fang, C., Stephen, Z., Veiseh, O., Hansen, S., Lee, D., Ellenbogen, R.G., Olson, J., Zhang, M.  Tumor-targeted drug delivery and MRI contrast enhancement by chlorotoxin-conjugated iron oxide nanoparticles.  Nanomedicine 3(4):495-505, 2008.  PMCID: PMC2890026.

Ravanpay, A., Olson, J.M.  E protein dosage influences brain development more than family member identity.  Journal of Neuroscience Research 86(7):1472-1481, 2008.

Spiller, S.E., Ditzler, S.H. Pullar, B.J., Olson, J.M.  Response of preclinical medulloblastoma models to combination therapy with 13-cis retinoic acid and suberoylanilide hydroxamic acid (SAHA).  Journal of Neuro-Oncology 87(2):133-141, 2008.

Hatton, B.A., Villavicencio, E.H., Tsuchiya, K.D., Pritchard, J.I., Ditzler, S., Pullar, B., Hansen, S., Knoblaugh, S.E., Lee, D., Eberhart, C.G., Hallahan, A.R., Olson, J.M.  The Smo/Smo model: Hedgehog-induced medulloblastoma with 90% incidence and leptomeningeal spread.  Cancer Research 68(6): 1768-76, 2008. 

Sun, C., Veiseh, O., Gunn, J., Fang, C., Hansen, S., Lee, D., Sze, R., Ellenbogen, J., Olson, J., Zhang, M.  In vivo MRI detection of gliomas by chlorotoxin-conjugated superparamagnetic nanoprobes.  Small 4(3):372-379, 2008. PMCID: PMC2692358.

Pritchard, J.I., Olson, J.M.  Methylation of PTCH1, the Patched-1 gene, in a panel of primary medulloblastomas.  Cancer Genetics and Cytogenetics 180(1):47-50, 2008. PMCID: PMC2219922.

2007

Strand, A.D., Aragaki, A.K., Baquet, Z.C., Hodges, A., Cunningham, P., Holmans, P., Jones, K.R., Jones, L., Kooperberg, C., Olson, J.M. Conservation of regional gene expression in mouse and human brain. PLoS Genet. 3(4):e59, 2007. Full Text

Kaltenbach, L.S., Romero, E., Becklin, R.R., Chettier, R., Bell, R., Phansalkar, A., Strand, A., Torcassi, C., Savage, J., Hurlburt, A., Cha, G.H., Ukani, L., Chepanoske, C.L., Zhen, Y., Sahasrabudhe, S., Olson, J., Kurschner, C., Ellerby, L.M., Peltier, J.M., Botas, J., Hughes, R.E. Huntingtin interacting proteins are genetic modifiers of neurodegeneration. PLoS Genet. 3(5):e82, 2007. Full Text

Veiseh, M., Gabikian, P., Bahrami, S.-B., Veiseh, O., Zhang, M., Hackman, R.C., Ravanpay, A.C., Stroud, M.R., Kusuma, Y., Hansen, S.J., Kwok, D., Muñoz, N.M., Sze, R.W., Grady, W.M., Greenberg, N.M., Ellenbogen, R.G., Olson, J.M. Tumor paint: a chlorotoxin:Cy5.5 bioconjugate for intra-operative visualization of cancer foci. Cancer Research 67(14):6882-88, 2007. PMID: 17638899. Full Text

Kuhn, A., Goldstein, D.R., Hodges, A., Strand, A.D., Sengstag, T., Kooperberg, C., Becanovic, K., Pouladi, M.A., Sathasivam, K., Cha, J.-H. J., Hannan, A.J., Hayden, M.R., Leavitt, B.R., Dunnett, S.B., Ferrante, R.J., Albin, R., Shelbourne, P., Delorenzi, M., Augood, S.J., Faull, R.L.M., Olson, J.M., Bates, G.P., Jones, L., Luthi-Carter, R. Mutant huntingtin’s effects on striatal gene expression in mice recapitulate changes observed in human Huntington’s disease brain and do not differ with mutant huntingtin length or wild-type huntingtin dosage. Human Molecular Genetics 16(15):1845-61, 2007. Full Text

Strand A.D., Baquet Z.C., Aragaki, A.K., Holmans, P., Yang, L., Cleren, C., Beal, M.F., Jones, L., Kooperberg, C., Olson, J.M., Jones, K.R. Microarray profiling of animal models supports a link between BDNF loss and Huntington's disease.Journal of Neuroscience, 27(43): 11758-68, 2007

Strand, A.D., Baquet, Z.C., Aragaki, A.K., Holmans, P., Yang, L., Cleren, C., Beal, M.F., Jones, L., Kopperberg, C., Olson, J.M., Jones, K.R. Expression Profiling of Huntington's disease models suggests that brain-derived neurotrophic factor depletion plays a major role in striatal degeneration. J Neuosci, 27(43):11758-68, 2007.

2006

Douglas, J.G., Rockhill, J.K., Olson, J.M., Ellenbogen, R.G., Geyer, J.R. Cisplatin-based chemotherapy followed by focal, reduced-dose irradiation for pediatric primary central nervous system germinomas. Journal of Pediatric Hematology 28(1):36-39, 2006. Full Text

Apostol BL, Illes K, Pallos J, Bodai L, Wu J, Strand A, Schweitzer ES, Olson JM, Kazantsev A, Marsh JL, Thompson LM. Mutant huntingtin alters MAPK signaling pathways in PC12 and striatal cells: ERK1/2 protects against mutant huntingtin-associated toxicity. Human Molecular Genetics 15(2):273-285, 2006. Full Text

Hodges, A., Strand, A.D., Aragaki, A.K., Kuhn, A., Sengstag, T., Hughes, G., Elliston, L.A., Hartog, C., Goldstein, D.R., Thu, D., Hollingsworth, Z.R., Collin, F., Synek, B., Holmans, P.A., Young, A.B., Wexler, N.S., Delorenzi, M., Kooperberg, C., Augood, S.J., Faull, R.L, Olson, J.M., Jones, L., Luthi-Carter, R. Regional and cellular gene expression changes in human Huntington's disease brain. Human Molecular Genetics 15(6):965-977, 2006. Full Text

Ince-Dunn, G., Hall, B.J., Hu, S.C., Ripley, B., Huganir, R.L., Olson, J.M., Tapscott, S.J.,Ghosh, A. Regulation of thalamocortical patterning and synaptic maturation by neuroD2. Neuron 49(5):683-695, 2006. Full Text

Spiller, S.E., Ravanpay, A.C., Hahn, A.W., Olson, J.M. Suberoylanilide hydroxamic acid is effective in preclinical studies of medulloblastoma. Journal of Neuro-Oncology 79(3):259-70, 2006. PMID: 16645722. Full Text

Lin, C.-H., Tapscott, S.J., Olson, J.M. Congenital hypothyroidism (cretinism) in neuroD2-deficient mice. Molecular and Cellular Biology 26(11):4311-5, 2006 PMID: 16705180. Full Text

Jones, L., Goldstein, D.R., Hughes, G., Strand, A.D., Collin, F., Dunnett, S.B., Kooperberg, C., Aragaki, A., Olson, J.M., Augood, S.J., Faull, R.L.M., Luthi-Carter, R., Moskvina, V., Hodges, A.K. Assessment of the relationship between pre-chip and post-chip quality measures for Affymetrix GeneChip expression data. BMC Bioinformatics 19(7):211, 2006. Full Text

Fan, W., Khalid, N., Hallahan, A.R., Olson, J.M., Zhao, L.P. A statistical method for predicting splice variants between two groups of samples using GeneChip expression array data. Theor Biol Med Model 3:19, 2006. PMID: 16603076. Full Text

Strand, A.D., Aragaki, A.K., Baquet, Z.C., Hodges, A., Cunningham, P., Holmans, P., Jones, K.R., Jones, L., Kooperberg, C., Olson, J.M. Regional and cellular gene expression changes in human Huntington's disease brain. Human Molecular Genetics 15(6):965-77, 2006. Full Text

Hatton, B.A., Pritchard, J.I., Olson, J.M. Nervous system cancer models: medulloblastoma. Drug Discovery Today: Disease Models 3(2): 167-74, 2006.

Hatton, B.A., Knoepfler. P.S., Kenney, A.M., Rowitch, D.H., de Alborán, I.M., Olson, J.M., Eisenman, R.N. N-myc is an essential downstream effector of Shh signaling during both normal and neoplastic cerebellar growth. Cancer Research 66(17):8655-61, 2006. PMID: 16951180. Full Text

2005

Lin, C.-H., Hansen, S., Wang, Z., Storm, D.R., Tapscott, S.J., Olson, J.M. The dosage of the neuroD2 transcription factor regulates amygdala development and emotional learning. Proceedings of the National Academy of Sciences 102(41): 14877-14882, 2005. PMID: 16203979. Full Text

Veiseh, O., Sun, C., Gunn, J., Kohler, N., Gabikian, P., Lee, D., Bhattarai, N., Ellenbogen, R., Sze, R., Hallahan, A., Olson, J., Zhang, M. An optical and MRI multifunctional nanoprobe for targeting gliomas. Nano Letters 5(6): 1003-1008, 2005. PMID: 15943433. 

Strand, A.D., Aragaki, A.K., Shaw, D., Bird, T., Holton, J., Turner, C., Tapscott, S.J., Tabrizi, S.J., Schapira, A.H., Kooperberg, C., Olson, J.M. Gene expression in Huntington’s disease skeletal muscle: a potential biomarker. Human Molecular Genetics 14(13):1863-1876, 2005. Full Text | Abstract

Kooperberg, C., Aragaki, A., Strand, A.D., Olson, J.M. Significance testing for small microarray experiments. Statistics in Medicine 24:2281-2298, 2005. Full Text

Fan, W., Pritchard, J.I., Olson, J.M., Khalid, N., and Zhao, L.P. A class of models for analyzing GeneChip® gene expression analysis array data. BMC Genomics 6:16, 2005. PMID: 15710039. Full Text | Abstract

Valenza, M., Rigamonti, D., Goffredo, D., Zuccato, C., Fenu, S., Jamot, L., Strand, A., Tarditi, A., Woodman, B., Racchi, M., Mariotti, C., DiDonato, S., Corsini, A., Bates, G., Pruss, R., Olson, J.M., Sipione, S., Tartari, M., Cattaneo, E. Dysfunction of the cholesterol biosynthetic pathway in Huntington's Disease. Journal of Neuroscience 25(43):9932-9939, 2005. Full Text

Benn, C.L., Landles, C., Li, H., Strand, A.D., Woodman, B., Sathasivam, K., Li, S.H., Ghazi-Noori, S., Hockly, E., Faruque, S.M., Cha, J.H., Sharpe, P.T., Olson, J.M., Li, X.J., Bates, G. Contribution of nuclear and extranuclear polyQ to neurological phenotypes in mouse models of Huntington’s disease.Human Molecular Genetics 14(20): 3065-3078, 2005. Full Text

2004

Hallahan, A.R., Pritchard, J.I., Hansen, S., Benson, M., Stoeck, J., Hatton, B.A., Russell, T.L., Bernstein, I.D., Beachy, P.A., Olson, J.M. The SmoA1 mouse model reveals that Notch signaling is critical for the growth and survival of Sonic Hedgehog-induced medulloblastomas. Cancer Research 64:7794-7800, 2004. PMID: 15520185. Full Text | Abstract

Olson, J.M. and Hallahan, A.R. P38 MAP Kinase: a convergence point in cancer therapy. Trends in Molecular Medicine 10(3):125-129, 2004. PMID: 15102355. Full Text | Abstract

Lin, C.H., Stoeck, J., Ravanpay, A.C., Guillemot, F., Tapscott, S.J., and Olson, J.M. Regulation of neuroD2 expression in mouse brain. Developmental Biology 265(1):234-245, 2004. PMID: 14697366. Full Text | Abstract

2003

Hallahan, A.R., Pritchard, J.I., Chandraratna, R.A., Ellenbogen, R., Geyer, J.R., Overland, R.P., Strand, A.D., Tapscott, S.J., and Olson, J.M. BMP- 2 mediates retinoid-induced apoptosis in medulloblastoma cells through a paracrine effect. Nature Medicine 9(8):1033-1038, 2003. PMID: 12872164. Full Text | Abstract

Gilbertson, R.J., Hill, D.A., Hernan, R., Kocak, M., Geyer, R., Olson, J., Gajjar, A, Rush, L., Hamilton, R.L., Finkelstein, S.D., and Pollack, I.F. ERBB1 is amplified and overexpressed in high-grade diffusely infiltrative pediatric brain stem glioma. Clinical Cancer Research 9(10 Pt1): 3620-3624, 2003. Full Text

Ditzler, S., Stoeck, J., LeBlanc, M., Kooperberg, C., Hansen, S., Coppin, L., Olson, J.M. A rapid neurobehavioral assessment reveals that FK506 delays symptom onset in R6/2 Huntington’s disease mice. PreClinica 1(3):115-126, 2003.  Abstract

2002

Berman, D.M., Karhadkar, S.S., Hallahan, A.R., Pritchard, J.I., Eberhart, C.G., Watkins, D.N., Chen, J.K., Cooper, M.K., Taipale, J., Olson, J.M., and Beachy, P.A.Medulloblastoma growth inhibition by hedgehog pathway blockade. Science 297:1559-1561, 2002. PMID: 12202832. Full Text | Abstract

Kooperberg, C., Sipione, S., LeBlanc, M., Strand, A.D., Cattaneo, E., Olson, J.M. Evaluating test statistics to select interesting genes in microarray experiments. Human Molecular Genetics 11(19):2223-2232, 2002. Full Text

Strand, A.D., Olson, J.M., Kooperberg, C. Estimating the statistical significance of gene expression changes observed with oligonucleotide arrays. Human Molecular Genetics 11(19): 2207-2221, 2002. Full Text | Abstract

Xu, X.L., Olson, J.M., Zhao, L.P. A regression based method to identify differentially expressed genes in microarray time course studies and its application in an inducible Huntington’s disease transgenic model. Human Molecular Genetics 11(17):1977-1985, 2002. Full Text | Abstract

Lieberman, A.P., Harmison, G., Strand, A.D., Olson, J.M., Fischbeck, K.H. Altered androgen receptor function due to polyglutamine expansion. Human Molecular Genetics 11(17):1967-1976, 2002.  Abstract

Sipione, S., Rigamonti, D., Valenza, M., Zuccato, C., Conti, L., Pritchard, J., Kooperberg, C., Olson, J.M., Cattaneo, E. Early transcriptional profiles in huntingtin-inducible striatal cells by microarray analyses. Human Molecular Genetics 11(17):1953-1965, 2002. Full Text | PDF | Abstract

Chan, E.Y.W., Luthi-Carter, R., Strand, A., Solano, S.M., Hanson, S.A., DeJohn, M.M., Kooperberg, C., Chase, K.O., DiFiglia, M., Young, A.B., Leavitt, B.R., Cha, J.-H.J., Aronin, N., Hayden, M.R., Olson, J.M. Increased huntingtin protein length reduces the severity of polyglutamine-induced gene expression changes in mouse models of Huntington disease. Human Molecular Genetics 11(17):1939-1951, 2002. Full Text | Abstract

Luthi-Carter, R., Strand, A.D., Hanson, S.A., Kooperberg, C., Schilling, G., LaSpada, A.R., Merry, D.E., Young, A.B., Ross, C.A., Borchelt, D.R., Olson, J.M. Polyglutamine and transcription: gene expression changes shared by DRPLA and Huntington’s disease mouse models reveal context-independent effects. Human Molecular Genetics 11(17):1927-1937, 2002. Full Text | Abstract

Luthi-Carter R., Hanson S.A., Strand A.D., Bergstrom D.A., Chun W., Peters N.L., Woods A.M., Chan E.Y., Kooperberg C., Krainc D., Young A.B., Tapscott S.J., Olson J.M. Dysregulation of gene expression in the R6/2 model of polyglutamine disease: parallel changes in muscle and brain. Hum Mol Genet 11(17): 1911-26, 2002. Full Text | Abstract

Pomeroy S.L., Tamayo P., Gaasenbeek M., Sturla L.M., Angelo M., McLaughlin M.E., Kim J.Y., Goumnerova L.C., Black P.M., Lau C., Allen J.C., Zagzag D., Olson J.M., Curran T., Wetmore C., Biegel J.A., Poggio T., Mukherjee S., Rifkin R., Califano A., Stolovitzky G., Louis D.N., Mesirov J.P., Lander E.S., Golub T.R. Prediction of central nervous system embryonal tumour outcome based on gene expression. Nature 415(6870):436-42, 2002. Full Text | Abstract

Strand, A.D., Olson, J.M., Kooperberg, C. Estimating the statistical significance of gene expression changes observed with oligonucleotide arrays.  Hum Mol Genet. 11(19):2207-21, 2002.  Full Text

2001

Hughes R.E., Lo R.S., Davis C., Strand A.D., Neal C.L., Olson J.M., Fields S. Altered transcription in yeast expressing expanded polyglutamine. Proc. Natl. Acad. Sci. USA. Nov 6;98(23):13201-6, 2001. Full Text | Abstract

Kiehl, T.-K., Olson, J.M., and Pulst, S.-M. The Hereditary Disease Array Group (HDAG) - Microarrays, Models and Mechanisms: A Collaboration Update. Current Genomics 2:221-229, 2001.

J.G., Olson J.M., Tapscott S.J., Zhao L.P.. An efficient and robust statistical modeling approach to discover differentially expressed genes using genomic expression profiles. Genome Res 11(7): 1227-36, 2001. Full Text

Olson J.M., Asakura A., Snider L., Hawkes R., Strand A., Stoeck J., Hallahan A., Pritchard J., Tapscott S.J. NeuroD2 is necessary for development and survival of central nervous system neurons. Dev Biol 234(1): 174-87, 2001. PMID: 11356028. Full Text

Hughes R.E., Olson J.M. Therapeutic opportunities in polyglutamine disease. Nature Med 7(4): 419-23, 2001. Full Text

Johnston, D.L., Benjamin, D.R., and Olson, J.M. Gastrointestinal Stromal Tumor in a Patient with Previous Neuroblastoma. J. Ped. Hem. Oncol. 23:255-256, 2001.

2000

Luthi-Carter R., Strand A., Peters N.L., Solano S.M., Hollingsworth Z.R., Menon A.S., Frey A.S., Spektor B.S., Penney E.B., Schilling G., Ross C.A., Borchelt D.R., Tapscott S.J., Young A.B., Cha J.H., Olson J.M.. Decreased expression of striatal signaling genes in a mouse model of Huntington's disease. Hum Mol Genet 9(9): 1259-71, 2000. Full Text

Farah M.H., Olson J.M., Sucic H.B., Hume R.I., Tapscott S.J., Turner D.L. Generation of neurons by transient expression of neural bHLH proteins in mammalian cells. Development 127(4): 693-702, 2000. Full Text | PDF

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