Brain Tumor Resource Lab

The Brain Tumor Resource Lab strives to generate and distribute patient-derived mouse models and cell lines. Our focus is on pediatric brain tumors.

The figure on the right depicts the best characterized models for model comparison.

Please note that the tissue culture lines should not be implanted into mice and patient derived xenograft cell lines should not be used for tissue culture.

These resources are for academic use only. Please contact us if you are interested in other uses.

Similar to ATCC, the only way to obtain these lines is to place an order through this site. This ensures that we can contact you if important information needs to be conveyed, that you understand that the lines cannot be shared, that a material transfer agreement is in place, and that we can track how these lines are used to benefit science and medicine.

We gratefully acknowledge funding from the National Institutes of Health, Seattle Run of Hope, German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany.

Resources

BTRL Cell Line Detailed Information by Disease or Genetics(xls file)
Models maintained by other institutions

FAQ
Best characterized models of the Brain Tumor Resource Lab
Best characterized models of the Brain Tumor Resource Lab High-res version

BTRL Cell Line Information

Medulloblastoma Lines 

Med-113FH

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Mouse Model: 17p, 9q, Group 3, Medulloblastoma, PTCH1

 

Link to details here: Med-113FH_P1 

 

Med-114FH

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Mouse Model: 17p, Group 3, Medulloblastoma, MYC

Link to details here: Med-114FH_P2
 

Tissue Culture Line: Available 

Med-114FH mCherry/luciferase

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Med-114FH grown in mice then passaged in tissue culture to transduce mCherry/Luciferase

Med-1512FH

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In Mouse Model: Group 4, MYCN

Link to details here: Med-1512FH_P2

Med-1712FH

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In Mouse Model: 9q, PTCH1, SHH

Link to details here: Med-1712FH_P1 

Med-1911FH

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In Mouse Model: 17p, Group 3, MYC

Link to details here: Med-1911FH_P2 

Med-210FH

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In Mouse Models: 17q, 9q, Group 3

Link to details here: Med-210FH_P2 

Med-2112FH

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In Mouse Models:  17p, 17q, 9q, Group 3, MYC

Link to details here: Med-2112FH_P2 

Tissue culture line available 

Med2112FH mCherry/luciferase

+

Med-2112FH grown in mice then passaged in tissue culture to transduce mCherry/Luciferase

 

Med-211FH

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In Mouse Models: GFI1B, Group 3, MYC

Link to details here: Med-211FH_P2 

Med-2312FH

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In Mouse Models: 17p, 17q, 9q, Group 4

Link to details here: Med-2312FH_P2 

Med-314FH

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In Mouse Models:  17p, 17q, 9q, GLI2, MYCN, SHH, TP53

Link to details here: Med-314FH_P2 

Med-314FH mCherry/luciferase

+

Med-314FH grown in mice then passaged in tissue culture to transduce mCherry/Luciferase

Med-411FH

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In Mouse Models: 17p, 17q, Group 3, MYC 

Link to details here: Med-411FH_P2 

Tissue culture line available 

Med-411FH mCherry/Luciferase

+

Med-411FH grown in mice, then quickly passaged in tissue culture to transduce mCherry/Luciferase

Med-610FH

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In Mouse Models: 17q, Group 4, PRDM6

Link to details here: Med-610FH_P2 

Med-615FH

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Has not yet been characterized 

Med-813FH

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In Mouse Models: 17p, 17q, 9q, GLI2, MYCN, SHH, TP53

Link to details here: Med-813FH_P1 

Med-913FH

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In Mouse Models: CTNNB1,WNT

Link to details here: Med-913FH_P1 

PBT-07FH (was Neo-113FH)

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In Mouse Line: 17p, 17q, 9q, Group 3, KBTBD4, Medulloblastoma

Link to details: PBT-07FH_P2
 

High Grade Glioma Lines 

PBT-01FH (was Astro-110FH)

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Mouse Model: EGFR, H3FA/HIST1H3B, High Grade Glioma, K27

Link to details here: PBT-01FH_P2
 

PBT-02FH (was Astro-412FH)

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In Mouse Model: CDK4, FGFR1-4, High Grade Glioma, MDM2, pedRTK1

 

Link to details here: PBT-02FH_P1
 

PBT-03FH (was Astro-413FH)

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In Mouse Model: ATRX, H3FA/HIST1H3B, High Grade Glioma, K27, SETD1A, TP53

 

Link to details here: PBT-03FH_P1
 

PBT-04FH (was Med-311FH)

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In Mouse Model: High Grade Glioma, ID2, MYCN, MYCN

Link to details here: PBT-04FH_P2
 

PBT-05FH (was PNET-109FH)

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In Mouse Model: EGFR, High Grade Glioma, ID2, MGMT Methylation, MYCN, MYCN, PIK3R1

Link to details here: PBT-05FH_P2

In Tissue Culture: EGFR, High Grade Glioma, ID2, MGMT Methylation, MYCN, MYCN, PIK3R1

Link to details here: PBT-05FHTC_P13
 

PBT-05FHTC

+

Tissue culture cell line available.

PBT-06FH (was PNET-212FH)

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In Mouse Model: CDK4, High Grade Glioma, PDGFRA, pedRTK1, TERT, TP53

Link to details here: PBT-06FH_P2
 

GBM-311FH

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In Mouse Models: ATRX, EGFR, FGFR1-4, High Grade Glioma, Hypermutator, MGMT Methylation, MSH2, pedRTK1

Link to details: GBM-311FH_P2
 

GBM-511FHTC

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Tissue Culture: CDKN2A/B, High Grade Glioma, pedRTK1

Link to details here: GBM-511FHTC_P6
 

GBM-611FH

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In Mouse Model: ATRX, EGFR, FGFR1-4, High Grade Glioma, Hypermutator, MSH2, pedRTK1

Link to details here: GBM-611FH_P1
 

GBM-711FH

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High Grade Glioma 

Astro-111FHTC

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Has not been characterized, TC line only

GBM-109FHTC

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Has not been characterized, TC line only 

GBM-110FHTC

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Tissue Culture Line: BRAF, CDKN2A/B, High Grade Glioma, pedRTK2

Link to details here: GBM-110FHTC_P5

Ependymoma Lines 

EPD-210FH

+

In Mouse Model: 1q, Ependymoma, PFA

Link to details here: EPD-210FH_P2
 

Tissue Culture Line: Available

Link to details here: EPD-210FHTC_P3
 

EPD-313FH

+

Both Tissue Culture and PDX cell lines available 

EPD-410FH

+

PDX Cell line available 

EPD-613FH

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In Mouse Model: CDKN2A/B, Ependymoma, RELA, RELA Fusion

 

Link to details here: EPD-613FH_P2
 

EPD-710FH

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In Mouse Model: 1q, Ependymoma, PFA

Link to details here: EPD-710FH_P1
 

Pineoblastoma Cell Lines 

Pineo-113FH

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In Mouse Model: KMT2D, Pineoblastoma

Link to details here: Pineo-113FH_P2
 

PBT-08FH (was Med-313FH)

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Link to details here: PBT-08FH_P2 

Neuroblastoma Cell Lines 

Neuro-211FH Flank

+

Patient Derived Xenograft grown in Flank. 

Atypical Teratoid Rhabdoid Tumor Cell Lines 

ATRT-310FH / ATRT-333FH

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In Mouse Model: SHH, SMARCB1

Link to details here: ATRT-310FH_cP10
 

Tissue Culture Line: Available

Link to details here: ATRT-310FHTC_P4
 

ATRT-311FHTC

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Tissue Culture Line: Atypical Teratoid Rhabdoid Tumor, SHH, SMARCB1

Link to details here: ATRT-311FHTC_P6
 

ATRT-312FH

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In Mouse Model: Atypical Teratoid Rhabdoid Tumor, MYC, SMARCB1

Link to details here: ATRT-312FH_P2