MOENS LAB

Welcome to Moens Lab

The Moens lab studies the early development of the vertebrate brain, using the trans-parent zebrafish embryo as an in vivo model system for neuroepithelial morphogenesis, neuron migration and synapse formation. Our approaches include forward genetic screening for mutants in which these processes fail or occur abnormally and in vivo imaging of normal and mutant embryos, cells and proteins to discover how the genes we identify in our screens control normal brain development. In collaboration with human genetics colleagues at the University of Washington we also use reverse genetics approaches (TILLING and TALENs) to generate mutations in the zebrafish orthologs of genes that cause hindbrain malformations in humans with the goal of using the exquisite in vivo tools available in the zebrafish to understand the developmental basis of these disorders.

For specific projects, see Lab Projects.


Lab Location
Southeast Lake Union Campus
Weintraub Building
Room B2-123 (lab)

Mailing Address
Division of Basic Sciences
Fred Hutchinson Cancer Research Center
1100 Fairview Ave. North
P.O. Box 19024
Mail Stop B2-152
Seattle, WA 98109-1024

Phone
(206) 667-5627 (Cecilia's Office)
(206) 667-5697 (Main Lab)
(206) 667-1590 (Fish Facility)
(206) 667-5432 (Fax)

Administrative Assistant
Karen Brighton
Phone: (206) 667-5707
Room: A1-025
Mail Stop M1-162