John K. Lee received an AB magna cum laude in Biochemical Sciences from Harvard College, an MD from the Geisel School of Medicine at Dartmouth, and a PhD from the Molecular Biology Institute as a Specialty Training and Advanced Research (STAR) fellow at UCLA. His PhD thesis under the mentorship of Dr. Owen Witte focused on characterizing determinants of aggressive prostate cancer. His postdoctoral research with Dr. Witte involved the identification of cell surface antigens in subtypes of prostate cancer and the development of immunotherapeutics against these targets. John started his independent research program at Fred Hutch in March of 2018. He is also a medical oncologist who specializes in metastatic prostate cancer and sees patients at the Seattle Cancer Care Alliance/University of Washington Medical Center.
|ASCI Young Physician-Scientist Award||2020|
|SBUR Eula and Donald S. Coffey Innovative Research Award||2019|
|Movember Foundation-PCF Challenge Award||2019|
|DOD PRCRP Career Development Award||2019|
|DOD PCRP Idea Development Award - New Investigator||2019|
|Safeway Early Career Award in Cancer Research||2019|
|DOD PCRP Physician Research Award||2017|
|STOP CANCER Foundation Grant||2017|
|UCLA CTSI KL2 Translational Science Award||2016|
|PCF Young Investigator Award||2015|
|Tower Cancer Research Foundation Award||2015|
|HHMI-NIH Research Scholar||2004|
Ailin received her B.S. from the Department of Pharmacy, Inner Mongolia Medical University and her Ph.D. from the Department of Pharmacology, Beijing University of Chinese Medicine. Ailin has been involved in various studies investigating the mechanisms of cancer progression and prevention in prostate cancer and leukemia since her postdoctoral training. She has 18 years of experience in cancer biology, specifically focused on the discovery of surrogate biomarkers for early detection and prognostication and the delineation of mechanisms of response and resistance to cancer therapies. Her recent research focuses on clarifying androgen receptor and steroid related mechanisms of resistance in both primary and metastatic prostate cancer. She has been serving as a lead investigator on multiple preclinical studies delineating the mechanisms of resistance to a steroidogenic enzyme CYP17A inhibitor, including induction of AR variants, alterations of steroidogenesis and androgen catabolism, steroid transport, and identification of alternative steroids as novel AR ligands.
Shan received her B.S. and M.S. in Pharmaceutical Science from Wenzhou Medical University and her Ph.D. in Pharmaceutical Science from Oregon State University. Her doctoral thesis focused on identifying key factors that play important roles in skin development, skin inflammatory diseases, and skin carcinogenesis. As a post-doctoral fellow in the Lee Lab, Shan is studying the interactions of oncogenic networks in prostate cancer using a prostate epithelial organoid transformation system. Her ultimate goal is to find new ways to prevent and fight cancer. In her free time, she enjoys hiking, traveling, and baking.
Diana received her B.A. in Biology from Washington Jefferson College and her Ph.D. in Infectious Diseases and Microbiology from the Graduate School of Public Health at the University of Pittsburgh. Her Ph.D. dissertation focused on delineating the role of cellular cholesterol metabolism in HIV-1 intercellular trafficking and disease progression. As a post-doctoral fellow in the Lee Lab, Diana is studying methods to develop T cell therapies against prostate cancer. Her overarching goal is to identify exploitable mechanisms that to increase efficacy of immunotherapies against prostate cancer. In her free time, she enjoys playing volleyball, water sports, reading, and traveling.
Nik received his B.S. in Biological Sciences from Stanford University and his MD at the Keck School of Medicine (USC), graduating with distinction in research for his project focusing on the role of immune cytokines in the regulation of renal salt transporters in mouse models of hypertension. He returned to Stanford to complete his internal medicine residency training. As an oncology fellow in the Lee Lab, Nik is developing strategies to optimize the efficacy and persistence of cellular therapies for metastatic prostate cancer. In his free time, Nik enjoys reading science fiction, indoor horticulture, skiing, and spending time with his family.
Huiyun graduated with a B.S. in Biological Sciences from Nanjing University and a M.S. in Biology with a concentration in Microbial and Cellular Biology from Emporia State University. Her Master's research focused on analyzing gene expression downstream of TP53 under different genetic contexts in malignant melanoma cells. Her current project in the Lee Lab involves developing pipelines to deconvolute diverse population of cells marked by combinations of lentiviral barcodes using next-generation sequencing technologies. She is interested in using computational methods to solve biological problems. In her free time, she enjoys K-pop and J-pop. Huiyun also likes to travel, watch movies, and play with her cat.
Tiffany Pariva - Research Technician, 2018-2020
Medical Student, Loma Linda University School of Medicine
Tanushri Kumar - SURP Student, 2019
Graduate Student, University of Washington Biological Physics, Structure and Design
Nathan Lau - Research Technician, 2018-2019
Medical Student, Zucker School of Medicine at Hofstra/Northwell
Lily Bai - High School Intern, 2018-2019
Undergraduate Student, University of Southern California