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Hsieh Lab News

Oct. 10, 2019

  • Our first collaborative paper with the Paddison Lab (Fred Hutch) hits the press today at Nature Communications! Read here about how m6A marks buttress mRNA specific translation in erythropoiesis. 
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Aug. 1, 2019

  • Congratulations to Yuzhen Liu and Jessie Horn for defining a new druggable interface between androgen receptor signaling and translation initiation, which was recently published in Science Translational Medicine! Read more> Hutch New
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July 31, 2019

  • The Hsieh lab has received funding from Obliteride which was highlighted on NBC's King5 Take 5. 

 

 

 

June 24, 2019

  • Yuzhen and Jessie's AR and translation initiation paper was just accepted. Congratulations! 
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June 18, 2019

  • Congratulations to Brian Winters and Navonil De Sarkar for publishing the first UW/Fred Hutch bladder cancer rapid autopsy genomics paper in JCI Insight! Read more> Hutch News> 
The JCI Team

May 21, 2019

  • Andrew gives a talk at the inaugural AACR Bladder Cancer: Transforming the Field conference in Denver about our work with the UW/Fred Hutch bladder cancer rapid autopsy program. 
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Apr. 1, 2019

  • Congratulations to Yiting who was named an AACR NextGen Star today at the national meeting in Atlanta! Way to go! 
  • Welcome Rowan Hough our new UW undergraduate intern! She will be studying how the translation machinery is usurped in bladder cancer with Sujata.

Mar. 28, 2019

  • While there are very few somatic alterations to the protein components of the translation apparatus, there are a bunch of mutations in the RNA components such as the untranslated regions (UTRs) in cancer.

    

      Check out our new review written by Samantha Schuster that was just published in Trends in Cancer! 

(Click above to read article)

Feb. 27, 2019

  • Congratulations to Sujata who has just been awarded a 2-year DoD PRCRP Horizon Award Fellowship!

Feb. 25, 2019

  • Sujata and Andrew attended the 2019 Translation Machinery in Health and Disease Gordon Research Conference, presented posters, and gave a talk.

            They also took time to get in a picture. Can you find them in the crowd?

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Oct. 31, 2018

  • mRNA specific translation strikes again!

The Hsieh and Paddison labs publish our new findings in bioRxiv on how N6-methyladenosine mRNA marks promote lineage specification in erythrocyte progenitors. Read more >

Oct. 17, 2018

  • Congratulations to Sujata for receiving one of two institutionally funded Interdisciplinary Training Grants as well as the HB Conference Travel Award.

Oct. 1, 2018

  • The Hsieh Lab welcomes our newest MCB graduate student Alex Germanos!

Sept. 12, 2018

  • Hsieh Lab presents our work at the Human Biology Division Retreat held at MOPOP!
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Sept. 7, 2018

  • Andrew gives a talk at the Cold Spring Harbor Translation Control meeting on a new transcriptional-translational interface in cancer.
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Aug. 29, 2018

  • Congratulations to Samantha who was just awarded a 2-year fellowship through the UW Cell & Molecular Biology Training Grant!

July 25, 2018

  • The Hsieh Lab welcomes Alex Germanos an MCB student, who will be rotating into the lab over the summer!

June 5, 2018

  • Welcome to Samantha Schuster, who will join the Hsieh Lab in September 2018 as its very first UW MCB graduate student.

June 1, 2018

  • Welcome to our intrepid interns Lukas Corey (Yale), Rucha Deo (UW), and Sophia Chen (Lakeside HS) who will be plumbing the depths of translation control biology at the bench this summer.

May 12, 2018

  • Hsieh Lab participates in the 2018 BCAN Walk to End Bladder Cancer!
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Apr. 9, 2018

  • tRNA fragment modifications regulate mRNA specific translation and stem cell function. 

Congratulations to our colleague and collaborator Dr. Cristian Bellodi (Lund University) on publishing a paper in Cell this week demonstrating that pseudouridylation of tRNA fragments can control mRNA specific translation and stem cell function. Both Sonali and Yiting had a part in this beautiful work. Congratulations! Read more >

Apr. 3, 2018

  • Rucha was just selected to present her research at the UW 21st Annual Undergraduate Research Symposium. Congratulations!

Mar. 7, 2018

  • Hot off the press! The Hsieh Lab strikes again with another publication.

This one on the results from the Phase II MLN0128  trial in which we teamed up with Drs. Dana Rathkopf (MSKCC) and Tamara Lotan (JHMI) to determine the efficacy of this drug in patients with advanced prostate cancer. We conducted the correlative studies. Hard to believe we first started working with this compound almost a decade ago in cell lines and mice (Hsieh et al. Cancer Cell 2010 and Nature 2012). Read more >


Oct. 26, 2017

  •  Andrew selected to present at UW's Science in Medicine New Investigator Lecture Series.

Oct. 19, 2017

  •  Good News at Fred Hutch!

The Hsieh lab and Dr. Bruce Montgomery were awarded a bladder cancer precision medicine grant from the Seattle Translational Tumor Research program. Read more > 

Oct. 9, 2017

  • Welcome Bill Hardin, another cool addition to the lab! 

Bill hails from the great state of Washington and just finished his PhD in the Department of Biology at UW. He has done some really great work imaging Giardia and molecularly dissecting regulators of cytokinesis with Alex Paredez, which was recently published in PNAS. Welcome aboard!

Oct. 6, 2017

  • Fresh off the press, Sujata’s PUS10 and apoptosis work was just published in Cell Death & Disease.  

Sujata reports that PUS10 nuclear translocation is necessary for TRAIL-mediated apoptosis and cleaved caspase 3 activity amplification. This work was started and primarily done in her PhD mentor’s laboratory (Dr. Ramesh Gupta) and finished in our laboratory. Way to go! Read more >

Oct. 2, 2017

  • Welcome Samantha Schuster, a UW MCB rotation student!

Samantha comes to us from UC Davis where she completed her undergraduate work. She has interned with both Neil Hunter at UC Davis and Dennis Slamon at UCLA and has a keen interest in translational research. She’s also an equestrian!

July 26, 2017

  • Yiting was accepted into the AACR Translational Cancer Research for Basic Scientists Workshop.

Yiting will be networking with instrumental players in the translational cancer field including Drs. George Demetri, Susan Band Horowitz, and Pasi Janne in Boston, MA this fall. Hurray, Yiting!

July 5, 2017

  • Welcome to Brian Winters, a UW Urology Fellow who has just joined the laboratory.

He has a background in translational cancer research with a focus in genitourinary malignancies and a special interest in bladder cancer. In addition, congratulations on getting the 2017 Bladder Cancer Advocacy Network (BCAN) John Quale Travel Fellowship and Young Investigator Awards.  Read more >

June 6, 2017

  • Congratulations to Kalyan who received an ASCO Young Investigator Award! Read more >

June 1, 2017

  • Jessie Horn our intrepid undergrad joins the Hsieh Lab as a technician today! Welcome Jessie, again!

May 2, 2017

  • Congratulations to Lukas who will be attending Yale University this fall!

Mar. 29, 2017

  • Congratulations to Asha! She will be matriculating into the Joint Doctoral program in Cell and Molecular Biology at San Diego State University and the University of California San Diego this fall.

Mar. 17, 2017

  • Hot off the press, the Hsieh Lab participated in a clinical trial of BEZ235 in patients with advanced prostate cancer.  Read more >

Mar. 6, 2017

  • Kalyan, Yiting, and Andrew presented the labs work at the 10th Annual Prostate Cancer Program Retreat in Fort Lauderdale, FL. Hooray for Yiting who won a $500 prize for her poster!
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Jan. 1, 2017

  • This new year the Hsieh Lab is growing! We welcome Sujata Jana and Asha Goodman.

Sujata is a newly minted PhD from the Gupta Lab at Southern Illinois University and will be joining us as a postdoc in March 2017. As a graduate student she studied site specific modifications of tRNA, and the role of an RNA modifying enzyme on cellular homeostasis. Weclome! 

Asha recently graduated from San Diego State University and will be joining our laboratory as a technician. During undergrad she researched in the Deniz Lab at the Scripps Research Institute where she studied protein folding dynamics. 


Dec. 1, 2016

  • Congratulations to Kaylan who was awarded a CCEH Pilot and Feasibility Grant. Way to go!

Oct. 28, 2016

The Hsieh Lab is awarded a 2016 Movember Foundation PCF Challenge Award.

In this grant, the Hsieh Lab will be teaming up with Drs. Brett Carver and Yu Chen from Memorial Sloan Kettering to determine the role of protein synthesis control across of the spectrum of PI3K pathway mutations in prostate cancer. Read more > Also see >

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Oct. 14, 2016

  • Yiting presented her work at the inaugural Human Biology Friday Science Talks alongside Dan Kuppers from the Paddison Lab!

Sept. 7, 2016

  • HB Retreat (Bainbridge, WA)

Postdocs Kalyan and Yiting, who gave oral presentations on their research at the Human Biology Retreat located at Islandwood, enjoy a moment with fellow lab members Yuzhen and Jessie who presented a poster.

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Aug. 16, 2016

  • Kalyan presents his research at the inaugural Oncology T32 Retreat at the Fred Hutch! 

June 3, 2016

  • Fred Hutch/UW Cancer Consortium awards Hsieh Lab pilot research grant.

This grant, based on the work of postdoctoral fellow Li-Jie Wang, technician Yuzhen Liu, and UW undergraduate Jessie Horn, will support the very first preclinical trials testing protein synthesis inhibitors in bladder cancer models. Read more

June 2, 2016

  • Welcome to our very first high school summer intern, Lukas Corey!

Lukas is currently a junior at Interlake High School and will be joining us this summer to work with Yiting. 

May 21, 2016

  • Jessie presents at the 2016 University of Washington Undergraduate Research Symposium.

Congratulations to our very own Jessie Horn who presented her research in an oral presentation at the 19th Annual University of Washington Undergraduate Research Symposium. Great job!

May 2, 2016

  • Kalyan just heard news from the AACR! His application was accepted for the 25th Annual AACR Workshop: Molecular Biology in Clinical Oncology. 

Kalyan will be rubbing shoulders with big players in the field including Drs. Levi Garraway and Charles Sawyers in Snowmass, CO this summer. This will be a great opportunity to make valuable connections with current and future leaders in cancer research. Way to go! 

Apr. 27, 2016

  • The Hsieh Lab is recognized at the 2016 AACR Annual Meeting in New Orleans (and we got some grants too)!

Yiting was awarded the AACR Bristol-Myer Squibb Clinical and Translational Fellowship. Andrew was one of four recipients nationally to receive the inaugural NextGen Grant for Transformative Cancer Research. Go team! Read more >

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Photo by © AACR/Todd Buchanan 2016
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Photo by © AACR/Todd Buchanan 2016

Mar. 10, 2016

  • Andrew earns an ASCI Young Physican-Scientist Award.

He will be presenting research from the lab at the annual AAP/ASCI/APSA Joint Meeting in Chicago next month. Read more >

Feb. 11, 2016

  • Yiting has been awarded a DOD Prostate Cancer Research Program (PCRP) Postdoctoral Training Award!

Congratulations Yiting, great job! She will be co-mentored by Drs. Hsieh and Plymate. Read more >


Nov. 17, 2015

  • Hot off the press: Cell type specific protein synthesis rates mark distinct prostate epithelial cell types for drug resistance.

In collaboration with colleagues at UCSF, utilizing a new genetic model, we demonstrate that aberrant translation initiation is necessary for prostate cancer formation and progression. However, resistance inevitably develops which is remarkably cell type specific. We have discovered that intrinsic protein synthesis rates of distinct prostate epithelial cell types and the levels of the translation inhibitor 4EBP1 are key elements which define sensitivity or resistance to PI3K-AKT-mTOR pathway inhibitors. Our mechanistic studies reveal that these are not only potential biomarkers which can be used in future clinical trials, but are functionally required for the drug resistance phenotype. Read story >

(Click above to read article)

Oct. 20, 2015

  • The Hsieh Lab welcomes Jessie Horn.

Jessie is an undergraduate majoring in biology at the University of Washington. She joins us to conduct preclinical studies targeting the translation apparatus in cancer. Welcome!

Oct. 15, 2015

  • The Hsieh Lab is awarded a grant by the V Foundation for Cancer Research.

Andrew was named a 2015 V Foundation Scholar! The generous support provided by the foundation will be used to study the mechanisms by which aberrant protein synthesis control drives prostate cancer pathogenesis. Read more >

Oct. 1, 2015

  • The Hsieh Lab welcomes Kalyan Banda.

Kalyan is a clinical fellow in the division of Hematology and Oncology at the University of Washington and will be joining us as a postdoc in January 2016. He previously researched with Dr. Ajit Varki at UCSD and has a significant background in glycobiology. Welcome to the team!             

 

  • HB Retreat (Bainbridge Island, WA).

          Postdocs Li-Jie and Yiting present their posters at the Human Biology Retreat.

 

Sept. 8, 2015

  • Stem Cell Center of Lund University (Sweden).

Andrew gives a seminar on protein synthesis control dynamics and cancer etiology at Lund University's Stem Cell Center in Lund, Sweden.

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(Taken at IslandWood, site of 2015 HB Retreat, left to right: Sonali, Yiting, Li-Jie, Yuzhen)

Aug. 28, 2015

  • The Hsieh Lab welcomes Funda Vakar-Lopez, MD.

Funda joins our lab as a pathologist. She is an assistant professor in the Department of Pathology at the University of Washington with a significant background in genitourinary malignancies. Welcome!

Aug. 24, 2015

  • Li-Jie has been awarded a Fred Hutch IDTG Dual Mentor Fellowship!

          Congratulations Li-Jie, way to go! He will be co-mentored by Drs. Hsieh and Henikoff.

Aug. 10, 2015

  •  The Hsieh Lab welcomes Sonali Arora.

Sonali joins our laboratory as our first computational biologist! She was previously a programmer for the R Bioconductor group at the Hutch and comes to our lab with significant bioinformatic experience. Welcome!

June 18, 2015

  • The Hsieh Lab welcomes Yuzhen Liu.

Yuzhen has just earned her bachelor of science in Pharmacology and Toxicology from the University of Toronto. She joins us as our new technician. Welcome to our grand adventure!

June 2, 2015

  • The Hsieh Lab welcomes Prachi Keni.

Prachi Keni, an undergraduate at Northwestern University, joins the lab as our first summer intern. Welcome! 

Apr. 15, 2015

  • The Hsieh Lab wins the inaugural 2015 Fast Pitch competition at the Fred Hutch. 
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Andrew was among 6 new investigators who gave 7-minute fast pitches to a number of generous donors and friends of the Fred Hutch.

Apr. 6, 2015

  • The Hsieh Lab welcomes Yiting Lim from Johns Hopkins.

Yiting earned her PhD studying hematopoietic stem cell biology and the cooperative and druggable nature of Hedgehog and FLT3/ITD signaling in myeloid malignancies. Welcome to the Fred Hutch!

Mar. 11, 2015

  • First rotating graduate student.

          Joseph (Joey) Pangallo, a University of Washington MCB graduate student, will be rotating through the Hsieh Lab for the Spring quarter.

Mar. 3, 2015

  • Good News at Fred Hutch.

New type of biomarker shows promise in predicting prostate cancer recurrence. Dr. Andrew Hsieh, a researcher in the Fred Hutch Human Biology Division, has identified two biomarkers that may improve oncologists’ ability to predict which patients’ prostate cancer will recur after surgery, long before the development of visible cancer elsewhere in the body.  Read more >  

  • First Paper out of Hsieh Lab.

In this paper, we extend our previous findings from the bench (Hsieh et al. Nature 2012) to the bedside (Sheridan et al. Oncotarget 2015). We show for the first time that translationally regulated protein products can be used as biomarkers to predict for future disease aggressiveness in prostate cancer. Read the paper

Feb. 1, 2015

  • The Hsieh Lab welcomes our first postdoctoral researcher, Li-Jie Wang.

Li-Jie is a molecular biologist who earned his PhD interrogating the mechanisms by which AIM2 directs inflammasome formation and cancer etiology. He starts March 1st, welcome to the team! 


Dec. 9, 2014

  • See the motivation behind why we fight.

Andrew is highlighted in a featured researcher piece written by Dr. Sabrina Richards published today at the Hutch.  Read the story >

Nov. 20, 2014

  • Fred Hutch names new president and director.

       Gary Gilliland, MD PhD has just been named the new president and director of the Fred Hutchinson Cancer Research Center. Read more >

Nov. 18, 2014

  • The Hsieh Lab welcomes our first member Ariana Marcassa.

Ariana hails from Canada and will be elucidating the role of aberrant translation control in bladder cancer. She holds a MSc. degree in bacterial genetics from the University of Waterloo and previously studied cytochrome P450 enzymes involved in biosynthesis of the phytohormone gibberellin.

Oct. 8, 2014

  • The Human Biology Division throws a welcome party for the Hsieh Lab.
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Oct. 1, 2014

  • The Hsieh Lab is open.