Check out our new review written by Samantha Schuster that was just published in Trends in Cancer!
They also took time to get in a picture. Can you find them in the crowd?
The Hsieh and Paddison labs publish our new findings in bioRxiv on how N6-methyladenosine mRNA marks promote lineage specification in erythrocyte progenitors. Read more >
Congratulations to our colleague and collaborator Dr. Cristian Bellodi (Lund University) on publishing a paper in Cell this week demonstrating that pseudouridylation of tRNA fragments can control mRNA specific translation and stem cell function. Both Sonali and Yiting had a part in this beautiful work. Congratulations! Read more >
This one on the results from the Phase II MLN0128 trial in which we teamed up with Drs. Dana Rathkopf (MSKCC) and Tamara Lotan (JHMI) to determine the efficacy of this drug in patients with advanced prostate cancer. We conducted the correlative studies. Hard to believe we first started working with this compound almost a decade ago in cell lines and mice (Hsieh et al. Cancer Cell 2010 and Nature 2012). Read more >
The Hsieh lab and Dr. Bruce Montgomery were awarded a bladder cancer precision medicine grant from the Seattle Translational Tumor Research program. Read more >
Bill hails from the great state of Washington and just finished his PhD in the Department of Biology at UW. He has done some really great work imaging Giardia and molecularly dissecting regulators of cytokinesis with Alex Paredez, which was recently published in PNAS. Welcome aboard!
Sujata reports that PUS10 nuclear translocation is necessary for TRAIL-mediated apoptosis and cleaved caspase 3 activity amplification. This work was started and primarily done in her PhD mentor’s laboratory (Dr. Ramesh Gupta) and finished in our laboratory. Way to go! Read more >
Samantha comes to us from UC Davis where she completed her undergraduate work. She has interned with both Neil Hunter at UC Davis and Dennis Slamon at UCLA and has a keen interest in translational research. She’s also an equestrian!
Yiting will be networking with instrumental players in the translational cancer field including Drs. George Demetri, Susan Band Horowitz, and Pasi Janne in Boston, MA this fall. Hurray, Yiting!
He has a background in translational cancer research with a focus in genitourinary malignancies and a special interest in bladder cancer. In addition, congratulations on getting the 2017 Bladder Cancer Advocacy Network (BCAN) John Quale Travel Fellowship and Young Investigator Awards. Read more >
Sujata is a newly minted PhD from the Gupta Lab at Southern Illinois University and will be joining us as a postdoc in March 2017. As a graduate student she studied site specific modifications of tRNA, and the role of an RNA modifying enzyme on cellular homeostasis. Weclome!
Asha recently graduated from San Diego State University and will be joining our laboratory as a technician. During undergrad she researched in the Deniz Lab at the Scripps Research Institute where she studied protein folding dynamics.
The Hsieh Lab is awarded a 2016 Movember Foundation PCF Challenge Award.
In this grant, the Hsieh Lab will be teaming up with Drs. Brett Carver and Yu Chen from Memorial Sloan Kettering to determine the role of protein synthesis control across of the spectrum of PI3K pathway mutations in prostate cancer. Read more > Also see >
Postdocs Kalyan and Yiting, who gave oral presentations on their research at the Human Biology Retreat located at Islandwood, enjoy a moment with fellow lab members Yuzhen and Jessie who presented a poster.
This grant, based on the work of postdoctoral fellow Li-Jie Wang, technician Yuzhen Liu, and UW undergraduate Jessie Horn, will support the very first preclinical trials testing protein synthesis inhibitors in bladder cancer models. Read more >
Lukas is currently a junior at Interlake High School and will be joining us this summer to work with Yiting.
Congratulations to our very own Jessie Horn who presented her research in an oral presentation at the 19th Annual University of Washington Undergraduate Research Symposium. Great job!
Kalyan will be rubbing shoulders with big players in the field including Drs. Levi Garraway and Charles Sawyers in Snowmass, CO this summer. This will be a great opportunity to make valuable connections with current and future leaders in cancer research. Way to go!
Yiting was awarded the AACR Bristol-Myer Squibb Clinical and Translational Fellowship. Andrew was one of four recipients nationally to receive the inaugural NextGen Grant for Transformative Cancer Research. Go team! Read more >
He will be presenting research from the lab at the annual AAP/ASCI/APSA Joint Meeting in Chicago next month. Read more >
Congratulations Yiting, great job! She will be co-mentored by Drs. Hsieh and Plymate. Read more >
In collaboration with colleagues at UCSF, utilizing a new genetic model, we demonstrate that aberrant translation initiation is necessary for prostate cancer formation and progression. However, resistance inevitably develops which is remarkably cell type specific. We have discovered that intrinsic protein synthesis rates of distinct prostate epithelial cell types and the levels of the translation inhibitor 4EBP1 are key elements which define sensitivity or resistance to PI3K-AKT-mTOR pathway inhibitors. Our mechanistic studies reveal that these are not only potential biomarkers which can be used in future clinical trials, but are functionally required for the drug resistance phenotype. Read story >
Jessie is an undergraduate majoring in biology at the University of Washington. She joins us to conduct preclinical studies targeting the translation apparatus in cancer. Welcome!
Andrew was named a 2015 V Foundation Scholar! The generous support provided by the foundation will be used to study the mechanisms by which aberrant protein synthesis control drives prostate cancer pathogenesis. Read more >
Kalyan is a clinical fellow in the division of Hematology and Oncology at the University of Washington and will be joining us as a postdoc in January 2016. He previously researched with Dr. Ajit Varki at UCSD and has a significant background in glycobiology. Welcome to the team!
Postdocs Li-Jie and Yiting present their posters at the Human Biology Retreat.
Andrew gives a seminar on protein synthesis control dynamics and cancer etiology at Lund University's Stem Cell Center in Lund, Sweden.
Funda joins our lab as a pathologist. She is an assistant professor in the Department of Pathology at the University of Washington with a significant background in genitourinary malignancies. Welcome!
Congratulations Li-Jie, way to go! He will be co-mentored by Drs. Hsieh and Henikoff.
Sonali joins our laboratory as our first computational biologist! She was previously a programmer for the R Bioconductor group at the Hutch and comes to our lab with significant bioinformatic experience. Welcome!
Yuzhen has just earned her bachelor of science in Pharmacology and Toxicology from the University of Toronto. She joins us as our new technician. Welcome to our grand adventure!
Prachi Keni, an undergraduate at Northwestern University, joins the lab as our first summer intern. Welcome!
Yiting earned her PhD studying hematopoietic stem cell biology and the cooperative and druggable nature of Hedgehog and FLT3/ITD signaling in myeloid malignancies. Welcome to the Fred Hutch!
Joseph (Joey) Pangallo, a University of Washington MCB graduate student, will be rotating through the Hsieh Lab for the Spring quarter.
New type of biomarker shows promise in predicting prostate cancer recurrence. Dr. Andrew Hsieh, a researcher in the Fred Hutch Human Biology Division, has identified two biomarkers that may improve oncologists’ ability to predict which patients’ prostate cancer will recur after surgery, long before the development of visible cancer elsewhere in the body. Read more >
In this paper, we extend our previous findings from the bench (Hsieh et al. Nature 2012) to the bedside (Sheridan et al. Oncotarget 2015). We show for the first time that translationally regulated protein products can be used as biomarkers to predict for future disease aggressiveness in prostate cancer. Read the paper >
Li-Jie is a molecular biologist who earned his PhD interrogating the mechanisms by which AIM2 directs inflammasome formation and cancer etiology. He starts March 1st, welcome to the team!
Andrew is highlighted in a featured researcher piece written by Dr. Sabrina Richards published today at the Hutch. Read the story >
Ariana hails from Canada and will be elucidating the role of aberrant translation control in bladder cancer. She holds a MSc. degree in bacterial genetics from the University of Waterloo and previously studied cytochrome P450 enzymes involved in biosynthesis of the phytohormone gibberellin.