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Papers from the Gottschling Lab

Thayer NH, Leverich CK, Fitzgibbon MP, Nelson ZW, Henderson KA, Gafken, PR, Hsu JJ, Gottschling DE.
Identification of long-lived proteins retained in cells undergoing repeated asymmetric divisions.
PNAS 2014 111 (39) 14019-14026.
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Henderson KA, Gottschling DE.
Mother-daughter asymmetry of pH underlies aging and rejuvenation in yeast.
eLife 2014;3:e03504.
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Dillin A, Gottschling DE, Nystrom T.
The good and the bad of being connected: the integrons of aging.
Curr Opin Cell Biol. 2014 26:107-12.
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Hughes AL, Gottschling DE.
An early age increase in vacuolar pH limits mitochondrial function and lifespan in yeast.
Nature. 2012 Dec 13;492(7428):261-5.
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Hotz M, Leisner C, Chen D, Manatschal C, Wegleiter T, Ouellet J, Lindstrom D, Gottschling DE, Vogel J, Barral Y.
Spindle pole bodies exploit the mitotic exit network in metaphase to drive their age-dependent segregation.
Cell. 2012 Mar 2;148(5):958-72.
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Dymond JS, Richardson SM, Coombes CE, Babatz T, Muller H, Annaluru N, Blake WJ, Schwerzmann JW, Dai J, Lindstrom DL, Boeke AC, Gottschling DE, Chandrasegaran S, Bader JS, Boeke JD.
Synthetic chromosome arms function in yeast and generate phenotypic diversity by design.
Nature. 2011 Sep 14;477(7365):471-476.
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Lindstrom, D.L., Leverich C.K., Henderson K.A., Gottschling D.E.

Replicative Age Induces Mitotic Recombination in the Ribosomal RNA Gene Cluster of Saccharomyces cerevisiae.
PLoS Genet. 2011 Mar;7(3). e1002015
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Rosenbaum, J.C., Fredrickson E.K., Oeser M.L., Garrett-Engele C.M., Locke M.N., Richardson L.A., Nelson Z.W., Hetrick E.D., Milac T.I., Gottschling D.E., Gardner, R.G.
Disorder targets misorder in nuclear quality control degradation: a disordered ubiquitin ligase directly recognizes its misfolded substrates.
Mol Cell. 2011 Jan 7;41(1):93-106.
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Verzijlbergen, K.F., Menendez-Benito V., van Welsem, T., van Deventer S.J., Lindstrom, D.L., Ovaa H., Neefjes J., Gottschling D.E., van Leeuwen F.
Recombination-induced tag exchange to track old and new proteins.
Proc Natl Acad Sci. 2010 Jan 5;107(1):64-8
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Lindstrom, DL, Gottschling, D.E.
The Mother Enrichment Program: A Genetic System for Facile Replicative Life Span Analysis in Saccharomyces cerevisiae.
Genetics. 2009 Oct;183(2):413-22, 1SI-13SI.
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Dimitrov, L. N., R. B. Brem, L. Kruglyak and D. E. Gottschling.
Polymorphisms in multiple genes contribute to the spontaneous mitochondrial genome instability of S. cerevisiae S288C strains.
Genetics. 2009 Sep;183(1):365-83.
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Veatch, J., McMurray, M.A., Nelson, Z., and D.E. Gottschling.
Mitochondrial Dysfunction Leads to Nuclear Genome Instability via an Iron-Sulfur Cluster Defect.
Cell. 2009 Jun 26;137(7):1247-58.
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Van Welsem, T., Frederiks, F., Verzijlbergen, K. F., Faber, A. W., Nelson, Z. W., Egan, D. A.,Gottschling, D. E., van Leeuwen, F.
Synthetic lethal screens identify gene silencing processes in yeast and implicate the acetylated amino terminus of Sir3 in recognition of the nucleosome core.
Mol Cell Biol. 2008 Jun;28(11):3861-72.
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Andersen, M. P.; Nelson, Z. W.; Hetrick, E. D.; Gottschling, D. E.
A genetic screen for increased loss of heterozygosity in Saccharomyces cerevisiae.
Genetics. 2008 Jul;179(3):1179-95.
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D. E. Gottschling
DNA repair: corrections in the golden years.
Curr Biol. 2006 Nov 21;16(22):R956-8
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R. G. Gardner, Z. W. Nelson & D. E. Gottschling
Ubp10/Dot4p Regulates the Persistence of Ubiquitinated Histone H2B: Distinct Roles in Telomeric Silencing and General Chromatin.
Mol Cell Biol. 2005 Jul;25(14):6123-39
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R. G. Gardner, Z. W. Nelson & D. E. Gottschling
Degradation-mediated protein quality control in the nucleus.
Cell. 120(6):803-15 (2005)
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E. Y. Xu, X. Bi, M. J. Holland, D. E. Gottschling & J. R. Broach
Mutations in the Nucleosome Core Enhance Transcriptional Silencing.
Mol Cell Biol. 25(5):1846-59 (2005)
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D. E. Gottschling
Summary: epigenetics--from phenomenon to field.
Cold Spring Harb Symp Quant Biol. 2004;69:507-19

M. A. McMurray & D. E. Gottschling
Genetic instability in aging yeast: a metastable hyperrecombinational state.
Cold Spring Harb Symp Quant Biol. 2004;69:339-47

M. A. McMurray & D. E. Gottschling
Aging and genetic instability in yeast.
Curr Opin Microbiol 7(6):673-9 (2004)
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A. E. Stellwagen, Z. W. Haimberger, J. R. Veatch & D. E. Gottschling
Ku interacts with telomerase RNA to promote telomere addition at native and broken chromosome ends.
Genes Dev 17(19):2384-2395 (2003)
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M. A. McMurray & D. E. Gottschling
An age-induced switch to a hyper-recombinational state.
Science 301(5641):1908-11 (2003)
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C. M. Smith, P. R. Gafken, Z. Zhang, D. E. Gottschling, J. B. Smith & D. L. Smith
Mass spectrometric quantification of acetylation at specific lysines within the amino-terminal tail of histone H4.
Anal Biochem 316(1):23-33 (2003)
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F. van Leeuwen & D. E. Gottschling
The histone minority report: the variant shall not be silenced.
Cell 112(5):591-3 (2003)
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F. van Leeuwen & D. E. Gottschling
Genome-wide histone modifications: gaining specificity by preventing promiscuity.
Curr Opin Cell Biol 14(6):756-62 (2002)
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C. M. Smith, Z. W. Haimberger, C. O. Johnson, A. J. Wolf, P. R. Gafken, Z. Zhang, M. R. Parthun, & D. E. Gottschling
Heritable chromatin structure: mapping "memory" in histones H3 and H4.
Proc Natl Acad Sci U S A 99 Suppl 4:16454-61 (2002)
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M. L. DuBois, Z. W. Haimberger, M. W. McIntosh, & D. E. Gottschling
A Quantitative Assay for Telomere Protection in Saccharomyces cerevisiae.
Genetics 161:995-1013 (2002)
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F. van Leeuwen & D. E. Gottschling
Assays for gene silencing in yeast.
Methods Enzymol 350:165-86 (2002)

F. van Leeuwen, P. R. Gafken, & D. E. Gottschling

Dot1p modulates silencing in yeast by methylation of the nucleosome core.
Cell 109(6):745-56 (2002)
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A. Bedalov, T. Gatbonton, W. P. Irvine, D. E. Gottschling, & J. A. Simon
Identification of a small molecule inhibitor of Sir2p.
Proc Natl Acad Sci U S A 98(26):15113-15118 (2001)
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S. J. Diede & D. E. Gottschling
Exonuclease activity is required for sequence addition and Cdc13p loading at a de novo telomere.
Current Biology 11(17):1336-40 (2001)
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S. E. Peterson, A. E. Stellwagen, S. J. Diede, M. S. Singer, Z. W. Haimberger, C. O. Johnson, M. Tzoneva, & D. E. Gottschling
The function of a stem-loop in telomerase RNA is linked to the DNA repair protein Ku.
Nature Genetics 27(1): 64-67 (2001)
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D. E. Gottschling
Gene silencing: Two faces of SIR2.
Current Biology 10: R708-R711 (2000)
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M. L. Dubois, S. J. Diede, A. E. Stellwagen, & D. E. Gottschling
All things must end: Telomere dynamics in yeast.
Cold Spring Harbor Symposia on Quantitative Biology 65:281-296 (2000)

T. J. Kelly, S. Qin, D. E. Gottschling, & M. R. Parthun
Type B Histone Acetyltransferase Hat1p Participates in Telomeric Silencing.
Mol Cell Biol 20: 7051-7058 (2000)
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S. J. Diede & D. E. Gottschling
Telomerase-mediated telomere addition in vivo requires DNA primase and DNA polymerases alpha and delta.
Cell 99(7), 723-33 (1999)
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A. Kahana & D. E. Gottschling
DOT4 links silencing and cell growth in Saccharomyces cerevisiae.
Mol Cell Biol 19(10), 6608-6620 (1999)
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D. E. Gottschling & B. Stoddard
Telomeres: structure of a chromosome's aglet.
Current Biology 9(5), R164-7 (1999)
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J. B. Stevenson & D. E. Gottschling
Telomeric chromatin modulates replication timing near chromosome ends.
Genes Dev 13, 146-151 (1999)
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M. S. Singer, A. Kahana, A. J. Wolf, L. L. Meisinger, S. E. Peterson, C. Goggin, M. Mahowald, & D. E. Gottschling
Identification of high-copy disruptors of telomeric silencing in Saccharomyces cerevisiae.
Genetics 150, 613-632, (1998)
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M. R. Parthun, J. Widom & D. E. Gottschling
The major cytoplasmic histone acetyltransferase in yeast: links to chromatin replication and histone metabolism.
Cell 87, 85-94 (1996)
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M. S. Singer & D. E. Gottschling
TLC1: template RNA component of Saccharomyces cerevisiae telomerase [see comments].
Science 266, 404-409 (1994)
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O. M. Aparicio & D. E. Gottschling
Overcoming telomeric silencing: a trans-activator competes to establish gene expression in a cell cycle-dependent way.
Genes Dev 8, 1133-1146 (1994)
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H. Renauld, O. M. Aparicio, P. D. Zierath, B. L. Billington, S. K. Chhablani & D. E. Gottschling
Silent domains are assembled continuously from the telomere and are defined by promoter distance and strength, and by SIR3 dosage.
Genes Dev 7, 1133-45 (1993)
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D. E. Gottschling
Telomere-proximal DNA in Saccharomyces cerevisiae is refractory to methyltransferase activity in vivo.
Proc Natl Acad Sci U S A 89, 4062-5 (1992)
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O. M. Aparicio, B. L. Billington & D. E. Gottschling
Modifiers of position effect are shared between telomeric and silent mating-type loci in S. cerevisiae.
Cell 66, 1279-87 (1991)
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D. E. Gottschling, O. M. Aparicio, B. L. Billington & V. A. Zakian
Position effect at S. cerevisiae telomeres: reversible repression of Pol II transcription.
Cell 63, 751-62 (1990)
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