Housed within the Public Health Sciences Division’s Translational Research Program and directed by Dr. Cyrus Ghajar, the LSM2 seeks to understand some relatively basic questions regarding breast tumor cell dissemination and metastatic relapse. Given that:
a) Tumor cells disseminate from the primary site to distant organs very early during tumor progression, and
b) A substantial fraction of women experience metastatic relapse from breast cancer several years or even decades after initial treatment…
We are interested in uncovering the following:
Answering these questions holds great promise to halt metastatic disease before it ever has a chance to start, which would result in tremendous gains in patient survival. The answers could also hold the key to understanding some general mysteries in cell and developmental biology such as how tissue size is regulated and how tissue homeostasis is maintained.
We have embarked on some exciting projects to answer the above questions, and utilize a number of different models in our pursuit of the answers. We invite you to look around to learn more about what we do, and please get in touch with any questions.