LINDA BUCK LAB -- Publications

Selected Publications

Saraiva LR, Kondoh K, Ye X, Yoon K-h, Hernandez M, Buck LB (2016) Combinatorial effects of odorants on mouse behavior. Proc. Natl. Acad. Sci. USA. 113:E3300-E3306. PMID: 27208093.

Kondoh K, Lu L, Ye X, Olson DP, Lowell BB, Buck LB (2016) A specific area of olfactory cortex involved in stress hormone responses to predator odours. Nature. 532:103-106. PMID: 27001694.

Hanchate NK, Kondoh K, Lu Z, Kuang D, Ye X, Qiu X, Pachter L, Trapnell C, Buck LB (2015) Single-cell transcriptomics reveals receptor transformations during olfactory neurogenesis. Science. 350:1251-1255.  

Yoon K-h, Ragoczy T, Lu Z, Kondoh K, Kuang D, Groudine M, Buck LB (2015) Olfactory receptor genes expressed in distinct lineages are sequestered in different nuclear compartments. Proc. Natl. Acad. Sci. USA., www.pnas.org/cgi/doi/10.1073/pnas. 1506058112.

Horowitz LF, Saraiva LR, Kuang D, Yoon K-h, Buck LB (2014) Olfactory receptor patterning in a higher primate. J. Neurosci. 34:12241-12252.

Ye X, Linton JM, Schork NJ, Buck LB, Petrascheck M (2014) A pharmacological network for lifespan extension in C. elegans. Aging Cell. 13:206-215.

Nara K, Saraiva LR, Ye X, Buck LB (2011) A large-scale analysis of odor coding in the olfactory epithelium. J. Neurosci. 31:9179-9191.

Petrascheck M, Ye X, Buck LB (2009) A high-throughput screen for chemicals that increase the lifespan of Caenorhabditis elegans. Ann N Y Acad Sci. 1170:698-701.

Liberles SD, Horowitz LF, Kuang D, Contos JJ, Wilson KL, Siltberg-Liberles J, Liberles DA, Buck LB (2009) Formyl peptide receptors are candidate chemosensory receptors in the vomeronasal organ. Proc. Natl. Acad. Sci. USA 106:9842-9847.

Petrascheck M, Ye X, and Buck LB (2007) An antidepressant that extends lifespan in adult Caenorhabditis elegans. Nature 450-553-556.

Liberles SD, Buck LB (2006) A second class of chemosensory receptors in the olfactory epithelium. Nature 442:645-650.

Boehm U, Zou Z, Buck LB (Nov 2005) Feedback loops link odor and pheromone signaling with reproduction., Cell, 123 (4), 683-95

Buck LB (Sep 2005) Unraveling the sense of smell (Nobel lecture)., Angewandte Chemie (International ed. in English), 44 (38), 6128-40

Malnic B, Godfrey PA, and Buck LB (2004) The human olfactory receptor gene family. Proc. Natl. Acad. Sci. USA 101:2584-2589.

Godfrey PA, Malnic B, and Buck, LB (2004) The mouse olfactory receptor gene family. Proc. Natl. Acad. Sci. USA 101:2156-2161.

Buck LB (2004) The search for odorant receptors. Cell 116:117-119.

Ranganathan R and Buck LB (2002) Olfactory axon pathfinding: who is the pied piper? Neuron 35:599-600.

Sam M, Vora S, Malnic B, Ma W, Novotny MV and Buck LB (2001) Odorants may arouse instinctive behaviours. Nature 412: 142.

Montmayeur J-P, Liberles SD, Matsunami H and Buck LB (2001) A candidate taste receptor gene near a sweet taste locus. Nature Neurosci. 4:492-498.

Matsunami H, Montmayeur J-P and Buck LB (2000) A family of candidate taste receptors in human and mouse. Nature 404: 601-604.

Buck LB (2000) The molecular architecture of odor and pheromone sensing in mammals. Cell 100: 611-618.

Buck, L. (2000). Smell and taste: the chemical senses. In Principles of Neural Science, E. R. Kandel, J. H. Schwartz, and T. M. Jessell, eds. (New York, McGraw-Hill), pp. 625-652.

Horowitz LF, Montmayeur J, Echelard Y and Buck LB (1999) A genetic approach to trace neural circuits. Proc. Natl. Acad. Sci. USA 96:3194-3199.

Malnic B, Hirono J, Sato T and Buck LB (1999) Combinatorial receptor codes for odors. Cell 96: 713-723.

Matsunami H and Buck LB (1997) A multigene family encoding a diverse array of putative pheromone receptors in mammals. Cell 90: 775-784.

Buck LB (1996) Information coding in the mammalian olfactory system. Cold Spring Harbor Symp. Quant. Biol. 61:147-155.

Berghard A and Buck LB (1996) Sensory transduction in vomeronasal neurons: evidence for Gαo, Gαi2, and adenylyl cyclase II as major components of a pheromone signaling cascade. J. Neurosci. 16:909-918.

Berghard A, Buck LB, and Liman ER (1996) Evidence for distinct signaling mechanisms in two mammalian olfactory sense organs. Proc. Natl. Acad. Sci. USA 93:2365-2369.

Sullivan SL, Adamson MA, Ressler KJ, Kozak CA and Buck LB (1996) The chromosomal distribution of mouse odorant receptor genes. Proc. Natl. Acad. Sci. USA 93:884-888.

Buck LB (1996) Information coding in the vertebrate olfactory system. In: Annu. Rev. of Neurosci. (Cowan WM, Shooter EM, Stevens CF, and Thompson RF, eds.) Palo Alto: Annual Reviews Inc, pp 517-544.

Buck LB (1995) Unraveling Chemosensory Diversity. Cell 83:349-352.

Sullivan SL, Bohm S, Ressler KJ, Horowitz LF and Buck LB (1995) Target-independent pattern specification in the olfactory epithelium. Neuron 15:779-789.

Liman ER and Buck LB (1995) Cloning of odorant receptors. In: Experimental Cell Biology of Taste and Olfaction (Spielman, A and Brand, J, eds.) New York: CRC Press, pp. 425-430.

Sullivan SL, Ressler KJ and Buck LB (1995) Spatial patterning and information coding in the olfactory system. Curr. Opin. Genet. and Dev.: 5:516-523.

Liman ER and Buck LB (1994) A second subunit of the olfactory cyclic nucleotide-gated channel confers high sensitivity to cAMP. Neuron 13:611-621.

Ressler KJ, Sullivan SL, and Buck LB (1994) Information coding in the olfactory system: evidence for a stereotyped and highly organized epitope map in the olfactory bulb. Cell 79:1245-1255.

Ressler KJ, Sullivan SL, and Buck LB (1994) A molecular dissection of spatial patterning in the olfactory system. Curr. Opin. Neurobiol. 4:588-596.

Buck LB, Firestein S, and Margolskee R (1994) Olfaction and taste in vertebrates: molecular and organizational strategies underlying chemosensory perception. In: Basic Neurochemistry (fifth edition). (Siegel GJ, Agranoff BW, Albers RW and Molinoff PB, eds.) New York: Raven Press, pp. 157-177.

Buck LB (1993) Receptor diversity and spatial patterning in the mammalian olfactory system. In: The Molecular Basis of Smell and Taste Transduction. Ciba Found. Sympos. 179. New York: John Wiley and Sons, pp. 51-67.

Buck L (1993) Identification and analysis of a multigene family encoding odorant receptors: implications for mechanisms underlying olfactory information processing. Chem. Senses 18:203-208.

Ressler KJ, Sullivan SL and Buck LB (1993) A zonal organization of odorant receptor gene expression in the olfactory epithelium. Cell 73:597-609.

Ngai J, Dowling MM, Buck L, Axel R and Chess A (1993) The family of genes encoding odorant receptors in the channel catfish. Cell 72:657-666.

Buck LB (1992) The olfactory multigene family. Curr. Opin. Neurobiol. 2:282-288 and Curr. Opin. Genet. and Dev. 2:467-473.

Buck LB (1992) A novel multigene family may encode odorant receptors. In: Sensory Transduction. (Corey DP and Roper SD, eds.) New York: The Rockefeller Press, pp 39-51.

Buck L and Axel R (1991) A novel multigene family may encode odorant receptors: a molecular basis for odor recognition. Cell 65:175-187.

Alevizos A, Karagogeos D, Weiss KR, Buck LB and Koester J (1991) R15 alpha 1 and R15 alpha 2 peptides from Aplysia: comparison of bioactivity, distribution, and function of two peptides generated by alternative splicing. J. Neurobiol. 22:405-417.

Weber DA, Buck LB, Delohery TM, Agostino N and Pernis B (1990) Class II MHC molecules are spontaneously internalized in acidic endosomes by activated B cells. J. Mol. Cell. Immunol. 4:255-268.

Hynes MA, Gitt MA, Barondes SH, Jessell TM and Buck LB (1990) Selective expression of a lactose-binding lectin gene in subsets of central and peripheral neurons. J. Neurosci. 10:1001-1013.

Hynes MA, Buck LB, Gitt M, Barondes S, Dodd J and Jessell TM (1989) Carbohydrate recognition in neuronal development: structure and expression of surface oligosaccharides and beta-galactoside-binding lectins. In: Carbohydrate Recognition in Cellular Function. Ciba Found. Sympos. 145. New York: John Wiley and Sons, pp 189-209.

Weiss KR, Bayley H, Lloyd PE, Tenenbaum R, Gawinowicz-Kolks MA, Buck L, Cropper EC and Kupfermann I (1989) Purification and sequencing of neuropeptides contained in neuron R15 of Aplysia californica. Proc. Natl. Acad. Sci. 86:2913-2917.

Buck LB, Bigelow JM and Axel R (1987) Alternative splicing in individual Aplysia neurons generates neuropeptide diversity. Cell 51:127-133.

Buck LB, Stein R, Palazzolo M, Anderson DJ and Axel R (1983) Gene expression and the diversity of identified neurons. Cold Spring Harbor Symp. Quant. Biol. 48: 485-492.

Roberts JM, Buck LB and Axel R (1983) A structure for amplified DNA. Cell 33:53-63.

Vitetta ES, Cambier JC, Kettman JR, Ligler FS, Yuan D, Buck LB, Zan-Bar I, Strober S, and Uhr J (1980) The role of receptor IgM and IgD in determining triggering and induction of tolerance in murine B cells. In: The Biological Basis of Immunodeficiency. (E.L. Gelfland and H.M. Dosch, eds.) Raven Press, New York, p. 189.

Vitetta E, Pure E, Isakson P, Buck LB and Uhr J (1980) The activation of murine B cells: the role of surface immunoglobulins. Immunol. Rev. 52:211-231.

Buck LB, Yuan D and Vitetta ES (1979) A dichotomy between the expression of IgD on B cells and its requirement for triggering such cells with two T-independent antigens. J. Exp. Med. 149:987-992.