Our goal is to understand the mechanisms that ensure accurate chromosome segregation and thus maintain genomic stability and prevent human disease.
Aneuploidy is the condition where cells contain the wrong number of chromosomes and it is the most common chromosomal abnormality in cancers and the cause of birth defects and other diseases. We therefore study the underlying mechanisms that regulate cell division and chromosome segregation to ensure accurate self-renewal, proliferation and development. We take an interdisciplinary approach that combines biochemical, biophysical, cell biological, genetic and structural approaches using yeast and human cells as model systems. Information about our projects can be found in the research section and information about applying to the lab can found in the join the lab section.